Cargando…

Sex differences in intraorgan fat levels and hepatic lipid metabolism: implications for cardiovascular health and remission of type 2 diabetes after dietary weight loss

AIMS/HYPOTHESIS: Type 2 diabetes confers a greater relative increase in CVD risk in women compared with men. We examined sex differences in intraorgan fat and hepatic VLDL1-triacylglycerol (VLDL1-TG) export before and after major dietary weight loss. METHODS: A group with type 2 diabetes (n = 64, 30...

Descripción completa

Detalles Bibliográficos
Autores principales: Jesuthasan, Aaron, Zhyzhneuskaya, Sviatlana, Peters, Carl, Barnes, Alison C., Hollingsworth, Kieren G., Sattar, Naveed, Lean, Michael E. J., Taylor, Roy, Al-Mrabeh, Ahmad H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8660759/
https://www.ncbi.nlm.nih.gov/pubmed/34657182
http://dx.doi.org/10.1007/s00125-021-05583-4
_version_ 1784613256783986688
author Jesuthasan, Aaron
Zhyzhneuskaya, Sviatlana
Peters, Carl
Barnes, Alison C.
Hollingsworth, Kieren G.
Sattar, Naveed
Lean, Michael E. J.
Taylor, Roy
Al-Mrabeh, Ahmad H.
author_facet Jesuthasan, Aaron
Zhyzhneuskaya, Sviatlana
Peters, Carl
Barnes, Alison C.
Hollingsworth, Kieren G.
Sattar, Naveed
Lean, Michael E. J.
Taylor, Roy
Al-Mrabeh, Ahmad H.
author_sort Jesuthasan, Aaron
collection PubMed
description AIMS/HYPOTHESIS: Type 2 diabetes confers a greater relative increase in CVD risk in women compared with men. We examined sex differences in intraorgan fat and hepatic VLDL1-triacylglycerol (VLDL1-TG) export before and after major dietary weight loss. METHODS: A group with type 2 diabetes (n = 64, 30 male/34 female) and a group of healthy individuals (n = 25, 13 male/12 female) were studied. Intraorgan and visceral fat were quantified by magnetic resonance and VLDL1-TG export by intralipid infusion techniques. RESULTS: Triacylglycerol content of the liver and pancreas was elevated in people with diabetes with no sex differences (liver 16.4% [9.3–25.0%] in women vs 11.9% [7.0–23.1%] in men, p = 0.57, and pancreas 8.3 ± 0.5% vs 8.5 ± 0.4%, p = 0.83, respectively). In the absence of diabetes, fat levels in both organs were lower in women than men (1.0% [0.9–1.7%] vs 4.5% [1.9–8.0%], p = 0.005, and 4.7 ± 0.4% vs 7.6 ± 0.5%, p< 0.0001, respectively). Women with diabetes had higher hepatic VLDL1-TG production rate and plasma VLDL1-TG than healthy women (559.3 ± 32.9 vs 403.2 ± 45.7 mg kg(−1) day(−1), p = 0.01, and 0.45 [0.26–0.77] vs 0.25 [0.13–0.33] mmol/l, p = 0.02), whereas there were no differences in men (548.8 ± 39.8 vs 506.7 ± 29.2 mg kg(−1) day(−1), p = 0.34, and 0.72 [0.53–1.15] vs 0.50 [0.32–0.68] mmol/l, p = 0.26). Weight loss decreased intraorgan fat and VLDL1-TG production rates regardless of sex, and these changes were accompanied by similar rates of diabetes remission (65.4% vs 71.0%) and CVD risk reduction (59.8% vs 41.5%) in women and men, respectively. CONCLUSIONS/INTERPRETATION: In type 2 diabetes, women have liver and pancreas fat levels as high as those of men, associated with raised hepatic VLDL1-TG production rates. Dynamics of triacylglycerol turnover differ between sexes in type 2 diabetes and following weight loss. These changes may contribute to the disproportionately raised cardiovascular risk of women with diabetes. GRAPHICAL ABSTRACT: [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains peer-reviewed but unedited supplementary material available at 10.1007/s00125-021-05583-4.
format Online
Article
Text
id pubmed-8660759
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Springer Berlin Heidelberg
record_format MEDLINE/PubMed
spelling pubmed-86607592021-12-27 Sex differences in intraorgan fat levels and hepatic lipid metabolism: implications for cardiovascular health and remission of type 2 diabetes after dietary weight loss Jesuthasan, Aaron Zhyzhneuskaya, Sviatlana Peters, Carl Barnes, Alison C. Hollingsworth, Kieren G. Sattar, Naveed Lean, Michael E. J. Taylor, Roy Al-Mrabeh, Ahmad H. Diabetologia Short Communication AIMS/HYPOTHESIS: Type 2 diabetes confers a greater relative increase in CVD risk in women compared with men. We examined sex differences in intraorgan fat and hepatic VLDL1-triacylglycerol (VLDL1-TG) export before and after major dietary weight loss. METHODS: A group with type 2 diabetes (n = 64, 30 male/34 female) and a group of healthy individuals (n = 25, 13 male/12 female) were studied. Intraorgan and visceral fat were quantified by magnetic resonance and VLDL1-TG export by intralipid infusion techniques. RESULTS: Triacylglycerol content of the liver and pancreas was elevated in people with diabetes with no sex differences (liver 16.4% [9.3–25.0%] in women vs 11.9% [7.0–23.1%] in