Functional evaluation of the P681H mutation on the proteolytic activation of the SARS-CoV-2 variant B.1.1.7 (Alpha) spike

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the agent causing the COVID-19 pandemic. SARS-CoV-2 B.1.1.7 (Alpha), a WHO variant of concern first identified in the United Kingdom in late 2020, contains several mutations including P681H in the spike S1/S2 cleavage site, which is pre...

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Detalles Bibliográficos
Autores principales: Lubinski, Bailey, Fernandes, Maureen H.V., Frazier, Laura, Tang, Tiffany, Daniel, Susan, Diel, Diego G., Jaimes, Javier A., Whittaker, Gary R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8662955/
https://www.ncbi.nlm.nih.gov/pubmed/34909610
http://dx.doi.org/10.1016/j.isci.2021.103589

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