Using lysis therapy to treat five critically ill COVID‐19 patients who show echocardiographic criteria of right ventricular strain

New options for treatment escalation in critically ill COVID‐19 patients are unmet need. Five critically ill patients were treated using a low‐dose protocol thrombolytic therapy in the form of intravenous alteplase infusion over 15 min (0.6 mg/kg). This therapeutic intervention yielded an immediate...

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Detalles Bibliográficos
Autores principales: Mahdy, Ahmed, Abbas, Eslam, Tarek, Rawad, Jabbour, Nawar, Al‐Foudri, Huda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Short Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8661526/
https://www.ncbi.nlm.nih.gov/pubmed/34909767
http://dx.doi.org/10.1002/jha2.307
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author Mahdy, Ahmed
Abbas, Eslam
Tarek, Rawad
Jabbour, Nawar
Al‐Foudri, Huda
author_facet Mahdy, Ahmed
Abbas, Eslam
Tarek, Rawad
Jabbour, Nawar
Al‐Foudri, Huda
author_sort Mahdy, Ahmed
collection PubMed
description New options for treatment escalation in critically ill COVID‐19 patients are unmet need. Five critically ill patients were treated using a low‐dose protocol thrombolytic therapy in the form of intravenous alteplase infusion over 15 min (0.6 mg/kg). This therapeutic intervention yielded an immediate favorable outcome on follow up and all five patients were extubated and transferred to the ward. This report suggests that bedside echocardiography can be a beneficial tool in the urgent assessment of the right ventricle—to—pulmonary vascular coupling in mechanically ventilated COVID‐19 patients, and thrombolytic therapy may be beneficial in hemodynamically unstable patients who show echocardiographic criteria of right ventricular strain.
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spelling pubmed-86615262021-12-10 Using lysis therapy to treat five critically ill COVID‐19 patients who show echocardiographic criteria of right ventricular strain Mahdy, Ahmed Abbas, Eslam Tarek, Rawad Jabbour, Nawar Al‐Foudri, Huda EJHaem Short Reports New options for treatment escalation in critically ill COVID‐19 patients are unmet need. Five critically ill patients were treated using a low‐dose protocol thrombolytic therapy in the form of intravenous alteplase infusion over 15 min (0.6 mg/kg). This therapeutic intervention yielded an immediate favorable outcome on follow up and all five patients were extubated and transferred to the ward. This report suggests that bedside echocardiography can be a beneficial tool in the urgent assessment of the right ventricle—to—pulmonary vascular coupling in mechanically ventilated COVID‐19 patients, and thrombolytic therapy may be beneficial in hemodynamically unstable patients who show echocardiographic criteria of right ventricular strain. John Wiley and Sons Inc. 2021-10-13 /pmc/articles/PMC8661526/ /pubmed/34909767 http://dx.doi.org/10.1002/jha2.307 Text en © 2021 The Authors. eJHaem published by British Society for Haematology and John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Reports
Mahdy, Ahmed
Abbas, Eslam
Tarek, Rawad
Jabbour, Nawar
Al‐Foudri, Huda
Using lysis therapy to treat five critically ill COVID‐19 patients who show echocardiographic criteria of right ventricular strain
title Using lysis therapy to treat five critically ill COVID‐19 patients who show echocardiographic criteria of right ventricular strain
title_full Using lysis therapy to treat five critically ill COVID‐19 patients who show echocardiographic criteria of right ventricular strain
title_fullStr Using lysis therapy to treat five critically ill COVID‐19 patients who show echocardiographic criteria of right ventricular strain
title_full_unstemmed Using lysis therapy to treat five critically ill COVID‐19 patients who show echocardiographic criteria of right ventricular strain
title_short Using lysis therapy to treat five critically ill COVID‐19 patients who show echocardiographic criteria of right ventricular strain
title_sort using lysis therapy to treat five critically ill covid‐19 patients who show echocardiographic criteria of right ventricular strain
topic Short Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8661526/
https://www.ncbi.nlm.nih.gov/pubmed/34909767
http://dx.doi.org/10.1002/jha2.307
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