Cargando…
Theranostic near-infrared-IIb emitting nanoprobes for promoting immunogenic radiotherapy and abscopal effects against cancer metastasis
Radiotherapy is an important therapeutic strategy for cancer treatment through direct damage to cancer cells and augmentation of antitumor immune responses. However, the efficacy of radiotherapy is limited by hypoxia-mediated radioresistance and immunosuppression in tumor microenvironment. Here, we...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8660774/ https://www.ncbi.nlm.nih.gov/pubmed/34887404 http://dx.doi.org/10.1038/s41467-021-27485-0 |
_version_ | 1784613260450856960 |
---|---|
author | Li, Hao Wang, Meng Huang, Biao Zhu, Su-Wen Zhou, Jun-Jie Chen, De-Run Cui, Ran Zhang, Mingxi Sun, Zhi-Jun |
author_facet | Li, Hao Wang, Meng Huang, Biao Zhu, Su-Wen Zhou, Jun-Jie Chen, De-Run Cui, Ran Zhang, Mingxi Sun, Zhi-Jun |
author_sort | Li, Hao |
collection | PubMed |
description | Radiotherapy is an important therapeutic strategy for cancer treatment through direct damage to cancer cells and augmentation of antitumor immune responses. However, the efficacy of radiotherapy is limited by hypoxia-mediated radioresistance and immunosuppression in tumor microenvironment. Here, we construct a stabilized theranostic nanoprobe based on quantum dots emitting in the near-infrared IIb (NIR-IIb, 1,500–1,700 nm) window modified by catalase, arginine–glycine–aspartate peptides and poly(ethylene glycol). We demonstrate that the nanoprobes effectively aggregate in the tumor site to locate the tumor region, thereby realizing precision radiotherapy with few side-effects. In addition, nanoprobes relieve intratumoral hypoxia and reduce the tumor infiltration of immunosuppressive cells. Moreover, the nanoprobes promote the immunogenic cell death of cancer cells to trigger the activation of dendritic cells and enhance T cell-mediated antitumor immunity to inhibit tumor metastasis. Collectively, the nanoprobe-mediated immunogenic radiotherapy can boost the abscopal effect to inhibit tumor metastasis and prolong survival. |
format | Online Article Text |
id | pubmed-8660774 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-86607742021-12-27 Theranostic near-infrared-IIb emitting nanoprobes for promoting immunogenic radiotherapy and abscopal effects against cancer metastasis Li, Hao Wang, Meng Huang, Biao Zhu, Su-Wen Zhou, Jun-Jie Chen, De-Run Cui, Ran Zhang, Mingxi Sun, Zhi-Jun Nat Commun Article Radiotherapy is an important therapeutic strategy for cancer treatment through direct damage to cancer cells and augmentation of antitumor immune responses. However, the efficacy of radiotherapy is limited by hypoxia-mediated radioresistance and immunosuppression in tumor microenvironment. Here, we construct a stabilized theranostic nanoprobe based on quantum dots emitting in the near-infrared IIb (NIR-IIb, 1,500–1,700 nm) window modified by catalase, arginine–glycine–aspartate peptides and poly(ethylene glycol). We demonstrate that the nanoprobes effectively aggregate in the tumor site to locate the tumor region, thereby realizing precision radiotherapy with few side-effects. In addition, nanoprobes relieve intratumoral hypoxia and reduce the tumor infiltration of immunosuppressive cells. Moreover, the nanoprobes promote the immunogenic cell death of cancer cells to trigger the activation of dendritic cells and enhance T cell-mediated antitumor immunity to inhibit tumor metastasis. Collectively, the nanoprobe-mediated immunogenic radiotherapy can boost the abscopal effect to inhibit tumor metastasis and prolong survival. Nature Publishing Group UK 2021-12-09 /pmc/articles/PMC8660774/ /pubmed/34887404 http://dx.doi.org/10.1038/s41467-021-27485-0 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Li, Hao Wang, Meng Huang, Biao Zhu, Su-Wen Zhou, Jun-Jie Chen, De-Run Cui, Ran Zhang, Mingxi Sun, Zhi-Jun Theranostic near-infrared-IIb emitting nanoprobes for promoting immunogenic radiotherapy and abscopal effects against cancer metastasis |
title | Theranostic near-infrared-IIb emitting nanoprobes for promoting immunogenic radiotherapy and abscopal effects against cancer metastasis |
title_full | Theranostic near-infrared-IIb emitting nanoprobes for promoting immunogenic radiotherapy and abscopal effects against cancer metastasis |
title_fullStr | Theranostic near-infrared-IIb emitting nanoprobes for promoting immunogenic radiotherapy and abscopal effects against cancer metastasis |
title_full_unstemmed | Theranostic near-infrared-IIb emitting nanoprobes for promoting immunogenic radiotherapy and abscopal effects against cancer metastasis |
title_short | Theranostic near-infrared-IIb emitting nanoprobes for promoting immunogenic radiotherapy and abscopal effects against cancer metastasis |
title_sort | theranostic near-infrared-iib emitting nanoprobes for promoting immunogenic radiotherapy and abscopal effects against cancer metastasis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8660774/ https://www.ncbi.nlm.nih.gov/pubmed/34887404 http://dx.doi.org/10.1038/s41467-021-27485-0 |
work_keys_str_mv | AT lihao theranosticnearinfrarediibemittingnanoprobesforpromotingimmunogenicradiotherapyandabscopaleffectsagainstcancermetastasis AT wangmeng theranosticnearinfrarediibemittingnanoprobesforpromotingimmunogenicradiotherapyandabscopaleffectsagainstcancermetastasis AT huangbiao theranosticnearinfrarediibemittingnanoprobesforpromotingimmunogenicradiotherapyandabscopaleffectsagainstcancermetastasis AT zhusuwen theranosticnearinfrarediibemittingnanoprobesforpromotingimmunogenicradiotherapyandabscopaleffectsagainstcancermetastasis AT zhoujunjie theranosticnearinfrarediibemittingnanoprobesforpromotingimmunogenicradiotherapyandabscopaleffectsagainstcancermetastasis AT chenderun theranosticnearinfrarediibemittingnanoprobesforpromotingimmunogenicradiotherapyandabscopaleffectsagainstcancermetastasis AT cuiran theranosticnearinfrarediibemittingnanoprobesforpromotingimmunogenicradiotherapyandabscopaleffectsagainstcancermetastasis AT zhangmingxi theranosticnearinfrarediibemittingnanoprobesforpromotingimmunogenicradiotherapyandabscopaleffectsagainstcancermetastasis AT sunzhijun theranosticnearinfrarediibemittingnanoprobesforpromotingimmunogenicradiotherapyandabscopaleffectsagainstcancermetastasis |