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dbTMM: an integrated database of large-scale cohort, genome and clinical data for the Tohoku Medical Megabank Project
To reveal gene-environment interactions underlying common diseases and estimate the risk for common diseases, the Tohoku Medical Megabank (TMM) project has conducted prospective cohort studies and genomic and multiomics analyses. To establish an integrated biobank, we developed an integrated databas...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8660797/ https://www.ncbi.nlm.nih.gov/pubmed/34887386 http://dx.doi.org/10.1038/s41439-021-00175-5 |
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| author | Ogishima, Soichi Nagaie, Satoshi Mizuno, Satoshi Ishiwata, Ryosuke Iida, Keita Shimokawa, Kazuro Takai-Igarashi, Takako Nakamura, Naoki Nagase, Sachiko Nakamura, Tomohiro Tsuchiya, Naho Nakaya, Naoki Murakami, Keiko Ueno, Fumihiko Onuma, Tomomi Ishikuro, Mami Obara, Taku Mugikura, Shunji Tomita, Hiroaki Uruno, Akira Kobayashi, Tomoko Tsuboi, Akito Tadaka, Shu Katsuoka, Fumiki Narita, Akira Sakurai, Mika Makino, Satoshi Tamiya, Gen Aoki, Yuichi Shimizu, Ritsuko Motoike, Ikuko N. Koshiba, Seizo Minegishi, Naoko Kumada, Kazuki Nobukuni, Takahiro Suzuki, Kichiya Danjoh, Inaho Nagami, Fuji Tanno, Kozo Ohmomo, Hideki Asahi, Koichi Shimizu, Atsushi Hozawa, Atsushi Kuriyama, Shinichi Fuse, Nobuo Tominaga, Teiji Kure, Shigeo Yaegashi, Nobuo Kinoshita, Kengo Sasaki, Makoto Tanaka, Hiroshi Yamamoto, Masayuki |
| author_facet | Ogishima, Soichi Nagaie, Satoshi Mizuno, Satoshi Ishiwata, Ryosuke Iida, Keita Shimokawa, Kazuro Takai-Igarashi, Takako Nakamura, Naoki Nagase, Sachiko Nakamura, Tomohiro Tsuchiya, Naho Nakaya, Naoki Murakami, Keiko Ueno, Fumihiko Onuma, Tomomi Ishikuro, Mami Obara, Taku Mugikura, Shunji Tomita, Hiroaki Uruno, Akira Kobayashi, Tomoko Tsuboi, Akito Tadaka, Shu Katsuoka, Fumiki Narita, Akira Sakurai, Mika Makino, Satoshi Tamiya, Gen Aoki, Yuichi Shimizu, Ritsuko Motoike, Ikuko N. Koshiba, Seizo Minegishi, Naoko Kumada, Kazuki Nobukuni, Takahiro Suzuki, Kichiya Danjoh, Inaho Nagami, Fuji Tanno, Kozo Ohmomo, Hideki Asahi, Koichi Shimizu, Atsushi Hozawa, Atsushi Kuriyama, Shinichi Fuse, Nobuo Tominaga, Teiji Kure, Shigeo Yaegashi, Nobuo Kinoshita, Kengo Sasaki, Makoto Tanaka, Hiroshi Yamamoto, Masayuki |
| author_sort | Ogishima, Soichi |
| collection | PubMed |
| description | To reveal gene-environment interactions underlying common diseases and estimate the risk for common diseases, the Tohoku Medical Megabank (TMM) project has conducted prospective cohort studies and genomic and multiomics analyses. To establish an integrated biobank, we developed an integrated database called “dbTMM” that incorporates both the individual cohort/clinical data and the genome/multiomics data of 157,191 participants in the Tohoku Medical Megabank project. To our knowledge, dbTMM is the first database to store individual whole-genome data on a variant-by-variant basis as well as cohort/clinical data for over one hundred thousand participants in a prospective cohort study. dbTMM enables us to stratify our cohort by both genome-wide genetic factors and environmental factors, and it provides a research and development platform that enables prospective analysis of large-scale data from genome cohorts. |
| format | Online Article Text |
| id | pubmed-8660797 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2021 |
