Epigenetics in neurodegenerative disorders induced by pesticides

Neurodegenerative diseases are becoming major socio-economic burdens. However, most of them still have no effective treatment. Growing evidence indicates excess exposure to pesticides are involved in the development of various forms of neurodegenerative and neurological diseases through trigger epig...

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Autores principales: Yu, Guangxia, Su, Qianqian, Chen, Yao, Wu, Lingyan, Wu, Siying, Li, Huangyuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8662853/
https://www.ncbi.nlm.nih.gov/pubmed/34893084
http://dx.doi.org/10.1186/s41021-021-00224-z
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author Yu, Guangxia
Su, Qianqian
Chen, Yao
Wu, Lingyan
Wu, Siying
Li, Huangyuan
author_facet Yu, Guangxia
Su, Qianqian
Chen, Yao
Wu, Lingyan
Wu, Siying
Li, Huangyuan
author_sort Yu, Guangxia
collection PubMed
description Neurodegenerative diseases are becoming major socio-economic burdens. However, most of them still have no effective treatment. Growing evidence indicates excess exposure to pesticides are involved in the development of various forms of neurodegenerative and neurological diseases through trigger epigenetic changes and inducing disruption of the epigenome. This review summaries studies on epigenetics alterations in nervous systems in relation to different kinds of pesticides, highlighting potential mechanism in the etiology, precision prevention and target therapy of various neurodegenerative diseases. In addition, the current gaps in research and future areas for study were also discussed.
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spelling pubmed-86628532021-12-10 Epigenetics in neurodegenerative disorders induced by pesticides Yu, Guangxia Su, Qianqian Chen, Yao Wu, Lingyan Wu, Siying Li, Huangyuan Genes Environ Review Neurodegenerative diseases are becoming major socio-economic burdens. However, most of them still have no effective treatment. Growing evidence indicates excess exposure to pesticides are involved in the development of various forms of neurodegenerative and neurological diseases through trigger epigenetic changes and inducing disruption of the epigenome. This review summaries studies on epigenetics alterations in nervous systems in relation to different kinds of pesticides, highlighting potential mechanism in the etiology, precision prevention and target therapy of various neurodegenerative diseases. In addition, the current gaps in research and future areas for study were also discussed. BioMed Central 2021-12-10 /pmc/articles/PMC8662853/ /pubmed/34893084 http://dx.doi.org/10.1186/s41021-021-00224-z Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Yu, Guangxia
Su, Qianqian
Chen, Yao
Wu, Lingyan
Wu, Siying
Li, Huangyuan
Epigenetics in neurodegenerative disorders induced by pesticides
title Epigenetics in neurodegenerative disorders induced by pesticides
title_full Epigenetics in neurodegenerative disorders induced by pesticides
title_fullStr Epigenetics in neurodegenerative disorders induced by pesticides
title_full_unstemmed Epigenetics in neurodegenerative disorders induced by pesticides
title_short Epigenetics in neurodegenerative disorders induced by pesticides
title_sort epigenetics in neurodegenerative disorders induced by pesticides
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8662853/
https://www.ncbi.nlm.nih.gov/pubmed/34893084
http://dx.doi.org/10.1186/s41021-021-00224-z
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