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An Assessment of Ovarian Cancer Histotypes Across the African Diaspora
OBJECTIVE: Ovarian cancer in Black women is common in many West African countries but is relatively rare in North America. Black women have worse survival outcomes when compared to White women. Ovarian cancer histotype, diagnosis, and age at presentation are known prognostic factors for outcome. We...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8662547/ https://www.ncbi.nlm.nih.gov/pubmed/34900682 http://dx.doi.org/10.3389/fonc.2021.732443 |
| _version_ | 1784613460837924864 |
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| author | George, Sophia H. L. Omotoso, Ayodele Pinto, Andre Mustapha, Aisha Sanchez-Covarrubias, Alex P. Umar, Usman Aliyu Umar, Ali Bala Oluwasola, Timothy Abiola Okolo, Clement Abu Anthony, Umeh Uchenna Ukekwe, Francis Ikechukwu Bakari, Maisaratu A. Dahiru, Aminu M. C. Abdullahi, Habiba Ibrahim Abimiku, Bawa Ahmed Abdurrahman, Aisha Usman, Asmau Ahmed, Saad Aliyu Usman, Hadiza Abdullahi Kabir, Abba Eleje, George Uchenna Chiemeka, Michael Emeka Nzeribe, Emily Nweke, Ikechukwu Kadas, SaiduAbubakar Suleiman, Dauda E. Ekanem, Etim Uche, Umemmuo Maureen Paul, Jibrin Agwu, Uzoma Maryrose Edegbe, Felix O. Anorlu, Rose I. Banjo, Adekunbiola Ajenifuja, Kayode Olusegun Fawole, Adegboyega Adisa Kazeem, Ibrahim O. O. Magaji, Francis Silas, Olugbenga Athanasius, Boma Precious Tamunomie, Nyengidiki Kennedy Bassey, Emem Abudu, Kunle Ango, Ibrahim G. Abdullahi, Kabiru Lawal, Ishak Kabir, Suleiman Aliyu Ekanem, Victor Ezeanochie, Michael Yahaya, Usman Rahman Castillo, Melissa Nicole Bahall, Vishal Chatrani, Vikash Brambury, Ian Bowe, Saida Halliday, Darron Bruney, George Butler, Raleigh Ragin, Camille Odedina, Folakemi Chamala, Srikar Schlumbrecht, Matthew Audu, Bala |
| author_facet | George, Sophia H. L. Omotoso, Ayodele Pinto, Andre Mustapha, Aisha Sanchez-Covarrubias, Alex P. Umar, Usman Aliyu Umar, Ali Bala Oluwasola, Timothy Abiola Okolo, Clement Abu Anthony, Umeh Uchenna Ukekwe, Francis Ikechukwu Bakari, Maisaratu A. Dahiru, Aminu M. C. Abdullahi, Habiba Ibrahim Abimiku, Bawa Ahmed Abdurrahman, Aisha Usman, Asmau Ahmed, Saad Aliyu Usman, Hadiza Abdullahi Kabir, Abba Eleje, George Uchenna Chiemeka, Michael Emeka Nzeribe, Emily Nweke, Ikechukwu Kadas, SaiduAbubakar Suleiman, Dauda E. Ekanem, Etim Uche, Umemmuo Maureen Paul, Jibrin Agwu, Uzoma Maryrose Edegbe, Felix O. Anorlu, Rose I. Banjo, Adekunbiola Ajenifuja, Kayode Olusegun Fawole, Adegboyega Adisa Kazeem, Ibrahim O. O. Magaji, Francis Silas, Olugbenga Athanasius, Boma Precious Tamunomie, Nyengidiki Kennedy Bassey, Emem Abudu, Kunle Ango, Ibrahim G. Abdullahi, Kabiru Lawal, Ishak Kabir, Suleiman Aliyu Ekanem, Victor Ezeanochie, Michael Yahaya, Usman Rahman Castillo, Melissa Nicole Bahall, Vishal Chatrani, Vikash Brambury, Ian Bowe, Saida Halliday, Darron Bruney, George Butler, Raleigh Ragin, Camille Odedina, Folakemi Chamala, Srikar Schlumbrecht, Matthew Audu, Bala |
| author_sort | George, Sophia H. L. |
| collection | PubMed |
| description | OBJECTIVE: Ovarian cancer in Black women is common in many West African countries but is relatively rare in North America. Black women have worse survival outcomes when compared to White women. Ovarian cancer histotype, diagnosis, and age at presentation are known prognostic factors for outcome. We sought to conduct a preliminary comparative assessment of these factors across the African diaspora. METHODS: Patients diagnosed with ovarian cancer (all histologies) between June 2016-December 2019 in Departments of Pathology at 25 participating sites in Nigeria were identified. Comparative population-based data, inclusive of Caribbean-born Blacks (CBB) and US-born Blacks (USB), were additionally captured from the International Agency for Research on Cancer and Florida Cancer Data Systems. Histology, country of birth, and age at diagnosis data were collected and evaluated across the three subgroups: USB, CBB and Nigerians. Statistical analyses were done using chi-square and student’s t-test with significance set at p<0.05. RESULTS: Nigerians had the highest proportion of germ cell tumor (GCT, 11.5%) and sex-cord stromal (SCST, 16.2%) ovarian cancers relative to CBB and USB (p=0.001). CBB (79.4%) and USB (77.3%) women were diagnosed with a larger proportion of serous ovarian cancer than Nigerians (60.4%) (p<0.0001). Nigerians were diagnosed with epithelial ovarian cancers at the youngest age (51.7± 12.8 years) relative to USB (58.9 ± 15.0) and CBB (59.0± 13.0,p<0.001). Black women [CBB (25.2 ± 15.0), Nigerians (29.5 ± 15.1), and USB (33.9 ± 17.9)] were diagnosed with GCT younger than White women (35.4 ± 20.5, p=0.011). Black women [Nigerians (47.5 ± 15.9), USB (50.9 ± 18.3) and CBB (50.9 ± 18.3)] were also diagnosed with SCST younger than White women (55.6 ± 16.5, p<0.01). CONCLUSION: There is significant variation in age of diagnosis and distribution of ovarian cancer histotype/diagnosis across the African diaspora. The etiology of these findings requires further investigation. |
| format | Online Article Text |
| id | pubmed-8662547 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2021 |
| publisher | Frontiers Media S.A. |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-86625472021-12-11 An Assessment of Ovarian Cancer Histotypes Across the African Diaspora George, Sophia H. L. Omotoso, Ayodele Pinto, Andre Mustapha, Aisha Sanchez-Covarrubias, Alex P. Umar, Usman Aliyu Umar, Ali Bala Oluwasola, Timothy Abiola Okolo, Clement Abu Anthony, Umeh Uchenna Ukekwe, Francis Ikechukwu Bakari, Maisaratu A. Dahiru, Aminu M. C. Abdullahi, Habiba Ibrahim Abimiku, Bawa Ahmed Abdurrahman, Aisha Usman, Asmau Ahmed, Saad Aliyu Usman, Hadiza Abdullahi Kabir, Abba Eleje, George Uchenna Chiemeka, Michael Emeka Nzeribe, Emily Nweke, Ikechukwu Kadas, SaiduAbubakar Suleiman, Dauda E. Ekanem, Etim Uche, Umemmuo Maureen Paul, Jibrin Agwu, Uzoma Maryrose Edegbe, Felix O. Anorlu, Rose I. Banjo, Adekunbiola Ajenifuja, Kayode Olusegun Fawole, Adegboyega Adisa Kazeem, Ibrahim O. O. Magaji, Francis Silas, Olugbenga Athanasius, Boma Precious Tamunomie, Nyengidiki Kennedy Bassey, Emem Abudu, Kunle Ango, Ibrahim G. Abdullahi, Kabiru Lawal, Ishak Kabir, Suleiman Aliyu Ekanem, Victor Ezeanochie, Michael Yahaya, Usman Rahman Castillo, Melissa Nicole Bahall, Vishal Chatrani, Vikash Brambury, Ian Bowe, Saida Halliday, Darron Bruney, George Butler, Raleigh Ragin, Camille Odedina, Folakemi Chamala, Srikar Schlumbrecht, Matthew Audu, Bala Front Oncol Oncology OBJECTIVE: Ovarian cancer in Black women is common in many West African countries but is relatively rare in North America. Black women have worse survival outcomes when compared to White women. Ovarian cancer histotype, diagnosis, and age at presentation are known prognostic factors for outcome. We sought to conduct a preliminary comparative assessment of these factors across the African diaspora. METHODS: Patients diagnosed with ovarian cancer (all histologies) between June 2016-December 2019 in Departments of Pathology at 25 participating sites in Nigeria were identified. Comparative population-based data, inclusive of Caribbean-born Blacks (CBB) and US-born Blacks (USB), were additionally captured from the International Agency for Research on Cancer and Florida Cancer Data Systems. Histology, country of birth, and age at diagnosis data were collected and evaluated across the three subgroups: USB, CBB and Nigerians. Statistical analyses were done using chi-square