Peritransplant glucocorticoids redistribute donor T cells to the bone marrow and prevent relapse after haploidentical SCT

Patients with acute leukemia who are unable to achieve complete remission prior to allogeneic hematopoietic stem cell transplantation (SCT) have dismal outcomes, with relapse rates well in excess of 60%. Haplo-identical SCT (haplo-SCT) may allow enhanced graft-versus-leukemia (GVL) effects by virtue...

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Detalles Bibliográficos
Autores principales: Inoue, Takayuki, Koyama, Motoko, Kaida, Katsuji, Ikegame, Kazuhiro, Ensbey, Kathleen S., Samson, Luke, Takahashi, Shuichiro, Zhang, Ping, Minnie, Simone A., Maruyama, Satoshi, Ishii, Shinichi, Daimon, Takashi, Fukuda, Takahiro, Nakamae, Hirohisa, Ara, Takahide, Maruyama, Yumiko, Ishiyama, Ken, Ichinohe, Tatsuo, Atsuta, Yoshiko, Blazar, Bruce R., Furlan, Scott N., Ogawa, Hiroyasu, Hill, Geoffrey R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8663779/
https://www.ncbi.nlm.nih.gov/pubmed/34637399
http://dx.doi.org/10.1172/jci.insight.153551

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