Cryo-EM structures of human RNA polymerase I

RNA polymerase I (Pol I) specifically synthesizes ribosomal RNA. Pol I upregulation is linked to cancer, while mutations in the Pol I machinery lead to developmental disorders. Here we report the cryo-EM structure of elongating human Pol I at 2.7 Å resolution. In the exit tunnel, we observe a double...

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Detalles Bibliográficos
Autores principales: Misiaszek, Agata D., Girbig, Mathias, Grötsch, Helga, Baudin, Florence, Murciano, Brice, Lafita, Aleix, Müller, Christoph W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8660638/
https://www.ncbi.nlm.nih.gov/pubmed/34887565
http://dx.doi.org/10.1038/s41594-021-00693-4

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