Cargando…
Lidocaine exerts anticancer activity in bladder cancer by targeting isoprenylcysteine carboxylmethyltransferase (ICMT)
BACKGROUND: Bladder cancer is one of the most common malignant tumors among humans and has a high mortality. Clinically, lidocaine is the most commonly used local anesthetic, which can inhibit the proliferation of bladder cancer cells; however, its downstream specific molecular mechanisms are unclea...
Autores principales: | Teng, Xiaodan, Liu, Yang, Wang, Liping, Wang, Guonian |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
AME Publishing Company
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8661257/ https://www.ncbi.nlm.nih.gov/pubmed/34984187 http://dx.doi.org/10.21037/tau-21-893 |
Ejemplares similares
-
Analysis of the kinetic mechanism of recombinant human isoprenylcysteine carboxylmethyltransferase (Icmt)
por: Baron, Rudi A, et al.
Publicado: (2004) -
Suppression of isoprenylcysteine carboxylmethyltransferase compromises DNA damage repair
por: Tang, Jingyi, et al.
Publicado: (2021) -
Isoprenylcysteine Carboxylmethyltransferase-Based
Therapy for Hutchinson–Gilford Progeria Syndrome
por: Marcos-Ramiro, Beatriz, et al.
Publicado: (2021) -
Isoprenylcysteine carboxylmethyltransferase is critical for malignant transformation and tumor maintenance by all RAS isoforms
por: Lau, H Y, et al.
Publicado: (2017) -
Isoprenylcysteine carboxylmethyltransferase is required for the impact of mutant KRAS on TAZ protein level and cancer cell self-renewal
por: Chai, Tin Fan, et al.
Publicado: (2020)