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Replication of SARS-CoV-2 in adipose tissue determines organ and systemic lipid metabolism in hamsters and humans
Zickler et al. describe SARS-CoV-2 RNA in post-mortem samples of human adipose tissue. In the hamster model, SARS-CoV-2 propagation in adipose tissue leads to specific changes in lipid metabolism, which are reflected in lipidome patterns of hamster and human plasma.
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier Inc.
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8663969/ https://www.ncbi.nlm.nih.gov/pubmed/34895500 http://dx.doi.org/10.1016/j.cmet.2021.12.002 |
| _version_ | 1784613756989341696 |
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| author | Zickler, Martin Stanelle-Bertram, Stephanie Ehret, Sandra Heinrich, Fabian Lange, Philine Schaumburg, Berfin Kouassi, Nancy Mounogou Beck, Sebastian Jaeckstein, Michelle Y. Mann, Oliver Krasemann, Susanne Schroeder, Maria Jarczak, Dominik Nierhaus, Axel Kluge, Stefan Peschka, Manuela Schlüter, Hartmut Renné, Thomas Pueschel, Klaus Kloetgen, Andreas Scheja, Ludger Ondruschka, Benjamin Heeren, Joerg Gabriel, Guelsah |
| author_facet | Zickler, Martin Stanelle-Bertram, Stephanie Ehret, Sandra Heinrich, Fabian Lange, Philine Schaumburg, Berfin Kouassi, Nancy Mounogou Beck, Sebastian Jaeckstein, Michelle Y. Mann, Oliver Krasemann, Susanne Schroeder, Maria Jarczak, Dominik Nierhaus, Axel Kluge, Stefan Peschka, Manuela Schlüter, Hartmut Renné, Thomas Pueschel, Klaus Kloetgen, Andreas Scheja, Ludger Ondruschka, Benjamin Heeren, Joerg Gabriel, Guelsah |
| author_sort | Zickler, Martin |
| collection | PubMed |
| description | Zickler et al. describe SARS-CoV-2 RNA in post-mortem samples of human adipose tissue. In the hamster model, SARS-CoV-2 propagation in adipose tissue leads to specific changes in lipid metabolism, which are reflected in lipidome patterns of hamster and human plasma. |
| format | Online Article Text |
| id | pubmed-8663969 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2022 |
| publisher | Elsevier Inc. |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-86639692021-12-10 Replication of SARS-CoV-2 in adipose tissue determines organ and systemic lipid metabolism in hamsters and humans Zickler, Martin Stanelle-Bertram, Stephanie Ehret, Sandra Heinrich, Fabian Lange, Philine Schaumburg, Berfin Kouassi, Nancy Mounogou Beck, Sebastian Jaeckstein, Michelle Y. Mann, Oliver Krasemann, Susanne Schroeder, Maria Jarczak, Dominik Nierhaus, Axel Kluge, Stefan Peschka, Manuela Schlüter, Hartmut Renné, Thomas Pueschel, Klaus Kloetgen, Andreas Scheja, Ludger Ondruschka, Benjamin Heeren, Joerg Gabriel, Guelsah Cell Metab Letter Zickler et al. describe SARS-CoV-2 RNA in post-mortem samples of human adipose tissue. In the hamster model, SARS-CoV-2 propagation in adipose tissue leads to specific changes in lipid metabolism, which are reflected in lipidome patterns of hamster and human plasma. Elsevier Inc. 2022-01-04 2021-12-10 /pmc/articles/PMC8663969/ /pubmed/34895500 http://dx.doi.org/10.1016/j.cmet.2021.12.002 Text en © 2021 Elsevier Inc. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
| spellingShingle | Letter Zickler, Martin Stanelle-Bertram, Stephanie Ehret, Sandra Heinrich, Fabian Lange, Philine Schaumburg, Berfin Kouassi, Nancy Mounogou Beck, Sebastian Jaeckstein, Michelle Y. Mann, Oliver Krasemann, Susanne Schroeder, Maria Jarczak, Dominik Nierhaus, Axel Kluge, Stefan Peschka, Manuela Schlüter, Hartmut Renné, Thomas Pueschel, Klaus Kloetgen, Andreas Scheja, Ludger Ondruschka, Benjamin Heeren, Joerg Gabriel, Guelsah Replication of SARS-CoV-2 in adipose tissue determines organ and systemic lipid metabolism in hamsters and humans |
| title | Replication of SARS-CoV-2 in adipose tissue determines organ and systemic lipid metabolism in hamsters and humans |
| title_full | Replication of SARS-CoV-2 in adipose tissue determines organ and systemic lipid metabolism in hamsters and humans |
| title_fullStr | Replication of SARS-CoV-2 in adipose tissue determines organ and systemic lipid metabolism in hamsters and humans |
| title_full_unstemmed | Replication of SARS-CoV-2 in adipose tissue determines organ and systemic lipid metabolism in hamsters and humans |
| title_short | Replication of SARS-CoV-2 in adipose tissue determines organ and systemic lipid metabolism in hamsters and humans |
| title_sort | replication of sars-cov-2 in adipose tissue determines organ and systemic lipid metabolism in hamsters and humans |
| topic | Letter |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8663969/ https://www.ncbi.nlm.nih.gov/pubmed/34895500 http://dx.doi.org/10.1016/j.cmet.2021.12.002 |
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