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Longitudinal Prevalence of Antibodies to Endemic Pathogens in Bulk Tank Milk Samples From Dairy Herds Engaged or Not in Contract Heifer Rearing

Since the abolition of EU milk production quotas in 2015, Europe's dairy industries have undergone a period of rapid expansion with possible resultant increased inter-herd transmission of endemic pathogens. The aims of this study were (1) to establish the post-2015 prevalence of antibodies to s...

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Autores principales: McCarthy, Marie-Claire, O'Grady, Luke, McAloon, Connor G., Mee, John F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8661010/
https://www.ncbi.nlm.nih.gov/pubmed/34901254
http://dx.doi.org/10.3389/fvets.2021.785128
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author McCarthy, Marie-Claire
O'Grady, Luke
McAloon, Connor G.
Mee, John F.
author_facet McCarthy, Marie-Claire
O'Grady, Luke
McAloon, Connor G.
Mee, John F.
author_sort McCarthy, Marie-Claire
collection PubMed
description Since the abolition of EU milk production quotas in 2015, Europe's dairy industries have undergone a period of rapid expansion with possible resultant increased inter-herd transmission of endemic pathogens. The aims of this study were (1) to establish the post-2015 prevalence of antibodies to selected endemic infectious diseases and (2) to determine if prevalences differed between herds where heifers were reared at home and those where heifers were sent out for contract-rearing. Three bulk tank milk (BTM) samples were collected annually between May and August of 2018–20 inclusively from 120 Irish dairy herds. Additionally, herd vaccination status was collected by questionnaire. Milk samples were tested using commercially available ELISAs for eight pathogens: bovine viral diarrhea virus (BVDV), bovine herpesvirus 1 (BoHv-1), bovine respiratory syncytial virus (BRSV), Mycoplasma bovis, Mycobacterium avium subspecies paratuberculosis (MAP), Salmonella Dublin (S. Dublin), Leptospira Hardjo (L. Hardjo), and Neospora caninum (N. caninum). The true prevalence of each pathogen was calculated using a Rogan-Gladen estimator. The true prevalences (95% CI) of BTM antibodies in unvaccinated herds across the 3 years were as follows (i) BVDV: 57, 86, and 73% (95% CI: 40.7–65.9, 74–94, and 58–85) (n = 56, 56, and 48), (ii) BoHv-1: 47, 49, and 19% (95% CI: 26.3–69.7, 25–75, and 1–56) (n = 21, 20, and 11), (iii) L. Hardjo: 34, 59, and 73% (95% CI: 12.5–63, 33–82, and 33–99) (n = 15, 21, and 10), (iv) S. Dublin 32, 57, and 11% (95% CI: 12.21–68.1, 30.2–90.1, and 0) (n = 19, 22, and 13), (v) BRSV: 100% (95% CI: 99.5–100, 100, and 100) (n = 120, 109, and 91), (vi) MAP: 0% (95% CI: 0, 0, and 0) (n = 120, 109, and 91) (vii) N. caninum 0% (95% CI: 0, 0, and 0) (n = 120, 109, and 91) and (viii) M. bovis (ELISA) 53, 0.42, and 30% (95% CI: 3.95–6.84, 0, and 21–41) (n = 120, 109, and 91). M. bovis was detected by PCR in 0, 1, and 0% of herds in 2018, 2019, and 2020, respectively. This study showed that expanding Irish dairy herds are endemically infected with several of the studied pathogens. No differences in herd prevalence of infectious agents were observed between farms with different heifer rearing strategies (contract-rearing vs. traditional rearing).
