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Pharmacological Activation of cGAS for Cancer Immunotherapy

When compartmentally mislocalized within cells, nucleic acids can be exceptionally immunostimulatory and can even trigger the immune-mediated elimination of cancer. Specifically, the accumulation of double-stranded DNA in the cytosol can efficiently promote antitumor immunity by activating the cGAMP...

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Detalles Bibliográficos
Autores principales:	Garland, Kyle M., Rosch, Jonah C., Carson, Carcia S., Wang-Bishop, Lihong, Hanna, Ann, Sevimli, Sema, Van Kaer, Casey, Balko, Justin M., Ascano, Manuel, Wilson, John T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8662543/ https://www.ncbi.nlm.nih.gov/pubmed/34899704 http://dx.doi.org/10.3389/fimmu.2021.753472

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