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Lung Ultrasound in Patients With SARS‐COV‐2 Pneumonia: Correlations With Chest Computed Tomography, Respiratory Impairment, and Inflammatory Cascade
OBJECTIVES: Lung ultrasound (LUS) might be comparable to chest computed tomography (CT) in detecting parenchymal and pleural pathology, and in monitoring interstitial lung disease. We aimed to describe LUS characteristics of patients during the hospitalization for COVID‐19 pneumonia, and to compare...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8662157/ https://www.ncbi.nlm.nih.gov/pubmed/34533859 http://dx.doi.org/10.1002/jum.15831 |
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author | Fratianni, Gerardina Malfatto, Gabriella Perger, Elisa Facchetti, Luca Pini, Laura Bosco, Miriam Cernigliaro, Franco Perego, Giovanni B. Facchini, Mario Badano, Luigi P. Parati, Gianfranco |
author_facet | Fratianni, Gerardina Malfatto, Gabriella Perger, Elisa Facchetti, Luca Pini, Laura Bosco, Miriam Cernigliaro, Franco Perego, Giovanni B. Facchini, Mario Badano, Luigi P. Parati, Gianfranco |
author_sort | Fratianni, Gerardina |
collection | PubMed |
description | OBJECTIVES: Lung ultrasound (LUS) might be comparable to chest computed tomography (CT) in detecting parenchymal and pleural pathology, and in monitoring interstitial lung disease. We aimed to describe LUS characteristics of patients during the hospitalization for COVID‐19 pneumonia, and to compare the extent of lung involvement at LUS and chest‐CT with inflammatory response and the severity of respiration impairment. METHODS: During a 2‐week period, we performed LUS and chest CT in hospitalized patients affected by COVID‐19 pneumonia. Dosages of high sensitivity C‐reactive protein (HS‐CRP), d‐dimer, and interleukin‐6 (IL‐6) were also obtained. The index of lung function (P/F ratio) was calculated from the blood gas test. LUS and CT scoring were assessed using previously validated scores. RESULTS: Twenty‐six consecutive patients (3 women) underwent LUS 34 ± 14 days from the early symptoms. Among them, 21 underwent CT on the same day of LUS. A fair association was found between LUS and CT scores (R = 0.45, P = .049), which became stronger if the B‐lines score on LUS was not considered (R = 0.57, P = .024). LUS B‐lines score correlated with IL‐6 levels (R = 0.75, P = .011), and the number of involved lung segments detected by LUS correlated with the P/F ratio (R = 0.60, P = .019) but not with HS‐CRP and d‐Dimer levels. No correlations were found between CT scores and inflammations markers or P/F. CONCLUSION: In patients with COVID‐19 pneumonia, LUS was correlated with both the extent of the inflammatory response and the P/F ratio. |
format | Online Article Text |
id | pubmed-8662157 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley & Sons, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-86621572021-12-10 Lung Ultrasound in Patients With SARS‐COV‐2 Pneumonia: Correlations With Chest Computed Tomography, Respiratory Impairment, and Inflammatory Cascade Fratianni, Gerardina Malfatto, Gabriella Perger, Elisa Facchetti, Luca Pini, Laura Bosco, Miriam Cernigliaro, Franco Perego, Giovanni B. Facchini, Mario Badano, Luigi P. Parati, Gianfranco J Ultrasound Med Original Research OBJECTIVES: Lung ultrasound (LUS) might be comparable to chest computed tomography (CT) in detecting parenchymal and pleural pathology, and in monitoring interstitial lung disease. We aimed to describe LUS characteristics of patients during the hospitalization for COVID‐19 pneumonia, and to compare the extent of lung involvement at LUS and chest‐CT with inflammatory response and the severity of respiration impairment. METHODS: During a 2‐week period, we performed LUS and chest CT in hospitalized patients affected by COVID‐19 pneumonia. Dosages of high sensitivity C‐reactive protein (HS‐CRP), d‐dimer, and interleukin‐6 (IL‐6) were also obtained. The index of lung function (P/F ratio) was calculated from the blood gas test. LUS and CT scoring were assessed using previously validated scores. RESULTS: Twenty‐six consecutive patients (3 women) underwent LUS 34 ± 14 days from the early symptoms. Among them, 21 underwent CT on the same day of LUS. A fair association was found between LUS and CT scores (R = 0.45, P = .049), which became stronger if the B‐lines score on LUS was not considered (R = 0.57, P = .024). LUS B‐lines score correlated with IL‐6 levels (R = 0.75, P = .011), and the number of involved lung segments detected by LUS correlated with the P/F ratio (R = 0.60, P = .019) but not with HS‐CRP and d‐Dimer levels. No correlations were found between CT scores and inflammations markers or P/F. CONCLUSION: In patients with COVID‐19 pneumonia, LUS was correlated with both the extent of the inflammatory response and the P/F ratio. John Wiley & Sons, Inc. 2021-09-17 2022-06 /pmc/articles/PMC8662157/ /pubmed/34533859 http://dx.doi.org/10.1002/jum.15831 Text en © 2021 The Authors. Journal of Ultrasound in Medicine published by Wiley Periodicals LLC on behalf of American Institute of Ultrasound in Medicine. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Research Fratianni, Gerardina Malfatto, Gabriella Perger, Elisa Facchetti, Luca Pini, Laura Bosco, Miriam Cernigliaro, Franco Perego, Giovanni B. Facchini, Mario Badano, Luigi P. Parati, Gianfranco Lung Ultrasound in Patients With SARS‐COV‐2 Pneumonia: Correlations With Chest Computed Tomography, Respiratory Impairment, and Inflammatory Cascade |
title | Lung Ultrasound in Patients With SARS‐COV‐2 Pneumonia: Correlations With Chest Computed Tomography, Respiratory Impairment, and Inflammatory Cascade |
title_full | Lung Ultrasound in Patients With SARS‐COV‐2 Pneumonia: Correlations With Chest Computed Tomography, Respiratory Impairment, and Inflammatory Cascade |
title_fullStr | Lung Ultrasound in Patients With SARS‐COV‐2 Pneumonia: Correlations With Chest Computed Tomography, Respiratory Impairment, and Inflammatory Cascade |
title_full_unstemmed | Lung Ultrasound in Patients With SARS‐COV‐2 Pneumonia: Correlations With Chest Computed Tomography, Respiratory Impairment, and Inflammatory Cascade |
title_short | Lung Ultrasound in Patients With SARS‐COV‐2 Pneumonia: Correlations With Chest Computed Tomography, Respiratory Impairment, and Inflammatory Cascade |
title_sort | lung ultrasound in patients with sars‐cov‐2 pneumonia: correlations with chest computed tomography, respiratory impairment, and inflammatory cascade |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8662157/ https://www.ncbi.nlm.nih.gov/pubmed/34533859 http://dx.doi.org/10.1002/jum.15831 |
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