Autoreactive T cell receptors with shared germline-like α chains in type 1 diabetes

Human islet antigen reactive CD4(+) memory T cells (IAR T cells) play a key role in the pathogenesis of autoimmune type 1 diabetes (T1D). Using single-cell RNA sequencing (scRNA-Seq) to identify T cell receptors (TCRs) in IAR T cells, we have identified a class of TCRs that share TCRα chains between...

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Detalles Bibliográficos
Autores principales: Linsley, Peter S., Barahmand-pour-Whitman, Fariba, Balmas, Elisa, DeBerg, Hannah A., Flynn, Kaitlin J., Hu, Alex K., Rosasco, Mario G., Chen, Janice, O’Rourke, Colin, Serti, Elisavet, Gersuk, Vivian H., Motwani, Keshav, Seay, Howard R., Brusko, Todd M., Kwok, William W., Speake, Cate, Greenbaum, Carla J., Nepom, Gerald T., Cerosaletti, Karen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2021
Materias:
Resource and Technical Advance
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8663791/
https://www.ncbi.nlm.nih.gov/pubmed/34806648
http://dx.doi.org/10.1172/jci.insight.151349

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