Neutralisation of the SARS-CoV-2 Delta variant sub-lineages AY.4.2 and B.1.617.2 with the mutation E484K by Comirnaty (BNT162b2 mRNA) vaccine-elicited sera, Denmark, 1 to 26 November 2021

Several factors may account for the recent increased spread of the SARS-CoV-2 Delta sub-lineage AY.4.2 in the United Kingdom, Romania, Poland, and Denmark. We evaluated the sensitivity of AY.4.2 to neutralisation by sera from 30 Comirnaty (BNT162b2 mRNA) vaccine recipients in Denmark in November 202...

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Autores principales: Lassaunière, Ria, Polacek, Charlotta, Fonager, Jannik, Bennedbæk, Marc, Boding, Lasse, Rasmussen, Morten, Fomsgaard, Anders
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Centre for Disease Prevention and Control (ECDC) 2021
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8662802/
https://www.ncbi.nlm.nih.gov/pubmed/34886943
http://dx.doi.org/10.2807/1560-7917.ES.2021.26.49.2101059
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author Lassaunière, Ria
Polacek, Charlotta
Fonager, Jannik
Bennedbæk, Marc
Boding, Lasse
Rasmussen, Morten
Fomsgaard, Anders
author_facet Lassaunière, Ria
Polacek, Charlotta
Fonager, Jannik
Bennedbæk, Marc
Boding, Lasse
Rasmussen, Morten
Fomsgaard, Anders
author_sort Lassaunière, Ria
collection PubMed
description Several factors may account for the recent increased spread of the SARS-CoV-2 Delta sub-lineage AY.4.2 in the United Kingdom, Romania, Poland, and Denmark. We evaluated the sensitivity of AY.4.2 to neutralisation by sera from 30 Comirnaty (BNT162b2 mRNA) vaccine recipients in Denmark in November 2021. AY.4.2 neutralisation was comparable to other circulating Delta lineages or sub-lineages. Conversely, the less prevalent B.1.617.2 with E484K showed a significant more than 4-fold reduction in neutralisation that warrants surveillance of strains with the acquired E484K mutation.
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spelling pubmed-86628022022-01-05 Neutralisation of the SARS-CoV-2 Delta variant sub-lineages AY.4.2 and B.1.617.2 with the mutation E484K by Comirnaty (BNT162b2 mRNA) vaccine-elicited sera, Denmark, 1 to 26 November 2021 Lassaunière, Ria Polacek, Charlotta Fonager, Jannik Bennedbæk, Marc Boding, Lasse Rasmussen, Morten Fomsgaard, Anders Euro Surveill Rapid Communication Several factors may account for the recent increased spread of the SARS-CoV-2 Delta sub-lineage AY.4.2 in the United Kingdom, Romania, Poland, and Denmark. We evaluated the sensitivity of AY.4.2 to neutralisation by sera from 30 Comirnaty (BNT162b2 mRNA) vaccine recipients in Denmark in November 2021. AY.4.2 neutralisation was comparable to other circulating Delta lineages or sub-lineages. Conversely, the less prevalent B.1.617.2 with E484K showed a significant more than 4-fold reduction in neutralisation that warrants surveillance of strains with the acquired E484K mutation. European Centre for Disease Prevention and Control (ECDC) 2021-12-09 /pmc/articles/PMC8662802/ /pubmed/34886943 http://dx.doi.org/10.2807/1560-7917.ES.2021.26.49.2101059 Text en This article is copyright of the authors or their affiliated institutions, 2021. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made.
spellingShingle Rapid Communication
Lassaunière, Ria
Polacek, Charlotta
Fonager, Jannik
Bennedbæk, Marc
Boding, Lasse
Rasmussen, Morten
Fomsgaard, Anders
Neutralisation of the SARS-CoV-2 Delta variant sub-lineages AY.4.2 and B.1.617.2 with the mutation E484K by Comirnaty (BNT162b2 mRNA) vaccine-elicited sera, Denmark, 1 to 26 November 2021
title Neutralisation of the SARS-CoV-2 Delta variant sub-lineages AY.4.2 and B.1.617.2 with the mutation E484K by Comirnaty (BNT162b2 mRNA) vaccine-elicited sera, Denmark, 1 to 26 November 2021
title_full Neutralisation of the SARS-CoV-2 Delta variant sub-lineages AY.4.2 and B.1.617.2 with the mutation E484K by Comirnaty (BNT162b2 mRNA) vaccine-elicited sera, Denmark, 1 to 26 November 2021
title_fullStr Neutralisation of the SARS-CoV-2 Delta variant sub-lineages AY.4.2 and B.1.617.2 with the mutation E484K by Comirnaty (BNT162b2 mRNA) vaccine-elicited sera, Denmark, 1 to 26 November 2021
title_full_unstemmed Neutralisation of the SARS-CoV-2 Delta variant sub-lineages AY.4.2 and B.1.617.2 with the mutation E484K by Comirnaty (BNT162b2 mRNA) vaccine-elicited sera, Denmark, 1 to 26 November 2021
title_short Neutralisation of the SARS-CoV-2 Delta variant sub-lineages AY.4.2 and B.1.617.2 with the mutation E484K by Comirnaty (BNT162b2 mRNA) vaccine-elicited sera, Denmark, 1 to 26 November 2021
title_sort neutralisation of the sars-cov-2 delta variant sub-lineages ay.4.2 and b.1.617.2 with the mutation e484k by comirnaty (bnt162b2 mrna) vaccine-elicited sera, denmark, 1 to 26 november 2021
topic Rapid Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8662802/
https://www.ncbi.nlm.nih.gov/pubmed/34886943
http://dx.doi.org/10.2807/1560-7917.ES.2021.26.49.2101059
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