A Positively Selected MAGEE2 LoF Allele Is Associated with Sexual Dimorphism in Human Brain Size and Shows Similar Phenotypes in Magee2 Null Mice

A nonsense allele at rs1343879 in human MAGEE2 on chromosome X has previously been reported as a strong candidate for positive selection in East Asia. This premature stop codon causing ∼80% protein truncation is characterized by a striking geographical pattern of high population differentiation: com...

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Detalles Bibliográficos
Autores principales: Szpak, Michał, Collins, Stephan C, Li, Yan, Liu, Xiao, Ayub, Qasim, Fischer, Marie-Christine, Vancollie, Valerie E, Lelliott, Christopher J, Xue, Yali, Yalcin, Binnaz, Yang, Huanming, Tyler-Smith, Chris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Discoveries
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8662591/
https://www.ncbi.nlm.nih.gov/pubmed/34464968
http://dx.doi.org/10.1093/molbev/msab243

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