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Vitamin C, From Supplement to Treatment: A Re-Emerging Adjunct for Cancer Immunotherapy?

Vitamin C (VitC), in addition to its role as a general antioxidant, has long been considered to possess direct anti-cancer activity at high doses. VitC acts through oxidant and epigenetic mechanisms, which at high doses can exert direct killing of tumor cells in vitro and delay tumor growth in vivo....

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Autores principales: Kouakanou, Léonce, Peters, Christian, Brown, Christine E., Kabelitz, Dieter, Wang, Leo D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8663797/
https://www.ncbi.nlm.nih.gov/pubmed/34899716
http://dx.doi.org/10.3389/fimmu.2021.765906
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author Kouakanou, Léonce
Peters, Christian
Brown, Christine E.
Kabelitz, Dieter
Wang, Leo D.
author_facet Kouakanou, Léonce
Peters, Christian
Brown, Christine E.
Kabelitz, Dieter
Wang, Leo D.
author_sort Kouakanou, Léonce
collection PubMed
description Vitamin C (VitC), in addition to its role as a general antioxidant, has long been considered to possess direct anti-cancer activity at high doses. VitC acts through oxidant and epigenetic mechanisms, which at high doses can exert direct killing of tumor cells in vitro and delay tumor growth in vivo. Recently, it has also been shown that pharmacologic-dose VitC can contribute to control of tumors by modulating the immune system, and studies have been done interrogating the role of physiologic-dose VitC on novel adoptive cellular therapies (ACTs). In this review, we discuss the effects of VitC on anti-tumor immune cells, as well as the mechanisms underlying those effects. We address important unanswered questions concerning both VitC and ACTs, and outline challenges and opportunities facing the use of VitC in the clinical setting as an adjunct to immune-based anti-cancer therapies.
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spelling pubmed-86637972021-12-11 Vitamin C, From Supplement to Treatment: A Re-Emerging Adjunct for Cancer Immunotherapy? Kouakanou, Léonce Peters, Christian Brown, Christine E. Kabelitz, Dieter Wang, Leo D. Front Immunol Immunology Vitamin C (VitC), in addition to its role as a general antioxidant, has long been considered to possess direct anti-cancer activity at high doses. VitC acts through oxidant and epigenetic mechanisms, which at high doses can exert direct killing of tumor cells in vitro and delay tumor growth in vivo. Recently, it has also been shown that pharmacologic-dose VitC can contribute to control of tumors by modulating the immune system, and studies have been done interrogating the role of physiologic-dose VitC on novel adoptive cellular therapies (ACTs). In this review, we discuss the effects of VitC on anti-tumor immune cells, as well as the mechanisms underlying those effects. We address important unanswered questions concerning both VitC and ACTs, and outline challenges and opportunities facing the use of VitC in the clinical setting as an adjunct to immune-based anti-cancer therapies. Frontiers Media S.A. 2021-11-12 /pmc/articles/PMC8663797/ /pubmed/34899716 http://dx.doi.org/10.3389/fimmu.2021.765906 Text en Copyright © 2021 Kouakanou, Peters, Brown, Kabelitz and Wang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Kouakanou, Léonce
Peters, Christian
Brown, Christine E.
Kabelitz, Dieter
Wang, Leo D.
Vitamin C, From Supplement to Treatment: A Re-Emerging Adjunct for Cancer Immunotherapy?
title Vitamin C, From Supplement to Treatment: A Re-Emerging Adjunct for Cancer Immunotherapy?
title_full Vitamin C, From Supplement to Treatment: A Re-Emerging Adjunct for Cancer Immunotherapy?
title_fullStr Vitamin C, From Supplement to Treatment: A Re-Emerging Adjunct for Cancer Immunotherapy?
title_full_unstemmed Vitamin C, From Supplement to Treatment: A Re-Emerging Adjunct for Cancer Immunotherapy?
title_short Vitamin C, From Supplement to Treatment: A Re-Emerging Adjunct for Cancer Immunotherapy?
title_sort vitamin c, from supplement to treatment: a re-emerging adjunct for cancer immunotherapy?
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8663797/
https://www.ncbi.nlm.nih.gov/pubmed/34899716
http://dx.doi.org/10.3389/fimmu.2021.765906
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