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Risk Factors for Progression in Vestibular Schwannomas After Incomplete Resection: A Single Center Retrospective Study

Background and Purpose: The risk factors for progression in vestibular schwannomas (VSs) after incomplete resection (IR) remain to be elucidated. The purpose of this study was to investigate the risk factors for progression in remnant VSs after surgery. Methods: From January 2009 to January 2018, 14...

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Autores principales: Li, Jiuhong, Deng, Xueyun, Ke, Daibo, Cheng, Jian, Zhang, Si, Hui, Xuhui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8660677/
https://www.ncbi.nlm.nih.gov/pubmed/34899585
http://dx.doi.org/10.3389/fneur.2021.778590
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author Li, Jiuhong
Deng, Xueyun
Ke, Daibo
Cheng, Jian
Zhang, Si
Hui, Xuhui
author_facet Li, Jiuhong
Deng, Xueyun
Ke, Daibo
Cheng, Jian
Zhang, Si
Hui, Xuhui
author_sort Li, Jiuhong
collection PubMed
description Background and Purpose: The risk factors for progression in vestibular schwannomas (VSs) after incomplete resection (IR) remain to be elucidated. The purpose of this study was to investigate the risk factors for progression in remnant VSs after surgery. Methods: From January 2009 to January 2018, 140 consecutive patients who underwent IR of VSs via suboccipital retrosigmoid approach in our institution were retrospectively analyzed. During follow-up, if progression was detected, the patient was classified into Progressive Group (PG); if the residual tumor was stable or shrank, the patient was classified into Stable Group (SG). Univariate analysis and multivariate analysis were used to evaluate the risk factors for progression after IR of VSs. Results: After a mean follow-up of 80.4 months (range, 24–134 months), 35 (25.0%) patients (PG) had a progression, and no progression was detected in 105 (75.0%) patients (SG). The average tumor size was 36.5 ± 8.9 mm in PG and 31.0 ± 9.8 mm in SG, respectively. The residual tumor volume was 304.6 ± 443.3 mm(3) in PG and 75.9 ± 60.0 mm(3) in SG, respectively. Univariate analysis showed that preoperative tumor size, residual tumor volume, and irregular internal auditory canal (IAC) expansion were significantly different between the two groups, whereas gender, age, cystic component, or Ki-67 labeling index (LI) did not differ significantly between the two groups. Multivariate analysis showed residual tumor volume was the independent risk factor for progression. Conclusions: VSs that underwent IR with larger preoperative size, greater residual tumor volume, or irregular IAC expansion may have a higher progression rate. Strict follow-up with shorter interval in these patients to detect early progression is necessary.
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spelling pubmed-86606772021-12-11 Risk Factors for Progression in Vestibular Schwannomas After Incomplete Resection: A Single Center Retrospective Study Li, Jiuhong Deng, Xueyun Ke, Daibo Cheng, Jian Zhang, Si Hui, Xuhui Front Neurol Neurology Background and Purpose: The risk factors for progression in vestibular schwannomas (VSs) after incomplete resection (IR) remain to be elucidated. The purpose of this study was to investigate the risk factors for progression in remnant VSs after surgery. Methods: From January 2009 to January 2018, 140 consecutive patients who underwent IR of VSs via suboccipital retrosigmoid approach in our institution were retrospectively analyzed. During follow-up, if progression was detected, the patient was classified into Progressive Group (PG); if the residual tumor was stable or shrank, the patient was classified into Stable Group (SG). Univariate analysis and multivariate analysis were used to evaluate the risk factors for progression after IR of VSs. Results: After a mean follow-up of 80.4 months (range, 24–134 months), 35 (25.0%) patients (PG) had a progression, and no progression was detected in 105 (75.0%) patients (SG). The average tumor size was 36.5 ± 8.9 mm in PG and 31.0 ± 9.8 mm in SG, respectively. The residual tumor volume was 304.6 ± 443.3 mm(3) in PG and 75.9 ± 60.0 mm(3) in SG, respectively. Univariate analysis showed that preoperative tumor size, residual tumor volume, and irregular internal auditory canal (IAC) expansion were significantly different between the two groups, whereas gender, age, cystic component, or Ki-67 labeling index (LI) did not differ significantly between the two groups. Multivariate analysis showed residual tumor volume was the independent risk factor for progression. Conclusions: VSs that underwent IR with larger preoperative size, greater residual tumor volume, or irregular IAC expansion may have a higher progression rate. Strict follow-up with shorter interval in these patients to detect early progression is necessary. Frontiers Media S.A. 2021-11-26 /pmc/articles/PMC8660677/ /pubmed/34899585 http://dx.doi.org/10.3389/fneur.2021.778590 Text en Copyright © 2021 Li, Deng, Ke, Cheng, Zhang and Hui. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Li, Jiuhong
Deng, Xueyun
Ke, Daibo
Cheng, Jian
Zhang, Si
Hui, Xuhui
Risk Factors for Progression in Vestibular Schwannomas After Incomplete Resection: A Single Center Retrospective Study
title Risk Factors for Progression in Vestibular Schwannomas After Incomplete Resection: A Single Center Retrospective Study
title_full Risk Factors for Progression in Vestibular Schwannomas After Incomplete Resection: A Single Center Retrospective Study
title_fullStr Risk Factors for Progression in Vestibular Schwannomas After Incomplete Resection: A Single Center Retrospective Study
title_full_unstemmed Risk Factors for Progression in Vestibular Schwannomas After Incomplete Resection: A Single Center Retrospective Study
title_short Risk Factors for Progression in Vestibular Schwannomas After Incomplete Resection: A Single Center Retrospective Study
title_sort risk factors for progression in vestibular schwannomas after incomplete resection: a single center retrospective study
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8660677/
https://www.ncbi.nlm.nih.gov/pubmed/34899585
http://dx.doi.org/10.3389/fneur.2021.778590
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