and student’s t-test with significance set at p<0.05. RESULTS: Nigerians had the highest proportion of germ cell tumor (GCT, 11.5%) and sex-cord stromal (SCST, 16.2%) ovarian cancers relative to CBB and USB (p=0.001). CBB (79.4%) and USB (77.3%) women were diagnosed with a larger proportion of serous ovarian cancer than Nigerians (60.4%) (p<0.0001). Nigerians were diagnosed with epithelial ovarian cancers at the youngest age (51.7± 12.8 years) relative to USB (58.9 ± 15.0) and CBB (59.0± 13.0,p<0.001). Black women [CBB (25.2 ± 15.0), Nigerians (29.5 ± 15.1), and USB (33.9 ± 17.9)] were diagnosed with GCT younger than White women (35.4 ± 20.5, p=0.011). Black women [Nigerians (47.5 ± 15.9), USB (50.9 ± 18.3) and CBB (50.9 ± 18.3)] were also diagnosed with SCST younger than White women (55.6 ± 16.5, p<0.01). CONCLUSION: There is significant variation in age of diagnosis and distribution of ovarian cancer histotype/diagnosis across the African diaspora. The etiology of these findings requires further investigation. Frontiers Media S.A. 2021-11-26 /pmc/articles/PMC8662547/ /pubmed/34900682 http://dx.doi.org/10.3389/fonc.2021.732443 Text en Copyright © 2021 George, Omotoso, Pinto, Mustapha, Sanchez-Covarrubias, Umar, Umar, Oluwasola, Okolo, Anthony, Ukekwe, Bakari, Dahiru, Abdullahi, Abimiku, Abdurrahman, Usman, Ahmed, Usman, Kabir, Eleje, Chiemeka, Nzeribe, Nweke, Kadas, Suleiman, Ekanem, Uche, Paul, Agwu, Edegbe, Anorlu, Banjo, Ajenifuja, Fawole, Kazeem, Magaji, Silas, Athanasius, Tamunomie, Bassey, Abudu, Ango, Abdullahi, Lawal, Kabir, Ekanem, Ezeanochie, Yahaya, Castillo, Bahall, Chatrani, Brambury, Bowe, Halliday, Bruney, Butler, Ragin, Odedina, Chamala, Schlumbrecht and Audu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| spellingShingle | Oncology George, Sophia H. L. Omotoso, Ayodele Pinto, Andre Mustapha, Aisha Sanchez-Covarrubias, Alex P. Umar, Usman Aliyu Umar, Ali Bala Oluwasola, Timothy Abiola Okolo, Clement Abu Anthony, Umeh Uchenna Ukekwe, Francis Ikechukwu Bakari, Maisaratu A. Dahiru, Aminu M. C. Abdullahi, Habiba Ibrahim Abimiku, Bawa Ahmed Abdurrahman, Aisha Usman, Asmau Ahmed, Saad Aliyu Usman, Hadiza Abdullahi Kabir, Abba Eleje, George Uchenna Chiemeka, Michael Emeka Nzeribe, Emily Nweke, Ikechukwu Kadas, SaiduAbubakar Suleiman, Dauda E. Ekanem, Etim Uche, Umemmuo Maureen Paul, Jibrin Agwu, Uzoma Maryrose Edegbe, Felix O. Anorlu, Rose I. Banjo, Adekunbiola Ajenifuja, Kayode Olusegun Fawole, Adegboyega Adisa Kazeem, Ibrahim O. O. Magaji, Francis Silas, Olugbenga Athanasius, Boma Precious Tamunomie, Nyengidiki Kennedy Bassey, Emem Abudu, Kunle Ango, Ibrahim G. Abdullahi, Kabiru Lawal, Ishak Kabir, Suleiman Aliyu Ekanem, Victor Ezeanochie, Michael Yahaya, Usman Rahman Castillo, Melissa Nicole Bahall, Vishal Chatrani, Vikash Brambury, Ian Bowe, Saida Halliday, Darron Bruney, George Butler, Raleigh Ragin, Camille Odedina, Folakemi Chamala, Srikar Schlumbrecht, Matthew Audu, Bala An Assessment of Ovarian Cancer Histotypes Across the African Diaspora |
| title | An Assessment of Ovarian Cancer Histotypes Across the African Diaspora |
| title_full | An Assessment of Ovarian Cancer Histotypes Across the African Diaspora |
| title_fullStr | An Assessment of Ovarian Cancer Histotypes Across the African Diaspora |
| title_full_unstemmed | An Assessment of Ovarian Cancer Histotypes Across the African Diaspora |
| title_short | An Assessment of Ovarian Cancer Histotypes Across the African Diaspora |
| title_sort | assessment of ovarian cancer histotypes across the african diaspora |
| topic | Oncology |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8662547/ https://www.ncbi.nlm.nih.gov/pubmed/34900682 http://dx.doi.org/10.3389/fonc.2021.732443 |
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