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Exploring the binding of rationally engineered tandem-repeat proteins to E3 ubiquitin ligase Keap1
The process of displaying functional peptides by ‘grafting’ them onto loops of a stable protein scaffold can be used to impart binding affinity for a target, but it can be difficult to predict the affinity of the grafted peptide and the effect of grafting on scaffold stability. In this study, we sho...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Oxford University Press
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8660007/ https://www.ncbi.nlm.nih.gov/pubmed/34882773 http://dx.doi.org/10.1093/protein/gzab027 |