Cargando…

Bilateral Whole Lung Lavage in Hereditary Pulmonary Alveolar Proteinosis in a 4-year-old Child Using Extracorporeal Membrane Oxygenation

The hereditary form of pulmonary alveolar proteinosis (PAP) is an uncommon entity. We report a case of PAP due to colony-stimulating factor 2 receptor alpha (CSF2RA) gene mutation. The standard of care includes whole lung lavage (WLL). We faced two challenges: Firstly, a severely hypoxemic patient,...

Descripción completa

Detalles Bibliográficos
Autores principales: Prabhudesai, Prahlad, Khosla, Indu, Kulkarni, Satish, Arya, Manish Kumar, Pandey, Abha, Yadav, Namrata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Jaypee Brothers Medical Publishers 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8664037/
https://www.ncbi.nlm.nih.gov/pubmed/34963730
http://dx.doi.org/10.5005/jp-journals-10071-23968
_version_ 1784613770870390784
author Prabhudesai, Prahlad
Khosla, Indu
Kulkarni, Satish
Arya, Manish Kumar
Pandey, Abha
Yadav, Namrata
author_facet Prabhudesai, Prahlad
Khosla, Indu
Kulkarni, Satish
Arya, Manish Kumar
Pandey, Abha
Yadav, Namrata
author_sort Prabhudesai, Prahlad
collection PubMed
description The hereditary form of pulmonary alveolar proteinosis (PAP) is an uncommon entity. We report a case of PAP due to colony-stimulating factor 2 receptor alpha (CSF2RA) gene mutation. The standard of care includes whole lung lavage (WLL). We faced two challenges: Firstly, a severely hypoxemic patient, and secondly, the nonavailability of appropriate size of double-lumen endotracheal tube for pediatric patients for a WLL while permitting single-lung ventilation. Hence, we performed WLL using venovenous extracorporeal membrane oxygenation (VV ECMO) with a successful outcome. The patient has been discharged and is off oxygen support since more than a year. There are only a few case reports of children having hereditary PAP treated with WLL using ECMO in Indian and Western literature. HOW TO CITE THIS ARTICLE: Prabhudesai P, Khosla I, Kulkarni S, Arya MK, Pandey A, Yadav N. Bilateral Whole Lung Lavage in Hereditary Pulmonary Alveolar Proteinosis in a 4-year-old Child Using Extra corporeal Membrane Oxygenation. Indian J Crit Care Med 2021;25(9):1069–1072.
format Online
Article
Text
id pubmed-8664037
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Jaypee Brothers Medical Publishers
record_format MEDLINE/PubMed
spelling pubmed-86640372021-12-27 Bilateral Whole Lung Lavage in Hereditary Pulmonary Alveolar Proteinosis in a 4-year-old Child Using Extracorporeal Membrane Oxygenation Prabhudesai, Prahlad Khosla, Indu Kulkarni, Satish Arya, Manish Kumar Pandey, Abha Yadav, Namrata Indian J Crit Care Med Case Report The hereditary form of pulmonary alveolar proteinosis (PAP) is an uncommon entity. We report a case of PAP due to colony-stimulating factor 2 receptor alpha (CSF2RA) gene mutation. The standard of care includes whole lung lavage (WLL). We faced two challenges: Firstly, a severely hypoxemic patient, and secondly, the nonavailability of appropriate size of double-lumen endotracheal tube for pediatric patients for a WLL while permitting single-lung ventilation. Hence, we performed WLL using venovenous extracorporeal membrane oxygenation (VV ECMO) with a successful outcome. The patient has been discharged and is off oxygen support since more than a year. There are only a few case reports of children having hereditary PAP treated with WLL using ECMO in Indian and Western literature. HOW TO CITE THIS ARTICLE: Prabhudesai P, Khosla I, Kulkarni S, Arya MK, Pandey A, Yadav N. Bilateral Whole Lung Lavage in Hereditary Pulmonary Alveolar Proteinosis in a 4-year-old Child Using Extra corporeal Membrane Oxygenation. Indian J Crit Care Med 2021;25(9):1069–1072. Jaypee Brothers Medical Publishers 2021-09 /pmc/articles/PMC8664037/ /pubmed/34963730 http://dx.doi.org/10.5005/jp-journals-10071-23968 Text en Copyright © 2021; Jaypee Brothers Medical Publishers (P) Ltd. https://creativecommons.org/licenses/by-nc/4.0/© Jaypee Brothers Medical Publishers. 2021 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted use, distribution, and non-commercial reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated.
spellingShingle Case Report
Prabhudesai, Prahlad
Khosla, Indu
Kulkarni, Satish
Arya, Manish Kumar
Pandey, Abha
Yadav, Namrata
Bilateral Whole Lung Lavage in Hereditary Pulmonary Alveolar Proteinosis in a 4-year-old Child Using Extracorporeal Membrane Oxygenation
title Bilateral Whole Lung Lavage in Hereditary Pulmonary Alveolar Proteinosis in a 4-year-old Child Using Extracorporeal Membrane Oxygenation
title_full Bilateral Whole Lung Lavage in Hereditary Pulmonary Alveolar Proteinosis in a 4-year-old Child Using Extracorporeal Membrane Oxygenation
title_fullStr Bilateral Whole Lung Lavage in Hereditary Pulmonary Alveolar Proteinosis in a 4-year-old Child Using Extracorporeal Membrane Oxygenation
title_full_unstemmed Bilateral Whole Lung Lavage in Hereditary Pulmonary Alveolar Proteinosis in a 4-year-old Child Using Extracorporeal Membrane Oxygenation
title_short Bilateral Whole Lung Lavage in Hereditary Pulmonary Alveolar Proteinosis in a 4-year-old Child Using Extracorporeal Membrane Oxygenation
title_sort bilateral whole lung lavage in hereditary pulmonary alveolar proteinosis in a 4-year-old child using extracorporeal membrane oxygenation
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8664037/
https://www.ncbi.nlm.nih.gov/pubmed/34963730
http://dx.doi.org/10.5005/jp-journals-10071-23968
work_keys_str_mv AT prabhudesaiprahlad bilateralwholelunglavageinhereditarypulmonaryalveolarproteinosisina4yearoldchildusingextracorporealmembraneoxygenation
AT khoslaindu bilateralwholelunglavageinhereditarypulmonaryalveolarproteinosisina4yearoldchildusingextracorporealmembraneoxygenation
AT kulkarnisatish bilateralwholelunglavageinhereditarypulmonaryalveolarproteinosisina4yearoldchildusingextracorporealmembraneoxygenation
AT aryamanishkumar bilateralwholelunglavageinhereditarypulmonaryalveolarproteinosisina4yearoldchildusingextracorporealmembraneoxygenation
AT pandeyabha bilateralwholelunglavageinhereditarypulmonaryalveolarproteinosisina4yearoldchildusingextracorporealmembraneoxygenation
AT yadavnamrata bilateralwholelunglavageinhereditarypulmonaryalveolarproteinosisina4yearoldchildusingextracorporealmembraneoxygenation