Glial Nrf2 signaling mediates the neuroprotection exerted by Gastrodia elata Blume in Lrrk2-G2019S Parkinson’s disease

The most frequent missense mutations in familial Parkinson’s disease (PD) occur in the highly conserved LRRK2/PARK8 gene with G2019S mutation. We previously established a fly model of PD carrying the LRRK2-G2019S mutation that exhibited the parkinsonism-like phenotypes. An herbal medicine, Gastrodia...

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Detalles Bibliográficos
Autores principales: Lin, Yu-En, Lin, Chin-Hsien, Ho, En-Peng, Ke, Yi-Ci, Petridi, Stavroula, Elliott, Christopher JH, Sheen, Lee-Yan, Chien, Cheng-Ting
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8660019/
https://www.ncbi.nlm.nih.gov/pubmed/34779396
http://dx.doi.org/10.7554/eLife.73753

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8660019/
https://www.ncbi.nlm.nih.gov/pubmed/34779396
http://dx.doi.org/10.7554/eLife.73753

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