Non-synaptic Cell-Autonomous Mechanisms Underlie Neuronal Hyperactivity in a Genetic Model of PIK3CA-Driven Intractable Epilepsy

Patients harboring mutations in the PI3K-AKT-MTOR pathway-encoding genes often develop a spectrum of neurodevelopmental disorders including epilepsy. A significant proportion remains unresponsive to conventional anti-seizure medications. Understanding mutation-specific pathophysiology is thus critic...

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Detalles Bibliográficos
Autores principales: Roy, Achira, Han, Victor Z., Bard, Angela M., Wehle, Devin T., Smith, Stephen E. P., Ramirez, Jan-Marino, Kalume, Franck, Millen, Kathleen J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8662737/
https://www.ncbi.nlm.nih.gov/pubmed/34899181
http://dx.doi.org/10.3389/fnmol.2021.772847

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