Circulating autoreactive proteinase 3(+) B cells and tolerance checkpoints in ANCA-associated vasculitis

BACKGROUND: Little is known about the autoreactive B cells in antineutrophil cytoplasmic antibody–associated (ANCA-associated) vasculitis (AAV). We aimed to investigate tolerance checkpoints of circulating antigen-specific proteinase 3–reactive (PR3(+)) B cells. METHODS: Multicolor flow cytometry in...

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Detalles Bibliográficos
Autores principales: Berti, Alvise, Hillion, Sophie, Hummel, Amber M., Son, Young Min, Chriti, Nedra, Peikert, Tobias, Carmona, Eva M., Abdulahad, Wayel H., Heeringa, Peter, Harris, Kristina M., St. Clair, E. William, Brunetta, Paul, Fervenza, Fernando C., Langford, Carol A., Kallenberg, Cees G.M., Merkel, Peter A., Monach, Paul A., Seo, Philip, Spiera, Robert F., Stone, John H., Grandi, Guido, Sun, Jie, Pers, Jacques-Olivier, Specks, Ulrich, Cornec, Divi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2021
Materias:
Clinical Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8663783/
https://www.ncbi.nlm.nih.gov/pubmed/34618687
http://dx.doi.org/10.1172/jci.insight.150999

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