HLA-A(∗)02:01 restricted T cell receptors against the highly conserved SARS-CoV-2 polymerase cross-react with human coronaviruses

Cross-reactivity and direct killing of target cells remain underexplored for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)-specific CD8(+) T cells. Isolation of T cell receptors (TCRs) and overexpression in allogeneic cells allows for extensive T cell reactivity profiling. We identify...

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Detalles Bibliográficos
Autores principales: Nesterenko, Pavlo A., McLaughlin, Jami, Tsai, Brandon L., Burton Sojo, Giselle, Cheng, Donghui, Zhao, Daniel, Mao, Zhiyuan, Bangayan, Nathanael J., Obusan, Matthew B., Su, Yapeng, Ng, Rachel H., Chour, William, Xie, Jingyi, Li, Yan-Ruide, Lee, Derek, Noguchi, Miyako, Carmona, Camille, Phillips, John W., Kim, Jocelyn T., Yang, Lili, Heath, James R., Boutros, Paul C., Witte, Owen N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Author(s). 2021
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8660260/
https://www.ncbi.nlm.nih.gov/pubmed/34919800
http://dx.doi.org/10.1016/j.celrep.2021.110167

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