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Meta-analyses identify DNA methylation associated with kidney function and damage
Chronic kidney disease is a major public health burden. Elevated urinary albumin-to-creatinine ratio is a measure of kidney damage, and used to diagnose and stage chronic kidney disease. To extend the knowledge on regulatory mechanisms related to kidney function and disease, we conducted a blood-bas...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8660832/ https://www.ncbi.nlm.nih.gov/pubmed/34887417 http://dx.doi.org/10.1038/s41467-021-27234-3 |
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| author | Schlosser, Pascal Tin, Adrienne Matias-Garcia, Pamela R. Thio, Chris H. L. Joehanes, Roby Liu, Hongbo Weihs, Antoine Yu, Zhi Hoppmann, Anselm Grundner-Culemann, Franziska Min, Josine L. Adeyemo, Adebowale A. Agyemang, Charles Ärnlöv, Johan Aziz, Nasir A. Baccarelli, Andrea Bochud, Murielle Brenner, Hermann Breteler, Monique M. B. Carmeli, Cristian Chaker, Layal Chambers, John C. Cole, Shelley A. Coresh, Josef Corre, Tanguy Correa, Adolfo Cox, Simon R. de Klein, Niek Delgado, Graciela E. Domingo-Relloso, Arce Eckardt, Kai-Uwe Ekici, Arif B. Endlich, Karlhans Evans, Kathryn L. Floyd, James S. Fornage, Myriam Franke, Lude Fraszczyk, Eliza Gao, Xu Gào, Xīn Ghanbari, Mohsen Ghasemi, Sahar Gieger, Christian Greenland, Philip Grove, Megan L. Harris, Sarah E. Hemani, Gibran Henneman, Peter Herder, Christian Horvath, Steve Hou, Lifang Hurme, Mikko A. Hwang, Shih-Jen Jarvelin, Marjo-Riitta Kardia, Sharon L. R. Kasela, Silva Kleber, Marcus E. Koenig, Wolfgang Kooner, Jaspal S. Kramer, Holly Kronenberg, Florian Kühnel, Brigitte Lehtimäki, Terho Lind, Lars Liu, Dan Liu, Yongmei Lloyd-Jones, Donald M. Lohman, Kurt Lorkowski, Stefan Lu, Ake T. Marioni, Riccardo E. März, Winfried McCartney, Daniel L. Meeks, Karlijn A. C. Milani, Lili Mishra, Pashupati P. Nauck, Matthias Navas-Acien, Ana Nowak, Christoph Peters, Annette Prokisch, Holger Psaty, Bruce M. Raitakari, Olli T. Ratliff, Scott M. Reiner, Alex P. Rosas, Sylvia E. Schöttker, Ben Schwartz, Joel Sedaghat, Sanaz Smith, Jennifer A. Sotoodehnia, Nona Stocker, Hannah R. Stringhini, Silvia Sundström, Johan Swenson, Brenton R. Tellez-Plaza, Maria van Meurs, Joyce B. J. van Vliet-Ostaptchouk, Jana V. Venema, Andrea Verweij, Niek Walker, Rosie M. Wielscher, Matthias Winkelmann, Juliane Wolffenbuttel, Bruce H. R. Zhao, Wei Zheng, Yinan Loh, Marie Snieder, Harold Levy, Daniel Waldenberger, Melanie Susztak, Katalin Köttgen, Anna Teumer, Alexander |
| author_facet | Schlosser, Pascal Tin, Adrienne Matias-Garcia, Pamela R. Thio, Chris H. L. Joehanes, Roby Liu, Hongbo Weihs, Antoine Yu, Zhi Hoppmann, Anselm Grundner-Culemann, Franziska Min, Josine L. Adeyemo, Adebowale A. Agyemang, Charles Ärnlöv, Johan Aziz, Nasir A. Baccarelli, Andrea Bochud, Murielle Brenner, Hermann Breteler, Monique M. B. Carmeli, Cristian Chaker, Layal Chambers, John C. Cole, Shelley A. Coresh, Josef Corre, Tanguy Correa, Adolfo Cox, Simon R. de Klein, Niek Delgado, Graciela E. Domingo-Relloso, Arce Eckardt, Kai-Uwe Ekici, Arif B. Endlich, Karlhans Evans, Kathryn L. Floyd, James S. Fornage, Myriam Franke, Lude Fraszczyk, Eliza Gao, Xu Gào, Xīn Ghanbari, Mohsen Ghasemi, Sahar Gieger, Christian Greenland, Philip Grove, Megan L. Harris, Sarah E. Hemani, Gibran Henneman, Peter Herder, Christian Horvath, Steve Hou, Lifang Hurme, Mikko A. Hwang, Shih-Jen Jarvelin, Marjo-Riitta Kardia, Sharon L. R. Kasela, Silva Kleber, Marcus E. Koenig, Wolfgang Kooner, Jaspal S. Kramer, Holly Kronenberg, Florian Kühnel, Brigitte Lehtimäki, Terho Lind, Lars Liu, Dan Liu, Yongmei Lloyd-Jones, Donald M. Lohman, Kurt Lorkowski, Stefan Lu, Ake T. Marioni, Riccardo E. März, Winfried McCartney, Daniel L. Meeks, Karlijn A. C. Milani, Lili Mishra, Pashupati P. Nauck, Matthias Navas-Acien, Ana Nowak, Christoph Peters, Annette Prokisch, Holger Psaty, Bruce M. Raitakari, Olli T. Ratliff, Scott M. Reiner, Alex P. Rosas, Sylvia E. Schöttker, Ben Schwartz, Joel Sedaghat, Sanaz Smith, Jennifer A. Sotoodehnia, Nona Stocker, Hannah R. Stringhini, Silvia Sundström, Johan Swenson, Brenton R. Tellez-Plaza, Maria van Meurs, Joyce B. J. van Vliet-Ostaptchouk, Jana V. Venema, Andrea Verweij, Niek Walker, Rosie M. Wielscher, Matthias Winkelmann, Juliane Wolffenbuttel, Bruce H. R. Zhao, Wei Zheng, Yinan Loh, Marie Snieder, Harold Levy, Daniel Waldenberger, Melanie Susztak, Katalin Köttgen, Anna Teumer, Alexander |
