Cutaneous Type 2 Innate Lymphoid Cells Come in Distinct Flavors

In a new article published in JID Innovations, Nakatani-Kusakabe et al. (2021) show that type 2 innate lymphoid cells (ILC2s) in the skin of mice with IL-33 overexpression in keratinocytes are heterogeneous and consist of two distinct populations: skin-resident ILC2s and circulating ILC2s. They show...

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Detalles Bibliográficos
Autores principales: Leyva-Castillo, Juan-Manuel, Geha, Raif S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8659736/
https://www.ncbi.nlm.nih.gov/pubmed/34909740
http://dx.doi.org/10.1016/j.xjidi.2021.100059
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author Leyva-Castillo, Juan-Manuel
Geha, Raif S.
author_facet Leyva-Castillo, Juan-Manuel
Geha, Raif S.
author_sort Leyva-Castillo, Juan-Manuel
collection PubMed
description In a new article published in JID Innovations, Nakatani-Kusakabe et al. (2021) show that type 2 innate lymphoid cells (ILC2s) in the skin of mice with IL-33 overexpression in keratinocytes are heterogeneous and consist of two distinct populations: skin-resident ILC2s and circulating ILC2s. They show that the circulating subset of skin ILC2s migrates to draining lymph nodes during hapten-induced cutaneous inflammation to potentially enhance the adaptive immune response.
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spelling pubmed-86597362021-12-13 Cutaneous Type 2 Innate Lymphoid Cells Come in Distinct Flavors Leyva-Castillo, Juan-Manuel Geha, Raif S. JID Innov Commentary In a new article published in JID Innovations, Nakatani-Kusakabe et al. (2021) show that type 2 innate lymphoid cells (ILC2s) in the skin of mice with IL-33 overexpression in keratinocytes are heterogeneous and consist of two distinct populations: skin-resident ILC2s and circulating ILC2s. They show that the circulating subset of skin ILC2s migrates to draining lymph nodes during hapten-induced cutaneous inflammation to potentially enhance the adaptive immune response. Elsevier 2021-09-23 /pmc/articles/PMC8659736/ /pubmed/34909740 http://dx.doi.org/10.1016/j.xjidi.2021.100059 Text en © 2021 The Authors. Published by Elsevier, Inc. on behalf of the Society for Investigative Dermatology. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Commentary
Leyva-Castillo, Juan-Manuel
Geha, Raif S.
Cutaneous Type 2 Innate Lymphoid Cells Come in Distinct Flavors
title Cutaneous Type 2 Innate Lymphoid Cells Come in Distinct Flavors
title_full Cutaneous Type 2 Innate Lymphoid Cells Come in Distinct Flavors
title_fullStr Cutaneous Type 2 Innate Lymphoid Cells Come in Distinct Flavors
title_full_unstemmed Cutaneous Type 2 Innate Lymphoid Cells Come in Distinct Flavors
title_short Cutaneous Type 2 Innate Lymphoid Cells Come in Distinct Flavors
title_sort cutaneous type 2 innate lymphoid cells come in distinct flavors
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8659736/
https://www.ncbi.nlm.nih.gov/pubmed/34909740
http://dx.doi.org/10.1016/j.xjidi.2021.100059
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