Cell-Extrinsic Priming Increases Permissiveness of CD4+ T Cells to Human Immunodeficiency Virus Infection by Increasing C–C Chemokine Receptor Type 5 Co-receptor Expression and Cellular Activation Status

The chemokine receptor CCR5 is expressed on multiple cell types, including macrophages, dendritic cells, and T cells, and is the major co-receptor used during HIV transmission. Using a standard αCD3/CD28 in vitro stimulation protocol to render CD4+ T cells from PBMCs permissive to HIV infection, we...

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Detalles Bibliográficos
Autores principales: Pedersen, Jesper G., Egedal, Johanne H., Packard, Thomas A., Thavachelvam, Karthiga, Xie, Guorui, van der Sluis, Renée Marije, Greene, Warner C., Roan, Nadia R., Jakobsen, Martin R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8661899/
https://www.ncbi.nlm.nih.gov/pubmed/34899645
http://dx.doi.org/10.3389/fmicb.2021.763030

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