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Mitochondrial Transfer in Cardiovascular Disease: From Mechanisms to Therapeutic Implications
Mitochondrial dysfunction has been proven to play a critical role in the pathogenesis of cardiovascular diseases. The phenomenon of intercellular mitochondrial transfer has been discovered in the cardiovascular system. Studies have shown that cell-to-cell mitochondrial transfer plays an essential ro...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8661009/ https://www.ncbi.nlm.nih.gov/pubmed/34901230 http://dx.doi.org/10.3389/fcvm.2021.771298 |
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author | Chen, Jun Zhong, Jinjie Wang, Lin-lin Chen, Ying-ying |
author_facet | Chen, Jun Zhong, Jinjie Wang, Lin-lin Chen, Ying-ying |
author_sort | Chen, Jun |
collection | PubMed |
description | Mitochondrial dysfunction has been proven to play a critical role in the pathogenesis of cardiovascular diseases. The phenomenon of intercellular mitochondrial transfer has been discovered in the cardiovascular system. Studies have shown that cell-to-cell mitochondrial transfer plays an essential role in regulating cardiovascular system development and maintaining normal tissue homeostasis under physiological conditions. In pathological conditions, damaged cells transfer dysfunctional mitochondria toward recipient cells to ask for help and take up exogenous functional mitochondria to alleviate injury. In this review, we summarized the mechanism of mitochondrial transfer in the cardiovascular system and outlined the fate and functional role of donor mitochondria. We also discussed the advantage and challenges of mitochondrial transfer strategies, including cell-based mitochondrial transplantation, extracellular vesicle-based mitochondrial transplantation, and naked mitochondrial transplantation, for the treatment of cardiovascular disorders. We hope this review will provide perspectives on mitochondrial-targeted therapeutics in cardiovascular diseases. |
format | Online Article Text |
id | pubmed-8661009 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-86610092021-12-11 Mitochondrial Transfer in Cardiovascular Disease: From Mechanisms to Therapeutic Implications Chen, Jun Zhong, Jinjie Wang, Lin-lin Chen, Ying-ying Front Cardiovasc Med Cardiovascular Medicine Mitochondrial dysfunction has been proven to play a critical role in the pathogenesis of cardiovascular diseases. The phenomenon of intercellular mitochondrial transfer has been discovered in the cardiovascular system. Studies have shown that cell-to-cell mitochondrial transfer plays an essential role in regulating cardiovascular system development and maintaining normal tissue homeostasis under physiological conditions. In pathological conditions, damaged cells transfer dysfunctional mitochondria toward recipient cells to ask for help and take up exogenous functional mitochondria to alleviate injury. In this review, we summarized the mechanism of mitochondrial transfer in the cardiovascular system and outlined the fate and functional role of donor mitochondria. We also discussed the advantage and challenges of mitochondrial transfer strategies, including cell-based mitochondrial transplantation, extracellular vesicle-based mitochondrial transplantation, and naked mitochondrial transplantation, for the treatment of cardiovascular disorders. We hope this review will provide perspectives on mitochondrial-targeted therapeutics in cardiovascular diseases. Frontiers Media S.A. 2021-11-26 /pmc/articles/PMC8661009/ /pubmed/34901230 http://dx.doi.org/10.3389/fcvm.2021.771298 Text en Copyright © 2021 Chen, Zhong, Wang and Chen. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cardiovascular Medicine Chen, Jun Zhong, Jinjie Wang, Lin-lin Chen, Ying-ying Mitochondrial Transfer in Cardiovascular Disease: From Mechanisms to Therapeutic Implications |
title | Mitochondrial Transfer in Cardiovascular Disease: From Mechanisms to Therapeutic Implications |
title_full | Mitochondrial Transfer in Cardiovascular Disease: From Mechanisms to Therapeutic Implications |
title_fullStr | Mitochondrial Transfer in Cardiovascular Disease: From Mechanisms to Therapeutic Implications |
title_full_unstemmed | Mitochondrial Transfer in Cardiovascular Disease: From Mechanisms to Therapeutic Implications |
title_short | Mitochondrial Transfer in Cardiovascular Disease: From Mechanisms to Therapeutic Implications |
title_sort | mitochondrial transfer in cardiovascular disease: from mechanisms to therapeutic implications |
topic | Cardiovascular Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8661009/ https://www.ncbi.nlm.nih.gov/pubmed/34901230 http://dx.doi.org/10.3389/fcvm.2021.771298 |
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