Strategies to package recombinant Adeno-Associated Virus expressing the N-terminal gasdermin domain for tumor treatment

Pyroptosis induced by the N-terminal gasdermin domain (GSDM(NT)) holds great potential for anti-tumor therapy. However, due to the extreme cytoxicity of GSDM(NT), it is challenging to efficiently produce and deliver GSDM(NT) into tumor cells. Here, we report the development of two strategies to pack...

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Detalles Bibliográficos
Autores principales: Lu, Yuan, He, Wenbo, Huang, Xin, He, Yu, Gou, Xiaojuan, Liu, Xiaoke, Hu, Zhe, Xu, Weize, Rahman, Khaista, Li, Shan, Hu, Sheng, Luo, Jie, Cao, Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8660823/
https://www.ncbi.nlm.nih.gov/pubmed/34887423
http://dx.doi.org/10.1038/s41467-021-27407-0

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