Replication of SARS-CoV-2 in adipose tissue determines organ and systemic lipid metabolism in hamsters and humans

Zickler et al. describe SARS-CoV-2 RNA in post-mortem samples of human adipose tissue. In the hamster model, SARS-CoV-2 propagation in adipose tissue leads to specific changes in lipid metabolism, which are reflected in lipidome patterns of hamster and human plasma.

Detalles Bibliográficos
Autores principales: Zickler, Martin, Stanelle-Bertram, Stephanie, Ehret, Sandra, Heinrich, Fabian, Lange, Philine, Schaumburg, Berfin, Kouassi, Nancy Mounogou, Beck, Sebastian, Jaeckstein, Michelle Y., Mann, Oliver, Krasemann, Susanne, Schroeder, Maria, Jarczak, Dominik, Nierhaus, Axel, Kluge, Stefan, Peschka, Manuela, Schlüter, Hartmut, Renné, Thomas, Pueschel, Klaus, Kloetgen, Andreas, Scheja, Ludger, Ondruschka, Benjamin, Heeren, Joerg, Gabriel, Guelsah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2022
Materias:
Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8663969/
https://www.ncbi.nlm.nih.gov/pubmed/34895500
http://dx.doi.org/10.1016/j.cmet.2021.12.002
Descripción
Sumario:Zickler et al. describe SARS-CoV-2 RNA in post-mortem samples of human adipose tissue. In the hamster model, SARS-CoV-2 propagation in adipose tissue leads to specific changes in lipid metabolism, which are reflected in lipidome patterns of hamster and human plasma.

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