| author_sort | Schlosser, Pascal |
| collection | PubMed |
| description | Chronic kidney disease is a major public health burden. Elevated urinary albumin-to-creatinine ratio is a measure of kidney damage, and used to diagnose and stage chronic kidney disease. To extend the knowledge on regulatory mechanisms related to kidney function and disease, we conducted a blood-based epigenome-wide association study for estimated glomerular filtration rate (n = 33,605) and urinary albumin-to-creatinine ratio (n = 15,068) and detected 69 and seven CpG sites where DNA methylation was associated with the respective trait. The majority of these findings showed directionally consistent associations with the respective clinical outcomes chronic kidney disease and moderately increased albuminuria. Associations of DNA methylation with kidney function, such as CpGs at JAZF1, PELI1 and CHD2 were validated in kidney tissue. Methylation at PHRF1, LDB2, CSRNP1 and IRF5 indicated causal effects on kidney function. Enrichment analyses revealed pathways related to hemostasis and blood cell migration for estimated glomerular filtration rate, and immune cell activation and response for urinary albumin-to-creatinineratio-associated CpGs. |
| format | Online Article Text |
| id | pubmed-8660832 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2021 |
| publisher | Nature Publishing Group UK |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-86608322021-12-27 Meta-analyses identify DNA methylation associated with kidney function and damage Schlosser, Pascal Tin, Adrienne Matias-Garcia, Pamela R. Thio, Chris H. L. Joehanes, Roby Liu, Hongbo Weihs, Antoine Yu, Zhi Hoppmann, Anselm Grundner-Culemann, Franziska Min, Josine L. Adeyemo, Adebowale A. Agyemang, Charles Ärnlöv, Johan Aziz, Nasir A. Baccarelli, Andrea Bochud, Murielle Brenner, Hermann Breteler, Monique M. B. Carmeli, Cristian Chaker, Layal Chambers, John C. Cole, Shelley A. Coresh, Josef Corre, Tanguy Correa, Adolfo Cox, Simon R. de Klein, Niek Delgado, Graciela E. Domingo-Relloso, Arce Eckardt, Kai-Uwe Ekici, Arif B. Endlich, Karlhans Evans, Kathryn L. Floyd, James S. Fornage, Myriam Franke, Lude Fraszczyk, Eliza Gao, Xu Gào, Xīn Ghanbari, Mohsen Ghasemi, Sahar Gieger, Christian Greenland, Philip Grove, Megan L. Harris, Sarah E. Hemani, Gibran Henneman, Peter Herder, Christian Horvath, Steve Hou, Lifang Hurme, Mikko A. Hwang, Shih-Jen Jarvelin, Marjo-Riitta Kardia, Sharon L. R. Kasela, Silva Kleber, Marcus E. Koenig, Wolfgang Kooner, Jaspal S. Kramer, Holly Kronenberg, Florian Kühnel, Brigitte Lehtimäki, Terho Lind, Lars Liu, Dan Liu, Yongmei Lloyd-Jones, Donald M. Lohman, Kurt Lorkowski, Stefan Lu, Ake T. Marioni, Riccardo E. März, Winfried McCartney, Daniel L. Meeks, Karlijn A. C. Milani, Lili Mishra, Pashupati P. Nauck, Matthias Navas-Acien, Ana Nowak, Christoph Peters, Annette Prokisch, Holger Psaty, Bruce M. Raitakari, Olli T. Ratliff, Scott M. Reiner, Alex P. Rosas, Sylvia E. Schöttker, Ben Schwartz, Joel Sedaghat, Sanaz Smith, Jennifer A. Sotoodehnia, Nona Stocker, Hannah R. Stringhini, Silvia Sundström, Johan Swenson, Brenton R. Tellez-Plaza, Maria van Meurs, Joyce B. J. van Vliet-Ostaptchouk, Jana V. Venema, Andrea Verweij, Niek Walker, Rosie M. Wielscher, Matthias Winkelmann, Juliane Wolffenbuttel, Bruce H. R. Zhao, Wei Zheng, Yinan Loh, Marie Snieder, Harold Levy, Daniel Waldenberger, Melanie Susztak, Katalin Köttgen, Anna Teumer, Alexander Nat Commun Article Chronic kidney disease is a major public health burden. Elevated urinary albumin-to-creatinine ratio is a measure of kidney