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Estimation of COVID-19 recovery and decease periods in Canada using delay model

We derive a novel model escorted by large scale compartments, based on a set of coupled delay differential equations with extensive delays, in order to estimate the incubation, recovery and decease periods of COVID-19, and more generally any infectious disease. This is possible thanks to some optimi...

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Autores principales: Paul, Subhendu, Lorin, Emmanuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8660886/
https://www.ncbi.nlm.nih.gov/pubmed/34887456
http://dx.doi.org/10.1038/s41598-021-02982-w
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author Paul, Subhendu
Lorin, Emmanuel
author_facet Paul, Subhendu
Lorin, Emmanuel
author_sort Paul, Subhendu
collection PubMed
description We derive a novel model escorted by large scale compartments, based on a set of coupled delay differential equations with extensive delays, in order to estimate the incubation, recovery and decease periods of COVID-19, and more generally any infectious disease. This is possible thanks to some optimization algorithms applied to publicly available database of confirmed corona cases, recovered cases and death toll. In this purpose, we separate (1) the total cases into 14 groups corresponding to 14 incubation periods, (2) the recovered cases into 406 groups corresponding to a combination of incubation and recovery periods, and (3) the death toll into 406 groups corresponding to a combination of incubation and decease periods. In this paper, we focus on recovery and decease periods and their correlation with the incubation period. The estimated mean recovery period we obtain is 22.14 days (95% Confidence Interval (CI) 22.00–22.27), and the 90th percentile is 28.91 days (95% CI 28.71–29.13), which is in agreement with statistical supported studies. The bimodal gamma distribution reveals that there are two groups of recovered individuals with a short recovery period, mean 21.02 days (95% CI 20.92–21.12), and a long recovery period, mean 38.88 days (95% CI 38.61–39.15). Our study shows that the characteristic of the decease period and the recovery period are alike. From the bivariate analysis, we observe a high probability domain for recovered individuals with respect to incubation and recovery periods. A similar domain is obtained for deaths analyzing bivariate distribution of incubation and decease periods.
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spelling pubmed-86608862021-12-13 Estimation of COVID-19 recovery and decease periods in Canada using delay model Paul, Subhendu Lorin, Emmanuel Sci Rep Article We derive a novel model escorted by large scale compartments, based on a set of coupled delay differential equations with extensive delays, in order to estimate the incubation, recovery and decease periods of COVID-19, and more generally any infectious disease. This is possible thanks to some optimization algorithms applied to publicly available database of confirmed corona cases, recovered cases and death toll. In this purpose, we separate (1) the total cases into 14 groups corresponding to 14 incubation periods, (2) the recovered cases into 406 groups corresponding to a combination of incubation and recovery periods, and (3) the death toll into 406 groups corresponding to a combination of incubation and decease periods. In this paper, we focus on recovery and decease periods and their correlation with the incubation period. The estimated mean recovery period we obtain is 22.14 days (95% Confidence Interval (CI) 22.00–22.27), and the 90th percentile is 28.91 days (95% CI 28.71–29.13), which is in agreement with statistical supported studies. The bimodal gamma distribution reveals that there are two groups of recovered individuals with a short recovery period, mean 21.02 days (95% CI 20.92–21.12), and a long recovery period, mean 38.88 days (95% CI 38.61–39.15). Our study shows that the characteristic of the decease period and the recovery period are alike. From the bivariate analysis, we observe a high probability domain for recovered individuals with respect to incubation and recovery periods. A similar domain is obtained for deaths analyzing bivariate distribution of incubation and decease periods. Nature Publishing Group UK 2021-12-09 /pmc/articles/PMC8660886/ /pubmed/34887456 http://dx.doi.org/10.1038/s41598-021-02982-w Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Paul, Subhendu
Lorin, Emmanuel
Estimation of COVID-19 recovery and decease periods in Canada using delay model
title Estimation of COVID-19 recovery and decease periods in Canada using delay model
title_full Estimation of COVID-19 recovery and decease periods in Canada using delay model
title_fullStr Estimation of COVID-19 recovery and decease periods in Canada using delay model
title_full_unstemmed Estimation of COVID-19 recovery and decease periods in Canada using delay model
title_short Estimation of COVID-19 recovery and decease periods in Canada using delay model
title_sort estimation of covid-19 recovery and decease periods in canada using delay model
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8660886/
https://www.ncbi.nlm.nih.gov/pubmed/34887456
http://dx.doi.org/10.1038/s41598-021-02982-w
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