Cargando…

Diabetes status modifies the long-term effect of lipoprotein-associated phospholipase A2 on major coronary events

AIMS/HYPOTHESIS: Lipoprotein-associated phospholipase A2 (Lp-PLA2) activity has an independent prognostic association with major coronary events (MCE). However, no study has investigated whether type 2 diabetes status modifies the effect of Lp-PLA2 activity or inhibition on the risk of MCE. We inves...

Descripción completa

Detalles Bibliográficos
Autores principales:	Siddiqui, Moneeza K., Smith, Gillian, St Jean, Pamela, Dawed, Adem Y., Bell, Samira, Soto-Pedre, Enrique, Kennedy, Gwen, Carr, Fiona, Wallentin, Lars, White, Harvey, Macphee, Colin H., Waterworth, Dawn, Palmer, Colin N. A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8660745/ https://www.ncbi.nlm.nih.gov/pubmed/34562103 http://dx.doi.org/10.1007/s00125-021-05574-5

Ejemplares similares

Polymorphism in INSR Locus Modifies Risk of Atrial Fibrillation in Patients on Thyroid Hormone Replacement Therapy
por: Soto-Pedre, Enrique, et al.
Publicado: (2021)

Identification of 4 New Loci Associated With Primary Hyperparathyroidism (PHPT) and a Polygenic Risk Score for PHPT
por: Soto-Pedre, Enrique, et al.
Publicado: (2022)

The Genetics of Adverse Drug Outcomes in Type 2 Diabetes: A Systematic Review
por: Baye, Assefa M., et al.
Publicado: (2021)

Weight variability and cardiovascular outcomes: a systematic review and meta-analysis
por: Massey, Robert J., et al.
Publicado: (2023)

Characteristics and outcomes of health and social care workers testing positive for SARS-CoV-2 in the Tayside region of Scotland
por: Siddiqui, Moneeza K., et al.
Publicado: (2020)

Common Statin Intolerance Variants in ABCB1 and LILRB5 Show Synergistic Effects on Statin Response: An Observational Study Using Electronic Health Records
por: Melhem, Alaa’ Lutfi, et al.
Publicado: (2021)

A gene risk score using missense variants in SLCO1B1 is associated with earlier onset statin intolerance
por: Bigossi, Margherita, et al.
Publicado: (2023)

The effect of lipoprotein-associated phospholipase A(2) deficiency on pulmonary allergic responses in aspergillus fumigatus sensitized mice
por: Jiang, Zhilong, et al.
Publicado: (2012)

Lp-PLA(2) activity is associated with increased risk of diabetic retinopathy: a longitudinal disease progression study
por: Siddiqui, Moneeza K., et al.
Publicado: (2018)

Effect of Darapladib Treatment on Endarterectomy Carotid Plaque Lipoprotein-Associated Phospholipase A(2) Activity: A Randomized, Controlled Trial
por: Johnson, Joel L., et al.
Publicado: (2014)

Young-onset diabetes in Asian Indians is associated with lower measured and genetically determined beta cell function
por: Siddiqui, Moneeza K., et al.
Publicado: (2022)

Correction to: Young-onset diabetes in Asian Indians is associated with lower measured and genetically determined beta cell function
por: Siddiqui, Moneeza K., et al.
Publicado: (2022)

The association between SARS-CoV-2 RT-PCR cycle threshold and mortality in a community cohort
por: Waudby-West, Rupert, et al.
Publicado: (2021)

Atherosclerotic Plaque Inflammation Varies Between Vascular Sites and Correlates With Response to Inhibition of Lipoprotein‐Associated Phospholipase A(2)
por: Fenning, Robert S., et al.
Publicado: (2015)

Platelet Aggregation Unchanged by Lipoprotein-Associated Phospholipase A(2) Inhibition: Results from an In Vitro Study and Two Randomized Phase I Trials
por: Shaddinger, Bonnie C., et al.
Publicado: (2014)

Lipoprotein-Associated Phospholipase A(2) Loss-of-Function Variant and Risk of Vascular Diseases in 90,000 Chinese Adults
por: Millwood, Iona Y., et al.
Publicado: (2016)

Pharmacogenetic meta-analysis of baseline risk factors, pharmacodynamic, efficacy and tolerability endpoints from two large global cardiovascular outcomes trials for darapladib
por: Yeo, Astrid, et al.
Publicado: (2017)

