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SPINK1 as a plasma marker for tumor hypoxia and a therapeutic target for radiosensitization

Hypoxia is associated with tumor radioresistance; therefore, a predictive marker for tumor hypoxia and a rational target to overcome it have been sought to realize personalized radiotherapy. Here, we show that serine protease inhibitor Kazal type I (SPINK1) meets these 2 criteria. SPINK1 expression...

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Detalles Bibliográficos
Autores principales:	Suwa, Tatsuya, Kobayashi, Minoru, Shirai, Yukari, Nam, Jin-Min, Tabuchi, Yoshiaki, Takeda, Norihiko, Akamatsu, Shusuke, Ogawa, Osamu, Mizowaki, Takashi, Hammond, Ester M., Harada, Hiroshi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8663551/ https://www.ncbi.nlm.nih.gov/pubmed/34747365 http://dx.doi.org/10.1172/jci.insight.148135

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