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The TGF-β/HDAC7 axis suppresses TCA cycle metabolism in renal cancer

Mounting evidence points to alterations in mitochondrial metabolism in renal cell carcinoma (RCC). However, the mechanisms that regulate the TCA cycle in RCC remain uncharacterized. Here, we demonstrate that loss of TCA cycle enzyme expression is retained in RCC metastatic tissues. Moreover, proteom...

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Detalles Bibliográficos
Autores principales:	Nam, Hyeyoung, Kundu, Anirban, Karki, Suman, Brinkley, Garrett J., Chandrashekar, Darshan S., Kirkman, Richard L., Liu, Juan, Liberti, Maria V., Locasale, Jason W., Mitchell, Tanecia, Varambally, Sooryanarayana, Sudarshan, Sunil
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8663777/ https://www.ncbi.nlm.nih.gov/pubmed/34609963 http://dx.doi.org/10.1172/jci.insight.148438

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