Whole Genome Sequencing identifies reciprocal translocation hT2(I;III) breakpoints.

We used whole-genome sequencing (WGS) data from a Caenorhabditis elegans strain homozygous for the reciprocal translocation hT2(I;III) to identify its breakpoints molecularly. The translocation structure is fairly straightforward, with only minor secondary rearrangement in addition to the primary br...

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Detalles Bibliográficos
Autores principales: Flibotte, Stephane, Edgley, Mark, Au, Vinci, Moerman, Donald G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Caltech Library 2021
Materias:
New Finding
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8662349/
https://www.ncbi.nlm.nih.gov/pubmed/34909608
http://dx.doi.org/10.17912/micropub.biology.000505
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author Flibotte, Stephane
Edgley, Mark
Au, Vinci
Moerman, Donald G
author_facet Flibotte, Stephane
Edgley, Mark
Au, Vinci
Moerman, Donald G
author_sort Flibotte, Stephane
collection PubMed
description We used whole-genome sequencing (WGS) data from a Caenorhabditis elegans strain homozygous for the reciprocal translocation hT2(I;III) to identify its breakpoints molecularly. The translocation structure is fairly straightforward, with only minor secondary rearrangement in addition to the primary breakpoints. The graphical representation below depicts the two hT2 half-translocations for ease of conceptualization.
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spelling pubmed-86623492021-12-13 Whole Genome Sequencing identifies reciprocal translocation hT2(I;III) breakpoints. Flibotte, Stephane Edgley, Mark Au, Vinci Moerman, Donald G MicroPubl Biol New Finding We used whole-genome sequencing (WGS) data from a Caenorhabditis elegans strain homozygous for the reciprocal translocation hT2(I;III) to identify its breakpoints molecularly. The translocation structure is fairly straightforward, with only minor secondary rearrangement in addition to the primary breakpoints. The graphical representation below depicts the two hT2 half-translocations for ease of conceptualization. Caltech Library 2021-12-09 /pmc/articles/PMC8662349/ /pubmed/34909608 http://dx.doi.org/10.17912/micropub.biology.000505 Text en Copyright: © 2021 by the authors https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle New Finding
Flibotte, Stephane
Edgley, Mark
Au, Vinci
Moerman, Donald G
Whole Genome Sequencing identifies reciprocal translocation hT2(I;III) breakpoints.
title Whole Genome Sequencing identifies reciprocal translocation hT2(I;III) breakpoints.
title_full Whole Genome Sequencing identifies reciprocal translocation hT2(I;III) breakpoints.
title_fullStr Whole Genome Sequencing identifies reciprocal translocation hT2(I;III) breakpoints.
title_full_unstemmed Whole Genome Sequencing identifies reciprocal translocation hT2(I;III) breakpoints.
title_short Whole Genome Sequencing identifies reciprocal translocation hT2(I;III) breakpoints.
title_sort whole genome sequencing identifies reciprocal translocation ht2(i;iii) breakpoints.
topic New Finding
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8662349/
https://www.ncbi.nlm.nih.gov/pubmed/34909608
http://dx.doi.org/10.17912/micropub.biology.000505
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