TNF-α and IL-1β Do Not Induce Langerhans Cell Migration by Inhibiting TGFβ Activation

In the skin, Langerhans cells (LCs) require autocrine latent TGFβ that is transactivated by the integrins ανβ6 and ανβ8 expressed by keratinocytes (KCs) for long-term epidermal retention. Selective expression of a ligand-independent, constitutively active form of TGFβR1 inhibits LC migration during...

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Detalles Bibliográficos
Autores principales: De La Cruz Diaz, Jacinto S., Hirai, Toshiro, Anh-Thu Nguyen, Breanna, Zenke, Yukari, Yang, Yi, Li, Haiyue, Nishimura, Stephen, Kaplan, Daniel H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8659779/
https://www.ncbi.nlm.nih.gov/pubmed/34909727
http://dx.doi.org/10.1016/j.xjidi.2021.100028

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8659779/
https://www.ncbi.nlm.nih.gov/pubmed/34909727
http://dx.doi.org/10.1016/j.xjidi.2021.100028

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