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The Vulnerability Index: A weighted measure of dementia and cognitive impairment risk

INTRODUCTION: A brief, easily calculated and interpretable index to assess vulnerability to developing cognitive impairment is needed in clinical practice and research. To address this, we developed the Vulnerability Index (VI) with the goal of identifying individuals possessing a high risk for cogn...

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Autores principales: Kleiman, Michael J., Galvin, James E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8659607/
https://www.ncbi.nlm.nih.gov/pubmed/34938851
http://dx.doi.org/10.1002/dad2.12249
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author Kleiman, Michael J.
Galvin, James E.
author_facet Kleiman, Michael J.
Galvin, James E.
author_sort Kleiman, Michael J.
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description INTRODUCTION: A brief, easily calculated and interpretable index to assess vulnerability to developing cognitive impairment is needed in clinical practice and research. To address this, we developed the Vulnerability Index (VI) with the goal of identifying individuals possessing a high risk for cognitive impairment. METHODS: Twelve easily obtained sociodemographic, medical, and functional factors were used to develop the VI, with each selectively weighted based on factor analysis and predictive modeling. This cross‐sectional study examined 387 subject‐partner dyads. RESULTS: The VI was found to accurately discriminate between cognitively normal controls and participants with cognitive impairment (area under the curve [AUC]: 0.844; 95% confidence interval [CI]: 0.776‐0.913) and individuals scoring high on the VI (≥8) had worse health, functional, behavioral, cognitive, and quality of life ratings than those with lower scores. DISCUSSION: The VI could be used in screening asymptomatic individuals for risk of cognitive impairment and guiding the development of primary and secondary prevention plans.
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spelling pubmed-86596072021-12-21 The Vulnerability Index: A weighted measure of dementia and cognitive impairment risk Kleiman, Michael J. Galvin, James E. Alzheimers Dement (Amst) Diagnostic Assessment & Prognosis INTRODUCTION: A brief, easily calculated and interpretable index to assess vulnerability to developing cognitive impairment is needed in clinical practice and research. To address this, we developed the Vulnerability Index (VI) with the goal of identifying individuals possessing a high risk for cognitive impairment. METHODS: Twelve easily obtained sociodemographic, medical, and functional factors were used to develop the VI, with each selectively weighted based on factor analysis and predictive modeling. This cross‐sectional study examined 387 subject‐partner dyads. RESULTS: The VI was found to accurately discriminate between cognitively normal controls and participants with cognitive impairment (area under the curve [AUC]: 0.844; 95% confidence interval [CI]: 0.776‐0.913) and individuals scoring high on the VI (≥8) had worse health, functional, behavioral, cognitive, and quality of life ratings than those with lower scores. DISCUSSION: The VI could be used in screening asymptomatic individuals for risk of cognitive impairment and guiding the development of primary and secondary prevention plans. John Wiley and Sons Inc. 2021-12-09 /pmc/articles/PMC8659607/ /pubmed/34938851 http://dx.doi.org/10.1002/dad2.12249 Text en © 2021 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals, LLC on behalf of Alzheimer's Association https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Diagnostic Assessment & Prognosis
Kleiman, Michael J.
Galvin, James E.
The Vulnerability Index: A weighted measure of dementia and cognitive impairment risk
title The Vulnerability Index: A weighted measure of dementia and cognitive impairment risk
title_full The Vulnerability Index: A weighted measure of dementia and cognitive impairment risk
title_fullStr The Vulnerability Index: A weighted measure of dementia and cognitive impairment risk
title_full_unstemmed The Vulnerability Index: A weighted measure of dementia and cognitive impairment risk
title_short The Vulnerability Index: A weighted measure of dementia and cognitive impairment risk
title_sort vulnerability index: a weighted measure of dementia and cognitive impairment risk
topic Diagnostic Assessment & Prognosis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8659607/
https://www.ncbi.nlm.nih.gov/pubmed/34938851
http://dx.doi.org/10.1002/dad2.12249
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