men, p = 0.57, and pancreas 8.3 ± 0.5% vs 8.5 ± 0.4%, p = 0.83, respectively). In the absence of diabetes, fat levels in both organs were lower in women than men (1.0% [0.9–1.7%] vs 4.5% [1.9–8.0%], p = 0.005, and 4.7 ± 0.4% vs 7.6 ± 0.5%, p< 0.0001, respectively). Women with diabetes had higher hepatic VLDL1-TG production rate and plasma VLDL1-TG than healthy women (559.3 ± 32.9 vs 403.2 ± 45.7 mg kg(−1) day(−1), p = 0.01, and 0.45 [0.26–0.77] vs 0.25 [0.13–0.33] mmol/l, p = 0.02), whereas there were no differences in men (548.8 ± 39.8 vs 506.7 ± 29.2 mg kg(−1) day(−1), p = 0.34, and 0.72 [0.53–1.15] vs 0.50 [0.32–0.68] mmol/l, p = 0.26). Weight loss decreased intraorgan fat and VLDL1-TG production rates regardless of sex, and these changes were accompanied by similar rates of diabetes remission (65.4% vs 71.0%) and CVD risk reduction (59.8% vs 41.5%) in women and men, respectively. CONCLUSIONS/INTERPRETATION: In type 2 diabetes, women have liver and pancreas fat levels as high as those of men, associated with raised hepatic VLDL1-TG production rates. Dynamics of triacylglycerol turnover differ between sexes in type 2 diabetes and following weight loss. These changes may contribute to the disproportionately raised cardiovascular risk of women with diabetes. GRAPHICAL ABSTRACT: [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains peer-reviewed but unedited supplementary material available at 10.1007/s00125-021-05583-4. Springer Berlin Heidelberg 2021-10-16 2022 /pmc/articles/PMC8660759/ /pubmed/34657182 http://dx.doi.org/10.1007/s00125-021-05583-4 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Short Communication
Jesuthasan, Aaron
Zhyzhneuskaya, Sviatlana
Peters, Carl
Barnes, Alison C.
Hollingsworth, Kieren G.
Sattar, Naveed
Lean, Michael E. J.
Taylor, Roy
Al-Mrabeh, Ahmad H.
Sex differences in intraorgan fat levels and hepatic lipid metabolism: implications for cardiovascular health and remission of type 2 diabetes after dietary weight loss
title Sex differences in intraorgan fat levels and hepatic lipid metabolism: implications for cardiovascular health and remission of type 2 diabetes after dietary weight loss
title_full Sex differences in intraorgan fat levels and hepatic lipid metabolism: implications for cardiovascular health and remission of type 2 diabetes after dietary weight loss
title_fullStr Sex differences in intraorgan fat levels and hepatic lipid metabolism: implications for cardiovascular health and remission of type 2 diabetes after dietary weight loss
title_full_unstemmed Sex differences in intraorgan fat levels and hepatic lipid metabolism: implications for cardiovascular health and remission of type 2 diabetes after dietary weight loss
title_short Sex differences in intraorgan fat levels and hepatic lipid metabolism: implications for cardiovascular health and remission of type 2 diabetes after dietary weight loss
title_sort sex differences in intraorgan fat levels and hepatic lipid metabolism: implications for cardiovascular health and remission of type 2 diabetes after dietary weight loss
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8660759/
https://www.ncbi.nlm.nih.gov/pubmed/34657182
http://dx.doi.org/10.1007/s00125-021-05583-4
work_keys_str_mv AT jesuthasanaaron sexdifferencesinintraorganfatlevelsandhepaticlipidmetabolismimplicationsforcardiovascularhealthandremissionoftype2diabetesafterdietaryweightloss
AT zhyzhneuskayasviatlana sexdifferencesinintraorganfatlevelsandhepaticlipidmetabolismimplicationsforcardiovascularhealthandremissionoftype2diabetesafterdietaryweightloss
AT peterscarl sexdifferencesinintraorganfatlevelsandhepaticlipidmetabolismimplicationsforcardiovascularhealthandremissionoftype2diabetesafterdietaryweightloss
AT barnesalisonc sexdifferencesinintraorganfatlevelsandhepaticlipidmetabolismimplicationsforcardiovascularhealthandremissionoftype2diabetesafterdietaryweightloss
AT hollingsworthkiereng sexdifferencesinintraorganfatlevelsandhepaticlipidmetabolismimplicationsforcardiovascularhealthandremissionoftype2diabetesafterdietaryweightloss
AT sattarnaveed sexdifferencesinintraorganfatlevelsandhepaticlipidmetabolismimplicationsforcardiovascularhealthandremissionoftype2diabetesafterdietaryweightloss
AT leanmichaelej sexdifferencesinintraorganfatlevelsandhepaticlipidmetabolismimplicationsforcardiovascularhealthandremissionoftype2diabetesafterdietaryweightloss
AT taylorroy sexdifferencesinintraorganfatlevelsandhepaticlipidmetabolismimplicationsforcardiovascularhealthandremissionoftype2diabetesafterdietaryweightloss
AT almrabehahmadh sexdifferencesinintraorganfatlevelsandhepaticlipidmetabolismimplicationsforcardiovascularhealthandremissionoftype2diabetesafterdietaryweightloss