The cholesterol-lowering effect of statins is modified by LILRB5 intolerance genotype: Results from a recruit-by-genotype clinical trial
por: Tornio, Aleksi, et al.
Publicado: (2023)

Lipoprotein‐associated phospholipase A2: The story continues
por: Huang, Fubao, et al.
Publicado: (2019)

A phenome-wide association study of a lipoprotein-associated phospholipase A(2) loss-of-function variant in 90 000 Chinese adults
por: Millwood, Iona Y, et al.
Publicado: (2016)

Lipoprotein-associated phospholipase A2, homocysteine, and Alzheimer's disease
por: Doody, Rachelle S., et al.
Publicado: (2015)

Efficacy of Modern Diabetes Treatments DPP-4i, SGLT-2i, and GLP-1RA in White and Asian Patients With Diabetes: A Systematic Review and Meta-analysis of Randomized Controlled Trials
por: Gan, Sushrima, et al.
Publicado: (2020)

Response to Comment on Gan et al. Efficacy of Modern Diabetes Treatments DPP-4i, SGLT-2i, and GLP-1RA in White and Asian Patients With Diabetes: A Systematic Review and Meta-analysis of Randomized Controlled Trials. Diabetes Care 2020;43:1948–1957
por: Gan, Sushrima, et al.
Publicado: (2020)

Racial variation in lipoprotein-associated phospholipase A(2 )in older adults
por: Lee, Keane K, et al.
Publicado: (2011)

Secreted phospholipase A(2), lipoprotein hydrolysis, and atherosclerosis: integration with lipidomics
por: Yamamoto, Kei, et al.
Publicado: (2011)

Elevated Lipoprotein-Associated Phospholipase A2 Is Associated With Intracranial Atherosclerosis
por: Wang, Yuan, et al.
Publicado: (2022)

Lipoprotein-Associated Phospholipase A(2) Mass Level Is Increased in Elderly Subjects with Type 2 Diabetes Mellitus
por: Fortunato, J., et al.
Publicado: (2014)

Lipoprotein-Associated Phospholipase A(2), Vascular Inflammation and Cardiovascular Risk Prediction
por: Sudhir, Krishnankutty
Publicado: (2006)

Is lipoprotein-associated phospholipase A(2) correlated with cardiovascular risk in European women?
por: Hirschler, V.
Publicado: (2013)

Interleukin-6 and lipoprotein-associated phospholipase A2 are associated with functional trajectories
por: Dhamoon, Mandip S., et al.
Publicado: (2019)

The correlation between lipoprotein associated phospholipase A(2) and central overweight status
por: Chen, Yi-Hsuan, et al.
Publicado: (2021)

Lipoprotein-associated phospholipase A(2): A paradigm for allosteric regulation by membranes
por: Mouchlis, Varnavas D., et al.
Publicado: (2022)

Lipoprotein-Associated Phospholipase A2 Activity as Potential Biomarker of Vascular Dementia
por: Zuliani, Giovanni, et al.
Publicado: (2023)

The diagnostic value of lipoprotein-associated phospholipase A2 in early diabetic nephropathy
por: Zhai, Yan, et al.
Publicado: (2023)

Lipoprotein-associated phospholipase A2 and oxidized low-density lipoprotein in young patients with acute coronary syndrome in China
por: Huang, Yuli, et al.
Publicado: (2017)

Elevated lipoprotein(a) and lipoprotein-associated phospholipase A(2) are associated with unfavorable functional outcomes in patients with ischemic stroke
por: Jiang, Xue, et al.
Publicado: (2021)

The impact of phenotype, ethnicity and genotype on progression of type 2 diabetes mellitus
por: Thakarakkattil Narayanan Nair, Anand, et al.
Publicado: (2020)

Active site competition is the mechanism for the inhibition of lipoprotein-associated phospholipase A(2) by detergent micelles or lipoproteins and for the efficacy reduction of darapladib
por: Zhuo, Shaoqiu, et al.
Publicado: (2020)

Plasma Lipoprotein-associated Phospholipase A2 in Patients with Metabolic Syndrome and Carotid Atherosclerosis
por: Gong, Hui-ping, et al.
Publicado: (2011)

Association of Lipoprotein-Associated Phospholipase A(2) with Characteristics of Vulnerable Coronary Atherosclerotic Plaques
por: Liu, Yu-Sheng, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_dkp3bvejrskrlv5fnv3a8s07p3