The Transcriptional Complex Sp1/KMT2A by Up-Regulating Restrictive Element 1 Silencing Transcription Factor Accelerates Methylmercury-Induced Cell Death in Motor Neuron-Like NSC34 Cells Overexpressing SOD1-G93A

Methylmercury (MeHg) exposure has been related to amyotrophic lateral sclerosis (ALS) pathogenesis and molecular mechanisms of its neurotoxicity has been associated to an overexpression of the Restrictive Element 1 Silencing Transcription factor (REST). Herein, we evaluated the possibility that MeHg...

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Detalles Bibliográficos
Autores principales: Guida, Natascia, Sanguigno, Luca, Mascolo, Luigi, Calabrese, Lucrezia, Serani, Angelo, Molinaro, Pasquale, Lau, C. Geoffrey, Annunziato, Lucio, Formisano, Luigi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8662822/
https://www.ncbi.nlm.nih.gov/pubmed/34899171
http://dx.doi.org/10.3389/fnins.2021.771580

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