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Sex Differences in Fecal Microbiota Correlation With Physiological and Biochemical Indices Associated With End-Stage Renal Disease Caused by Immunoglobulin a Nephropathy or Diabetes

This study investigated the sex-specific differences in the correlation between intestinal microbiota and end-stage renal disease. Here, we compared the differences in the gut microbiota of male and female healthy controls (HC) and patients with end-stage renal disease (ESRD) caused by immunoglobuli...

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Autores principales: Zhang, Peng, Fang, Jiali, Li, Guanghui, Zhang, Lei, Lai, Xingqiang, Xu, Lu, Liu, Luhao, Xiong, Yunyi, Li, Li, Zhang, Tao, Wan, Jiao, Xu, Hailin, Chen, Rongxin, Zhang, Weiting, Ma, Junjie, Chen, Zheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8661007/
https://www.ncbi.nlm.nih.gov/pubmed/34899638
http://dx.doi.org/10.3389/fmicb.2021.752393
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author Zhang, Peng
Fang, Jiali
Li, Guanghui
Zhang, Lei
Lai, Xingqiang
Xu, Lu
Liu, Luhao
Xiong, Yunyi
Li, Li
Zhang, Tao
Wan, Jiao
Xu, Hailin
Chen, Rongxin
Zhang, Weiting
Ma, Junjie
Chen, Zheng
author_facet Zhang, Peng
Fang, Jiali
Li, Guanghui
Zhang, Lei
Lai, Xingqiang
Xu, Lu
Liu, Luhao
Xiong, Yunyi
Li, Li
Zhang, Tao
Wan, Jiao
Xu, Hailin
Chen, Rongxin
Zhang, Weiting
Ma, Junjie
Chen, Zheng
author_sort Zhang, Peng
collection PubMed
description This study investigated the sex-specific differences in the correlation between intestinal microbiota and end-stage renal disease. Here, we compared the differences in the gut microbiota of male and female healthy controls (HC) and patients with end-stage renal disease (ESRD) caused by immunoglobulin A (IgA) nephropathy (ESRD-IgAN) or type-2 diabetes mellitus (ESRD-T2DM) using high-throughput sequencing of the 16S rRNA gene. We also analyzed the correlation between gut microbiota and clinical immune indicators. We assigned 8, 10, 5, 7, 11, and 20 volunteers to female HC, ESRD-IgAN, and ESRD-T2DM, and male HC, ESRD-IgAN, and ESRD-T2DM, respectively. The results showed sex-specific differences in both physiological and biochemical indices and intestinal microbiota composition, as well as the correlation between them. The correlations between physiological and biochemical indices in men were significantly lower than those in women, especially for indices related to immunity, blood glucose, and cardiac color sonography. Urine output, lymphocyte ratio, serum albumin, blood calcium, dialysis status, serum urea nitrogen, urine protein, and diabetes significantly correlated with male fecal microbiota composition, whereas only creatinine and 2-h post-prandial blood glucose significantly correlated with female fecal microbiota composition. The top 50 dominant operational taxonomic units showed a stronger correlation with physiological and biochemical indices in samples obtained from females than from males. These differences highlight sex-specific differences in the effectiveness of ESRD prevention and treatments via regulating intestinal microbiota.
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spelling pubmed-86610072021-12-11 Sex Differences in Fecal Microbiota Correlation With Physiological and Biochemical Indices Associated With End-Stage Renal Disease Caused by Immunoglobulin a Nephropathy or Diabetes Zhang, Peng Fang, Jiali Li, Guanghui Zhang, Lei Lai, Xingqiang Xu, Lu Liu, Luhao Xiong, Yunyi Li, Li Zhang, Tao Wan, Jiao Xu, Hailin Chen, Rongxin Zhang, Weiting Ma, Junjie Chen, Zheng Front Microbiol Microbiology This study investigated the sex-specific differences in the correlation between intestinal microbiota and end-stage renal disease. Here, we compared the differences in the gut microbiota of male and female healthy controls (HC) and patients with end-stage renal disease (ESRD) caused by immunoglobulin A (IgA) nephropathy (ESRD-IgAN) or type-2 diabetes mellitus (ESRD-T2DM) using high-throughput sequencing of the 16S rRNA gene. We also analyzed the correlation between gut microbiota and clinical immune indicators. We assigned 8, 10, 5, 7, 11, and 20 volunteers to female HC, ESRD-IgAN, and ESRD-T2DM, and male HC, ESRD-IgAN, and ESRD-T2DM, respectively. The results showed sex-specific differences in both physiological and biochemical indices and intestinal microbiota composition, as well as the correlation between them. The correlations between physiological and biochemical indices in men were significantly lower than those in women, especially for indices related to immunity, blood glucose, and cardiac color sonography. Urine output, lymphocyte ratio, serum albumin, blood calcium, dialysis status, serum urea nitrogen, urine protein, and diabetes significantly correlated with male fecal microbiota composition, whereas only creatinine and 2-h post-prandial blood glucose significantly correlated with female fecal microbiota composition. The top 50 dominant operational taxonomic units showed a stronger correlation with physiological and biochemical indices in samples obtained from females than from males. These differences highlight sex-specific differences in the effectiveness of ESRD prevention and treatments via regulating intestinal microbiota. Frontiers Media S.A. 2021-11-26 /pmc/articles/PMC8661007/ /pubmed/34899638 http://dx.doi.org/10.3389/fmicb.2021.752393 Text en Copyright © 2021 Zhang, Fang, Li, Zhang, Lai, Xu, Liu, Xiong, Li, Zhang, Wan, Xu, Chen, Zhang, Ma and Chen. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Zhang, Peng
Fang, Jiali
Li, Guanghui
Zhang, Lei
Lai, Xingqiang
Xu, Lu
Liu, Luhao
Xiong, Yunyi
Li, Li
Zhang, Tao
Wan, Jiao
Xu, Hailin
Chen, Rongxin
Zhang, Weiting
Ma, Junjie
Chen, Zheng
Sex Differences in Fecal Microbiota Correlation With Physiological and Biochemical Indices Associated With End-Stage Renal Disease Caused by Immunoglobulin a Nephropathy or Diabetes
title Sex Differences in Fecal Microbiota Correlation With Physiological and Biochemical Indices Associated With End-Stage Renal Disease Caused by Immunoglobulin a Nephropathy or Diabetes
title_full Sex Differences in Fecal Microbiota Correlation With Physiological and Biochemical Indices Associated With End-Stage Renal Disease Caused by Immunoglobulin a Nephropathy or Diabetes
title_fullStr Sex Differences in Fecal Microbiota Correlation With Physiological and Biochemical Indices Associated With End-Stage Renal Disease Caused by Immunoglobulin a Nephropathy or Diabetes
title_full_unstemmed Sex Differences in Fecal Microbiota Correlation With Physiological and Biochemical Indices Associated With End-Stage Renal Disease Caused by Immunoglobulin a Nephropathy or Diabetes
title_short Sex Differences in Fecal Microbiota Correlation With Physiological and Biochemical Indices Associated With End-Stage Renal Disease Caused by Immunoglobulin a Nephropathy or Diabetes
title_sort sex differences in fecal microbiota correlation with physiological and biochemical indices associated with end-stage renal disease caused by immunoglobulin a nephropathy or diabetes
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8661007/
https://www.ncbi.nlm.nih.gov/pubmed/34899638
http://dx.doi.org/10.3389/fmicb.2021.752393
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