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Wrinkling on Stimuli-Responsive Functional Polymer Surfaces as a Promising Strategy for the Preparation of Effective Antibacterial/Antibiofouling Surfaces

Biocompatible smart interfaces play a crucial role in biomedical or tissue engineering applications, where their ability to actively change their conformation or physico-chemical properties permits finely tuning their surface attributes. Polyelectrolytes, such as acrylic acid, are a particular type...

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Autores principales: González-Henríquez, Carmen M., Rodríguez-Umanzor, Fernando E., Alegría-Gómez, Matías N., Terraza-Inostroza, Claudio A., Martínez-Campos, Enrique, Cue-López, Raquel, Sarabia-Vallejos, Mauricio A., García-Herrera, Claudio, Rodríguez-Hernández, Juan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8659726/
https://www.ncbi.nlm.nih.gov/pubmed/34883766
http://dx.doi.org/10.3390/polym13234262
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author González-Henríquez, Carmen M.
Rodríguez-Umanzor, Fernando E.
Alegría-Gómez, Matías N.
Terraza-Inostroza, Claudio A.
Martínez-Campos, Enrique
Cue-López, Raquel
Sarabia-Vallejos, Mauricio A.
García-Herrera, Claudio
Rodríguez-Hernández, Juan
author_facet González-Henríquez, Carmen M.
Rodríguez-Umanzor, Fernando E.
Alegría-Gómez, Matías N.
Terraza-Inostroza, Claudio A.
Martínez-Campos, Enrique
Cue-López, Raquel
Sarabia-Vallejos, Mauricio A.
García-Herrera, Claudio
Rodríguez-Hernández, Juan
author_sort González-Henríquez, Carmen M.
collection PubMed
description Biocompatible smart interfaces play a crucial role in biomedical or tissue engineering applications, where their ability to actively change their conformation or physico-chemical properties permits finely tuning their surface attributes. Polyelectrolytes, such as acrylic acid, are a particular type of smart polymers that present pH responsiveness. This work aims to fabricate stable hydrogel films with reversible pH responsiveness that could spontaneously form wrinkled surface patterns. For this purpose, the photosensitive reaction mixtures were deposited via spin-coating over functionalized glasses. Following vacuum, UV, or either plasma treatments, it is possible to spontaneously form wrinkles, which could increase cell adherence. The pH responsiveness of the material was evaluated, observing an abrupt variation in the film thickness as a function of the environmental pH. Moreover, the presence of the carboxylic acid functional groups at the interface was evidenced by analyzing the adsorption/desorption capacity using methylene blue as a cationic dye model. The results demonstrated that increasing the acrylic acid in the microwrinkled hydrogel effectively improved the adsorption and release capacity and the ability of the carboxylic groups to establish ionic interactions with methylene blue. Finally, the role of the acrylic acid groups and the surface topography (smooth or wrinkled) on the final antibacterial properties were investigated, demonstrating their efficacy against both gram-positive and gram-negative bacteria model strains (E. coli and S. Aureus). According to our findings, microwrinkled hydrogels presented excellent antibacterial properties improving the results obtained for planar (smooth) hydrogels.
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spelling pubmed-86597262021-12-10 Wrinkling on Stimuli-Responsive Functional Polymer Surfaces as a Promising Strategy for the Preparation of Effective Antibacterial/Antibiofouling Surfaces González-Henríquez, Carmen M. Rodríguez-Umanzor, Fernando E. Alegría-Gómez, Matías N. Terraza-Inostroza, Claudio A. Martínez-Campos, Enrique Cue-López, Raquel Sarabia-Vallejos, Mauricio A. García-Herrera, Claudio Rodríguez-Hernández, Juan Polymers (Basel) Article Biocompatible smart interfaces play a crucial role in biomedical or tissue engineering applications, where their ability to actively change their conformation or physico-chemical properties permits finely tuning their surface attributes. Polyelectrolytes, such as acrylic acid, are a particular type of smart polymers that present pH responsiveness. This work aims to fabricate stable hydrogel films with reversible pH responsiveness that could spontaneously form wrinkled surface patterns. For this purpose, the photosensitive reaction mixtures were deposited via spin-coating over functionalized glasses. Following vacuum, UV, or either plasma treatments, it is possible to spontaneously form wrinkles, which could increase cell adherence. The pH responsiveness of the material was evaluated, observing an abrupt variation in the film thickness as a function of the environmental pH. Moreover, the presence of the carboxylic acid functional groups at the interface was evidenced by analyzing the adsorption/desorption capacity using methylene blue as a cationic dye model. The results demonstrated that increasing the acrylic acid in the microwrinkled hydrogel effectively improved the adsorption and release capacity and the ability of the carboxylic groups to establish ionic interactions with methylene blue. Finally, the role of the acrylic acid groups and the surface topography (smooth or wrinkled) on the final antibacterial properties were investigated, demonstrating their efficacy against both gram-positive and gram-negative bacteria model strains (E. coli and S. Aureus). According to our findings, microwrinkled hydrogels presented excellent antibacterial properties improving the results obtained for planar (smooth) hydrogels. MDPI 2021-12-06 /pmc/articles/PMC8659726/ /pubmed/34883766 http://dx.doi.org/10.3390/polym13234262 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
González-Henríquez, Carmen M.
Rodríguez-Umanzor, Fernando E.
Alegría-Gómez, Matías N.
Terraza-Inostroza, Claudio A.
Martínez-Campos, Enrique
Cue-López, Raquel
Sarabia-Vallejos, Mauricio A.
García-Herrera, Claudio
Rodríguez-Hernández, Juan
Wrinkling on Stimuli-Responsive Functional Polymer Surfaces as a Promising Strategy for the Preparation of Effective Antibacterial/Antibiofouling Surfaces
title Wrinkling on Stimuli-Responsive Functional Polymer Surfaces as a Promising Strategy for the Preparation of Effective Antibacterial/Antibiofouling Surfaces
title_full Wrinkling on Stimuli-Responsive Functional Polymer Surfaces as a Promising Strategy for the Preparation of Effective Antibacterial/Antibiofouling Surfaces
title_fullStr Wrinkling on Stimuli-Responsive Functional Polymer Surfaces as a Promising Strategy for the Preparation of Effective Antibacterial/Antibiofouling Surfaces
title_full_unstemmed Wrinkling on Stimuli-Responsive Functional Polymer Surfaces as a Promising Strategy for the Preparation of Effective Antibacterial/Antibiofouling Surfaces
title_short Wrinkling on Stimuli-Responsive Functional Polymer Surfaces as a Promising Strategy for the Preparation of Effective Antibacterial/Antibiofouling Surfaces
title_sort wrinkling on stimuli-responsive functional polymer surfaces as a promising strategy for the preparation of effective antibacterial/antibiofouling surfaces
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8659726/
https://www.ncbi.nlm.nih.gov/pubmed/34883766
http://dx.doi.org/10.3390/polym13234262
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