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Quercetin Preserves Oral Cavity Health by Mitigating Inflammation and Microbial Dysbiosis

Failure to attenuate inflammation coupled with consequent microbiota changes drives the development of bone-destructive periodontitis. Quercetin, a plant-derived polyphenolic flavonoid, has been linked with health benefits in both humans and animals. Using a systematic approach, we investigated the...

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Autores principales: Mooney, Erin C., Holden, Sara E., Xia, Xia-Juan, Li, Yajie, Jiang, Min, Banson, Camille N., Zhu, Bin, Sahingur, Sinem Esra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8663773/
https://www.ncbi.nlm.nih.gov/pubmed/34899728
http://dx.doi.org/10.3389/fimmu.2021.774273
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author Mooney, Erin C.
Holden, Sara E.
Xia, Xia-Juan
Li, Yajie
Jiang, Min
Banson, Camille N.
Zhu, Bin
Sahingur, Sinem Esra
author_facet Mooney, Erin C.
Holden, Sara E.
Xia, Xia-Juan
Li, Yajie
Jiang, Min
Banson, Camille N.
Zhu, Bin
Sahingur, Sinem Esra
author_sort Mooney, Erin C.
collection PubMed
description Failure to attenuate inflammation coupled with consequent microbiota changes drives the development of bone-destructive periodontitis. Quercetin, a plant-derived polyphenolic flavonoid, has been linked with health benefits in both humans and animals. Using a systematic approach, we investigated the effect of orally delivered Quercetin on host inflammatory response, oral microbial composition and periodontal disease phenotype. In vivo, quercetin supplementation diminished gingival cytokine expression, inflammatory cell infiltrate and alveolar bone loss. Microbiome analyses revealed a healthier oral microbial composition in Quercetin-treated versus vehicle-treated group characterized by reduction in the number of pathogenic species including Enterococcus, Neisseria and Pseudomonas and increase in the number of non-pathogenic Streptococcus sp. and bacterial diversity. In vitro, Quercetin diminished inflammatory cytokine production through modulating NF-κB:A20 axis in human macrophages following challenge with oral bacteria and TLR agonists. Collectively, our findings reveal that Quercetin supplement instigates a balanced periodontal tissue homeostasis through limiting inflammation and fostering an oral cavity microenvironment conducive of symbiotic microbiota associated with health. This proof of concept study provides key evidence for translational studies to improve overall health.
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spelling pubmed-86637732021-12-11 Quercetin Preserves Oral Cavity Health by Mitigating Inflammation and Microbial Dysbiosis Mooney, Erin C. Holden, Sara E. Xia, Xia-Juan Li, Yajie Jiang, Min Banson, Camille N. Zhu, Bin Sahingur, Sinem Esra Front Immunol Immunology Failure to attenuate inflammation coupled with consequent microbiota changes drives the development of bone-destructive periodontitis. Quercetin, a plant-derived polyphenolic flavonoid, has been linked with health benefits in both humans and animals. Using a systematic approach, we investigated the effect of orally delivered Quercetin on host inflammatory response, oral microbial composition and periodontal disease phenotype. In vivo, quercetin supplementation diminished gingival cytokine expression, inflammatory cell infiltrate and alveolar bone loss. Microbiome analyses revealed a healthier oral microbial composition in Quercetin-treated versus vehicle-treated group characterized by reduction in the number of pathogenic species including Enterococcus, Neisseria and Pseudomonas and increase in the number of non-pathogenic Streptococcus sp. and bacterial diversity. In vitro, Quercetin diminished inflammatory cytokine production through modulating NF-κB:A20 axis in human macrophages following challenge with oral bacteria and TLR agonists. Collectively, our findings reveal that Quercetin supplement instigates a balanced periodontal tissue homeostasis through limiting inflammation and fostering an oral cavity microenvironment conducive of symbiotic microbiota associated with health. This proof of concept study provides key evidence for translational studies to improve overall health. Frontiers Media S.A. 2021-11-26 /pmc/articles/PMC8663773/ /pubmed/34899728 http://dx.doi.org/10.3389/fimmu.2021.774273 Text en Copyright © 2021 Mooney, Holden, Xia, Li, Jiang, Banson, Zhu and Sahingur https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Mooney, Erin C.
Holden, Sara E.
Xia, Xia-Juan
Li, Yajie
Jiang, Min
Banson, Camille N.
Zhu, Bin
Sahingur, Sinem Esra
Quercetin Preserves Oral Cavity Health by Mitigating Inflammation and Microbial Dysbiosis
title Quercetin Preserves Oral Cavity Health by Mitigating Inflammation and Microbial Dysbiosis
title_full Quercetin Preserves Oral Cavity Health by Mitigating Inflammation and Microbial Dysbiosis
title_fullStr Quercetin Preserves Oral Cavity Health by Mitigating Inflammation and Microbial Dysbiosis
title_full_unstemmed Quercetin Preserves Oral Cavity Health by Mitigating Inflammation and Microbial Dysbiosis
title_short Quercetin Preserves Oral Cavity Health by Mitigating Inflammation and Microbial Dysbiosis
title_sort quercetin preserves oral cavity health by mitigating inflammation and microbial dysbiosis
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8663773/
https://www.ncbi.nlm.nih.gov/pubmed/34899728
http://dx.doi.org/10.3389/fimmu.2021.774273
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