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Zotatifin, an eIF4A-Selective Inhibitor, Blocks Tumor Growth in Receptor Tyrosine Kinase Driven Tumors

Oncoprotein expression is controlled at the level of mRNA translation and is regulated by the eukaryotic translation initiation factor 4F (eIF4F) complex. eIF4A, a component of eIF4F, catalyzes the unwinding of secondary structure in the 5’-untranslated region (5’-UTR) of mRNA to facilitate ribosome...

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Detalles Bibliográficos
Autores principales:	Gerson-Gurwitz, Adina, Young, Nathan P., Goel, Vikas K., Eam, Boreth, Stumpf, Craig R., Chen, Joan, Fish, Sarah, Barrera, Maria, Sung, Eric, Staunton, Jocelyn, Chiang, Gary G., Webster, Kevin R., Thompson, Peggy A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8663026/ https://www.ncbi.nlm.nih.gov/pubmed/34900714 http://dx.doi.org/10.3389/fonc.2021.766298

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