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Cohort Profile: The Socioeconomic Consequences in Adult Life After Childhood Cancer in Scandinavia (SALiCCS) Research Programme
INTRODUCTION: The growing number of survivors of childhood cancer, with many years of life ahead, demonstrates the increasing clinical and public health relevance of investigating the risks of social and socioeconomic impairment after a childhood cancer diagnosis and the life-saving treatment. To en...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8662544/ https://www.ncbi.nlm.nih.gov/pubmed/34900702 http://dx.doi.org/10.3389/fonc.2021.752948 |
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author | Erdmann, Friederike Frederiksen, Line Elmerdahl Mogensen, Hanna Pedersen, Camilla Mader, Luzius Talbäck, Mats Bautz, Andrea Hirvonen, Elli Kyrönlahti, Anniina Korhonen, Liisa Maria Hasle, Henrik Malila, Nea Madanat-Harjuoja, Laura-Maria Feychting, Maria Winther, Jeanette Falck |
author_facet | Erdmann, Friederike Frederiksen, Line Elmerdahl Mogensen, Hanna Pedersen, Camilla Mader, Luzius Talbäck, Mats Bautz, Andrea Hirvonen, Elli Kyrönlahti, Anniina Korhonen, Liisa Maria Hasle, Henrik Malila, Nea Madanat-Harjuoja, Laura-Maria Feychting, Maria Winther, Jeanette Falck |
author_sort | Erdmann, Friederike |
collection | PubMed |
description | INTRODUCTION: The growing number of survivors of childhood cancer, with many years of life ahead, demonstrates the increasing clinical and public health relevance of investigating the risks of social and socioeconomic impairment after a childhood cancer diagnosis and the life-saving treatment. To enrich understanding of the mental, social and socioeconomic difficulties that childhood cancer survivors may face during their life-course, identify particularly vulnerable survivors and overcome the limitations of previous research, we initiated the Socioeconomic Consequences in Adult Life after Childhood Cancer in Scandinavia (SALiCCS) research programme. METHODS: This Nordic cross-border research programme is a collaboration between the Danish Cancer Society, the Finnish Cancer Registry and Karolinska Institutet to investigate a broad range of mental, social and socioeconomic conditions in long-term childhood cancer survivors in Denmark, Finland and Sweden. SALiCCS is based on a registry-based matched cohort design, comprising five-year survivors of cancer diagnosed at ages 0–19 years (1971–2008 in Denmark, 1971–2009 in Finland, 1971–2011 in Sweden), age-, sex- and country-matched population comparisons and sibling comparisons who were followed over time. Outcomes of interest included mental disorders, educational achievements, employment and profession, family life and the need of social security benefits. Individual-level data linkage among various national registries provided the data for the research programme. RESULTS: The SALiCCS core population comprises 21,292 five-year survivors, 103,303 population comparisons and 29,644 siblings as a second comparison group. The most common diagnoses in survivors were central nervous system tumours, leukaemias and lymphomas. DISCUSSION: SALiCCS is the largest, most comprehensive population-based research initiative in this field, based on high-quality registry data with minimal risk of bias. The findings will be informative for evidence-based survivorship care targeting not only somatic late effects but also psychosocial impairments. |
format | Online Article Text |
id | pubmed-8662544 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-86625442021-12-11 Cohort Profile: The Socioeconomic Consequences in Adult Life After Childhood Cancer in Scandinavia (SALiCCS) Research Programme Erdmann, Friederike Frederiksen, Line Elmerdahl Mogensen, Hanna Pedersen, Camilla Mader, Luzius Talbäck, Mats Bautz, Andrea Hirvonen, Elli Kyrönlahti, Anniina Korhonen, Liisa Maria Hasle, Henrik Malila, Nea Madanat-Harjuoja, Laura-Maria Feychting, Maria Winther, Jeanette Falck Front Oncol Oncology INTRODUCTION: The growing number of survivors of childhood cancer, with many years of life ahead, demonstrates the increasing clinical and public health relevance of investigating the risks of social and socioeconomic impairment after a childhood cancer diagnosis and the life-saving treatment. To enrich understanding of the mental, social and socioeconomic difficulties that childhood cancer survivors may face during their life-course, identify particularly vulnerable survivors and overcome the limitations of previous research, we initiated the Socioeconomic Consequences in Adult Life after Childhood Cancer in Scandinavia (SALiCCS) research programme. METHODS: This Nordic cross-border research programme is a collaboration between the Danish Cancer Society, the Finnish Cancer Registry and Karolinska Institutet to investigate a broad range of mental, social and socioeconomic conditions in long-term childhood cancer survivors in Denmark, Finland and Sweden. SALiCCS is based on a registry-based matched cohort design, comprising five-year survivors of cancer diagnosed at ages 0–19 years (1971–2008 in Denmark, 1971–2009 in Finland, 1971–2011 in Sweden), age-, sex- and country-matched population comparisons and sibling comparisons who were followed over time. Outcomes of interest included mental disorders, educational achievements, employment and profession, family life and the need of social security benefits. Individual-level data linkage among various national registries provided the data for the research programme. RESULTS: The SALiCCS core population comprises 21,292 five-year survivors, 103,303 population comparisons and 29,644 siblings as a second comparison group. The most common diagnoses in survivors were central nervous system tumours, leukaemias and lymphomas. DISCUSSION: SALiCCS is the largest, most comprehensive population-based research initiative in this field, based on high-quality registry data with minimal risk of bias. The findings will be informative for evidence-based survivorship care targeting not only somatic late effects but also psychosocial impairments. Frontiers Media S.A. 2021-11-26 /pmc/articles/PMC8662544/ /pubmed/34900702 http://dx.doi.org/10.3389/fonc.2021.752948 Text en Copyright © 2021 Erdmann, Frederiksen, Mogensen, Pedersen, Mader, Talbäck, Bautz, Hirvonen, Kyrönlahti, Korhonen, Hasle, Malila, Madanat-Harjuoja, Feychting and Winther https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Erdmann, Friederike Frederiksen, Line Elmerdahl Mogensen, Hanna Pedersen, Camilla Mader, Luzius Talbäck, Mats Bautz, Andrea Hirvonen, Elli Kyrönlahti, Anniina Korhonen, Liisa Maria Hasle, Henrik Malila, Nea Madanat-Harjuoja, Laura-Maria Feychting, Maria Winther, Jeanette Falck Cohort Profile: The Socioeconomic Consequences in Adult Life After Childhood Cancer in Scandinavia (SALiCCS) Research Programme |
title | Cohort Profile: The Socioeconomic Consequences in Adult Life After Childhood Cancer in Scandinavia (SALiCCS) Research Programme |
title_full | Cohort Profile: The Socioeconomic Consequences in Adult Life After Childhood Cancer in Scandinavia (SALiCCS) Research Programme |
title_fullStr | Cohort Profile: The Socioeconomic Consequences in Adult Life After Childhood Cancer in Scandinavia (SALiCCS) Research Programme |
title_full_unstemmed | Cohort Profile: The Socioeconomic Consequences in Adult Life After Childhood Cancer in Scandinavia (SALiCCS) Research Programme |
title_short | Cohort Profile: The Socioeconomic Consequences in Adult Life After Childhood Cancer in Scandinavia (SALiCCS) Research Programme |
title_sort | cohort profile: the socioeconomic consequences in adult life after childhood cancer in scandinavia (saliccs) research programme |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8662544/ https://www.ncbi.nlm.nih.gov/pubmed/34900702 http://dx.doi.org/10.3389/fonc.2021.752948 |
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