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Screening of unruptured intracranial aneurysms in 50 to 60-year-old female smokers: a pilot study

The prevalence of unruptured intracranial aneurysms (UIAs) is around 2–3% in the general population. We hypothesized that the prevalence of small UIAs is higher among 50 to 60-year-old female smokers, since the incidence of aneurysmal subarachnoid hemorrhage (aSAH) is exceptionally high in 60 to 70-...

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Autores principales: Huhtakangas, Justiina, Numminen, Jussi, Pekkola, Johanna, Niemelä, Mika, Korja, Miikka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8660906/
https://www.ncbi.nlm.nih.gov/pubmed/34887429
http://dx.doi.org/10.1038/s41598-021-02963-z
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author Huhtakangas, Justiina
Numminen, Jussi
Pekkola, Johanna
Niemelä, Mika
Korja, Miikka
author_facet Huhtakangas, Justiina
Numminen, Jussi
Pekkola, Johanna
Niemelä, Mika
Korja, Miikka
author_sort Huhtakangas, Justiina
collection PubMed
description The prevalence of unruptured intracranial aneurysms (UIAs) is around 2–3% in the general population. We hypothesized that the prevalence of small UIAs is higher among 50 to 60-year-old female smokers, since the incidence of aneurysmal subarachnoid hemorrhage (aSAH) is exceptionally high in 60 to 70-year-old female smokers. Ethics approval for this pilot study of 50 women was obtained from the hospital ethics committee. In order to minimize recruitment bias, preliminary invitation letters were sent to 50 to 60-year-old women who were known to be active smokers. Those interested in participating were further informed about the study rationale and protocol. Following written consent, participants filled a detailed questionnaire and underwent computed tomography angiography (CTA) analysis. All abnormalities were recorded. Of the 158 preliminary invitation letters, 70 potential participants initially replied. Of these, 50 returned questionnaires and written consents, 43 of which underwent CTA analysis. Most (39; 91%) were postmenopausal, and 9 (21%) were hypertensive. Two reported a family history (≥ 1 first-degree members) of intracranial aneurysms. UIAs (maximum sizes of 2, 2, 3, 3 and 7 mm) were found in five (12%) female smokers. One woman was operated on, and the remaining four were treated with non-invasive preventive actions (smoking cessation and follow-ups). Small UIAs, which may be best suited for non-invasive preventive actions, may be relatively common in 50 to 60-year-old female smokers. Whether this kind of targeted screening leads to improved health in female smokers requires further investigation.
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spelling pubmed-86609062021-12-13 Screening of unruptured intracranial aneurysms in 50 to 60-year-old female smokers: a pilot study Huhtakangas, Justiina Numminen, Jussi Pekkola, Johanna Niemelä, Mika Korja, Miikka Sci Rep Article The prevalence of unruptured intracranial aneurysms (UIAs) is around 2–3% in the general population. We hypothesized that the prevalence of small UIAs is higher among 50 to 60-year-old female smokers, since the incidence of aneurysmal subarachnoid hemorrhage (aSAH) is exceptionally high in 60 to 70-year-old female smokers. Ethics approval for this pilot study of 50 women was obtained from the hospital ethics committee. In order to minimize recruitment bias, preliminary invitation letters were sent to 50 to 60-year-old women who were known to be active smokers. Those interested in participating were further informed about the study rationale and protocol. Following written consent, participants filled a detailed questionnaire and underwent computed tomography angiography (CTA) analysis. All abnormalities were recorded. Of the 158 preliminary invitation letters, 70 potential participants initially replied. Of these, 50 returned questionnaires and written consents, 43 of which underwent CTA analysis. Most (39; 91%) were postmenopausal, and 9 (21%) were hypertensive. Two reported a family history (≥ 1 first-degree members) of intracranial aneurysms. UIAs (maximum sizes of 2, 2, 3, 3 and 7 mm) were found in five (12%) female smokers. One woman was operated on, and the remaining four were treated with non-invasive preventive actions (smoking cessation and follow-ups). Small UIAs, which may be best suited for non-invasive preventive actions, may be relatively common in 50 to 60-year-old female smokers. Whether this kind of targeted screening leads to improved health in female smokers requires further investigation. Nature Publishing Group UK 2021-12-09 /pmc/articles/PMC8660906/ /pubmed/34887429 http://dx.doi.org/10.1038/s41598-021-02963-z Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Huhtakangas, Justiina
Numminen, Jussi
Pekkola, Johanna
Niemelä, Mika
Korja, Miikka
Screening of unruptured intracranial aneurysms in 50 to 60-year-old female smokers: a pilot study
title Screening of unruptured intracranial aneurysms in 50 to 60-year-old female smokers: a pilot study
title_full Screening of unruptured intracranial aneurysms in 50 to 60-year-old female smokers: a pilot study
title_fullStr Screening of unruptured intracranial aneurysms in 50 to 60-year-old female smokers: a pilot study
title_full_unstemmed Screening of unruptured intracranial aneurysms in 50 to 60-year-old female smokers: a pilot study
title_short Screening of unruptured intracranial aneurysms in 50 to 60-year-old female smokers: a pilot study
title_sort screening of unruptured intracranial aneurysms in 50 to 60-year-old female smokers: a pilot study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8660906/
https://www.ncbi.nlm.nih.gov/pubmed/34887429
http://dx.doi.org/10.1038/s41598-021-02963-z
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