The concerted change in the distribution of cell cycle phases and zone composition in germinal centers is regulated by IL-21

Humoral immune responses require germinal centres (GC) for antibody affinity maturation. Within GC, B cell proliferation and mutation are segregated from affinity-based positive selection in the dark zone (DZ) and light zone (LZ) substructures, respectively. While IL-21 is known to be important in a...

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Detalles Bibliográficos
Autores principales: Zotos, Dimitra, Quast, Isaak, Li-Wai-Suen, Connie S. N., McKenzie, Craig I., Robinson, Marcus J., Kan, Andrey, Smyth, Gordon K., Hodgkin, Philip D., Tarlinton, David M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8660905/
https://www.ncbi.nlm.nih.gov/pubmed/34887406
http://dx.doi.org/10.1038/s41467-021-27477-0

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