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Podocyte Bioenergetics in the Development of Diabetic Nephropathy: The Role of Mitochondria
Diabetic nephropathy (DN) is the leading cause of kidney failure, with an increasing incidence worldwide. Mitochondrial dysfunction is known to occur in DN and has been implicated in the underlying pathogenesis of disease. These complex organelles have an array of important cellular functions and in...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Oxford University Press
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8660556/ https://www.ncbi.nlm.nih.gov/pubmed/34791124 http://dx.doi.org/10.1210/endocr/bqab234 |
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author | Audzeyenka, Irena Bierżyńska, Agnieszka Lay, Abigail C |
author_facet | Audzeyenka, Irena Bierżyńska, Agnieszka Lay, Abigail C |
author_sort | Audzeyenka, Irena |
collection | PubMed |
description | Diabetic nephropathy (DN) is the leading cause of kidney failure, with an increasing incidence worldwide. Mitochondrial dysfunction is known to occur in DN and has been implicated in the underlying pathogenesis of disease. These complex organelles have an array of important cellular functions and involvement in signaling pathways, and understanding the intricacies of these responses in health, as well as how they are damaged in disease, is likely to highlight novel therapeutic avenues. A key cell type damaged early in DN is the podocyte, and increasing studies have focused on investigating the role of mitochondria in podocyte injury. This review will summarize what is known about podocyte mitochondrial dynamics in DN, with a particular focus on bioenergetic pathways, highlighting key studies in this field and potential opportunities to target, enhance or protect podocyte mitochondrial function in the treatment of DN. |
format | Online Article Text |
id | pubmed-8660556 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-86605562021-12-13 Podocyte Bioenergetics in the Development of Diabetic Nephropathy: The Role of Mitochondria Audzeyenka, Irena Bierżyńska, Agnieszka Lay, Abigail C Endocrinology Mini-Review Diabetic nephropathy (DN) is the leading cause of kidney failure, with an increasing incidence worldwide. Mitochondrial dysfunction is known to occur in DN and has been implicated in the underlying pathogenesis of disease. These complex organelles have an array of important cellular functions and involvement in signaling pathways, and understanding the intricacies of these responses in health, as well as how they are damaged in disease, is likely to highlight novel therapeutic avenues. A key cell type damaged early in DN is the podocyte, and increasing studies have focused on investigating the role of mitochondria in podocyte injury. This review will summarize what is known about podocyte mitochondrial dynamics in DN, with a particular focus on bioenergetic pathways, highlighting key studies in this field and potential opportunities to target, enhance or protect podocyte mitochondrial function in the treatment of DN. Oxford University Press 2021-11-16 /pmc/articles/PMC8660556/ /pubmed/34791124 http://dx.doi.org/10.1210/endocr/bqab234 Text en © The Author(s) 2021. Published by Oxford University Press on behalf of the Endocrine Society. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Mini-Review Audzeyenka, Irena Bierżyńska, Agnieszka Lay, Abigail C Podocyte Bioenergetics in the Development of Diabetic Nephropathy: The Role of Mitochondria |
title | Podocyte Bioenergetics in the Development of Diabetic Nephropathy: The Role of Mitochondria |
title_full | Podocyte Bioenergetics in the Development of Diabetic Nephropathy: The Role of Mitochondria |
title_fullStr | Podocyte Bioenergetics in the Development of Diabetic Nephropathy: The Role of Mitochondria |
title_full_unstemmed | Podocyte Bioenergetics in the Development of Diabetic Nephropathy: The Role of Mitochondria |
title_short | Podocyte Bioenergetics in the Development of Diabetic Nephropathy: The Role of Mitochondria |
title_sort | podocyte bioenergetics in the development of diabetic nephropathy: the role of mitochondria |
topic | Mini-Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8660556/ https://www.ncbi.nlm.nih.gov/pubmed/34791124 http://dx.doi.org/10.1210/endocr/bqab234 |
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