| publisher | Nature Publishing Group UK |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-86607972021-12-27 dbTMM: an integrated database of large-scale cohort, genome and clinical data for the Tohoku Medical Megabank Project Ogishima, Soichi Nagaie, Satoshi Mizuno, Satoshi Ishiwata, Ryosuke Iida, Keita Shimokawa, Kazuro Takai-Igarashi, Takako Nakamura, Naoki Nagase, Sachiko Nakamura, Tomohiro Tsuchiya, Naho Nakaya, Naoki Murakami, Keiko Ueno, Fumihiko Onuma, Tomomi Ishikuro, Mami Obara, Taku Mugikura, Shunji Tomita, Hiroaki Uruno, Akira Kobayashi, Tomoko Tsuboi, Akito Tadaka, Shu Katsuoka, Fumiki Narita, Akira Sakurai, Mika Makino, Satoshi Tamiya, Gen Aoki, Yuichi Shimizu, Ritsuko Motoike, Ikuko N. Koshiba, Seizo Minegishi, Naoko Kumada, Kazuki Nobukuni, Takahiro Suzuki, Kichiya Danjoh, Inaho Nagami, Fuji Tanno, Kozo Ohmomo, Hideki Asahi, Koichi Shimizu, Atsushi Hozawa, Atsushi Kuriyama, Shinichi Fuse, Nobuo Tominaga, Teiji Kure, Shigeo Yaegashi, Nobuo Kinoshita, Kengo Sasaki, Makoto Tanaka, Hiroshi Yamamoto, Masayuki Hum Genome Var Article To reveal gene-environment interactions underlying common diseases and estimate the risk for common diseases, the Tohoku Medical Megabank (TMM) project has conducted prospective cohort studies and genomic and multiomics analyses. To establish an integrated biobank, we developed an integrated database called “dbTMM” that incorporates both the individual cohort/clinical data and the genome/multiomics data of 157,191 participants in the Tohoku Medical Megabank project. To our knowledge, dbTMM is the first database to store individual whole-genome data on a variant-by-variant basis as well as cohort/clinical data for over one hundred thousand participants in a prospective cohort study. dbTMM enables us to stratify our cohort by both genome-wide genetic factors and environmental factors, and it provides a research and development platform that enables prospective analysis of large-scale data from genome cohorts. Nature Publishing Group UK 2021-12-10 /pmc/articles/PMC8660797/ /pubmed/34887386 http://dx.doi.org/10.1038/s41439-021-00175-5 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
| spellingShingle | Article Ogishima, Soichi Nagaie, Satoshi Mizuno, Satoshi Ishiwata, Ryosuke Iida, Keita Shimokawa, Kazuro Takai-Igarashi, Takako Nakamura, Naoki Nagase, Sachiko Nakamura, Tomohiro Tsuchiya, Naho Nakaya, Naoki Murakami, Keiko Ueno, Fumihiko Onuma, Tomomi Ishikuro, Mami Obara, Taku Mugikura, Shunji Tomita, Hiroaki Uruno, Akira Kobayashi, Tomoko Tsuboi, Akito Tadaka, Shu Katsuoka, Fumiki Narita, Akira Sakurai, Mika Makino, Satoshi Tamiya, Gen Aoki, Yuichi Shimizu, Ritsuko Motoike, Ikuko N. Koshiba, Seizo Minegishi, Naoko Kumada, Kazuki Nobukuni, Takahiro Suzuki, Kichiya Danjoh, Inaho Nagami, Fuji Tanno, Kozo Ohmomo, Hideki Asahi, Koichi Shimizu, Atsushi Hozawa, Atsushi Kuriyama, Shinichi Fuse, Nobuo Tominaga, Teiji Kure, Shigeo Yaegashi, Nobuo Kinoshita, Kengo Sasaki, Makoto Tanaka, Hiroshi Yamamoto, Masayuki dbTMM: an integrated database of large-scale cohort, genome and clinical data for the Tohoku Medical Megabank Project |
| title | dbTMM: an integrated database of large-scale cohort, genome and clinical data for the Tohoku Medical Megabank Project |
| title_full | dbTMM: an integrated database of large-scale cohort, genome and clinical data for the Tohoku Medical Megabank Project |
| title_fullStr | dbTMM: an integrated database of large-scale cohort, genome and clinical data for the Tohoku Medical Megabank Project |
| title_full_unstemmed | dbTMM: an integrated database of large-scale cohort, genome and clinical data for the Tohoku Medical Megabank Project |
| title_short | dbTMM: an integrated database of large-scale cohort, genome and clinical data for the Tohoku Medical Megabank Project |
| title_sort | dbtmm: an integrated database of large-scale cohort, genome and clinical data for the tohoku medical megabank project |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8660797/ https://www.ncbi.nlm.nih.gov/pubmed/34887386 http://dx.doi.org/10.1038/s41439-021-00175-5 |
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