damage, and used to diagnose and stage chronic kidney disease. To extend the knowledge on regulatory mechanisms related to kidney function and disease, we conducted a blood-based epigenome-wide association study for estimated glomerular filtration rate (n = 33,605) and urinary albumin-to-creatinine ratio (n = 15,068) and detected 69 and seven CpG sites where DNA methylation was associated with the respective trait. The majority of these findings showed directionally consistent associations with the respective clinical outcomes chronic kidney disease and moderately increased albuminuria. Associations of DNA methylation with kidney function, such as CpGs at JAZF1, PELI1 and CHD2 were validated in kidney tissue. Methylation at PHRF1, LDB2, CSRNP1 and IRF5 indicated causal effects on kidney function. Enrichment analyses revealed pathways related to hemostasis and blood cell migration for estimated glomerular filtration rate, and immune cell activation and response for urinary albumin-to-creatinineratio-associated CpGs. Nature Publishing Group UK 2021-12-09 /pmc/articles/PMC8660832/ /pubmed/34887417 http://dx.doi.org/10.1038/s41467-021-27234-3 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
| spellingShingle | Article Schlosser, Pascal Tin, Adrienne Matias-Garcia, Pamela R. Thio, Chris H. L. Joehanes, Roby Liu, Hongbo Weihs, Antoine Yu, Zhi Hoppmann, Anselm Grundner-Culemann, Franziska Min, Josine L. Adeyemo, Adebowale A. Agyemang, Charles Ärnlöv, Johan Aziz, Nasir A. Baccarelli, Andrea Bochud, Murielle Brenner, Hermann Breteler, Monique M. B. Carmeli, Cristian Chaker, Layal Chambers, John C. Cole, Shelley A. Coresh, Josef Corre, Tanguy Correa, Adolfo Cox, Simon R. de Klein, Niek Delgado, Graciela E. Domingo-Relloso, Arce Eckardt, Kai-Uwe Ekici, Arif B. Endlich, Karlhans Evans, Kathryn L. Floyd, James S. Fornage, Myriam Franke, Lude Fraszczyk, Eliza Gao, Xu Gào, Xīn Ghanbari, Mohsen Ghasemi, Sahar Gieger, Christian Greenland, Philip Grove, Megan L. Harris, Sarah E. Hemani, Gibran Henneman, Peter Herder, Christian Horvath, Steve Hou, Lifang Hurme, Mikko A. Hwang, Shih-Jen Jarvelin, Marjo-Riitta Kardia, Sharon L. R. Kasela, Silva Kleber, Marcus E. Koenig, Wolfgang Kooner, Jaspal S. Kramer, Holly Kronenberg, Florian Kühnel, Brigitte Lehtimäki, Terho Lind, Lars Liu, Dan Liu, Yongmei Lloyd-Jones, Donald M. Lohman, Kurt Lorkowski, Stefan Lu, Ake T. Marioni, Riccardo E. März, Winfried McCartney, Daniel L. Meeks, Karlijn A. C. Milani, Lili Mishra, Pashupati P. Nauck, Matthias Navas-Acien, Ana Nowak, Christoph Peters, Annette Prokisch, Holger Psaty, Bruce M. Raitakari, Olli T. Ratliff, Scott M. Reiner, Alex P. Rosas, Sylvia E. Schöttker, Ben Schwartz, Joel Sedaghat, Sanaz Smith, Jennifer A. Sotoodehnia, Nona Stocker, Hannah R. Stringhini, Silvia Sundström, Johan Swenson, Brenton R. Tellez-Plaza, Maria van Meurs, Joyce B. J. van Vliet-Ostaptchouk, Jana V. Venema, Andrea Verweij, Niek Walker, Rosie M. Wielscher, Matthias Winkelmann, Juliane Wolffenbuttel, Bruce H. R. Zhao, Wei Zheng, Yinan Loh, Marie Snieder, Harold Levy, Daniel Waldenberger, Melanie Susztak, Katalin Köttgen, Anna Teumer, Alexander Meta-analyses identify DNA methylation associated with kidney function and damage |
| title | Meta-analyses identify DNA methylation associated with kidney function and damage |
| title_full | Meta-analyses identify DNA methylation associated with kidney function and damage |
| title_fullStr | Meta-analyses identify DNA methylation associated with kidney function and damage |
| title_full_unstemmed | Meta-analyses identify DNA methylation associated with kidney function and damage |
| title_short | Meta-analyses identify DNA methylation associated with kidney function and damage |
| title_sort | meta-analyses identify dna methylation associated with kidney function and damage |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8660832/ https://www.ncbi.nlm.nih.gov/pubmed/34887417 http://dx.doi.org/10.1038/s41467-021-27234-3 |
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