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spelling pubmed-86610102021-12-11 Longitudinal Prevalence of Antibodies to Endemic Pathogens in Bulk Tank Milk Samples From Dairy Herds Engaged or Not in Contract Heifer Rearing McCarthy, Marie-Claire O'Grady, Luke McAloon, Connor G. Mee, John F. Front Vet Sci Veterinary Science Since the abolition of EU milk production quotas in 2015, Europe's dairy industries have undergone a period of rapid expansion with possible resultant increased inter-herd transmission of endemic pathogens. The aims of this study were (1) to establish the post-2015 prevalence of antibodies to selected endemic infectious diseases and (2) to determine if prevalences differed between herds where heifers were reared at home and those where heifers were sent out for contract-rearing. Three bulk tank milk (BTM) samples were collected annually between May and August of 2018–20 inclusively from 120 Irish dairy herds. Additionally, herd vaccination status was collected by questionnaire. Milk samples were tested using commercially available ELISAs for eight pathogens: bovine viral diarrhea virus (BVDV), bovine herpesvirus 1 (BoHv-1), bovine respiratory syncytial virus (BRSV), Mycoplasma bovis, Mycobacterium avium subspecies paratuberculosis (MAP), Salmonella Dublin (S. Dublin), Leptospira Hardjo (L. Hardjo), and Neospora caninum (N. caninum). The true prevalence of each pathogen was calculated using a Rogan-Gladen estimator. The true prevalences (95% CI) of BTM antibodies in unvaccinated herds across the 3 years were as follows (i) BVDV: 57, 86, and 73% (95% CI: 40.7–65.9, 74–94, and 58–85) (n = 56, 56, and 48), (ii) BoHv-1: 47, 49, and 19% (95% CI: 26.3–69.7, 25–75, and 1–56) (n = 21, 20, and 11), (iii) L. Hardjo: 34, 59, and 73% (95% CI: 12.5–63, 33–82, and 33–99) (n = 15, 21, and 10), (iv) S. Dublin 32, 57, and 11% (95% CI: 12.21–68.1, 30.2–90.1, and 0) (n = 19, 22, and 13), (v) BRSV: 100% (95% CI: 99.5–100, 100, and 100) (n = 120, 109, and 91), (vi) MAP: 0% (95% CI: 0, 0, and 0) (n = 120, 109, and 91) (vii) N. caninum 0% (95% CI: 0, 0, and 0) (n = 120, 109, and 91) and (viii) M. bovis (ELISA) 53, 0.42, and 30% (95% CI: 3.95–6.84, 0, and 21–41) (n = 120, 109, and 91). M. bovis was detected by PCR in 0, 1, and 0% of herds in 2018, 2019, and 2020, respectively. This study showed that expanding Irish dairy herds are endemically infected with several of the studied pathogens. No differences in herd prevalence of infectious agents were observed between farms with different heifer rearing strategies (contract-rearing vs. traditional rearing). Frontiers Media S.A. 2021-11-25 /pmc/articles/PMC8661010/ /pubmed/34901254 http://dx.doi.org/10.3389/fvets.2021.785128 Text en Copyright © 2021 McCarthy, O'Grady, McAloon and Mee. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Veterinary Science
McCarthy, Marie-Claire
O'Grady, Luke
McAloon, Connor G.
Mee, John F.
Longitudinal Prevalence of Antibodies to Endemic Pathogens in Bulk Tank Milk Samples From Dairy Herds Engaged or Not in Contract Heifer Rearing
title Longitudinal Prevalence of Antibodies to Endemic Pathogens in Bulk Tank Milk Samples From Dairy Herds Engaged or Not in Contract Heifer Rearing
title_full Longitudinal Prevalence of Antibodies to Endemic Pathogens in Bulk Tank Milk Samples From Dairy Herds Engaged or Not in Contract Heifer Rearing
title_fullStr Longitudinal Prevalence of Antibodies to Endemic Pathogens in Bulk Tank Milk Samples From Dairy Herds Engaged or Not in Contract Heifer Rearing
title_full_unstemmed Longitudinal Prevalence of Antibodies to Endemic Pathogens in Bulk Tank Milk Samples From Dairy Herds Engaged or Not in Contract Heifer Rearing
title_short Longitudinal Prevalence of Antibodies to Endemic Pathogens in Bulk Tank Milk Samples From Dairy Herds Engaged or Not in Contract Heifer Rearing
title_sort longitudinal prevalence of antibodies to endemic pathogens in bulk tank milk samples from dairy herds engaged or not in contract heifer rearing
topic Veterinary Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8661010/
https://www.ncbi.nlm.nih.gov/pubmed/34901254
http://dx.doi.org/10.3389/fvets.2021.785128
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