Cargando…
Novel oncogenes and tumor suppressor genes in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is a very deadly disease. HCC initiation and progression involve multiple genetic events, including the activation of proto-oncogenes and disruption of the function of specific tumor suppressor genes. Activation of oncogenes stimulates cell growth and survival, while l...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8664074/ https://www.ncbi.nlm.nih.gov/pubmed/34900376 http://dx.doi.org/10.1016/j.livres.2021.06.001 |
_version_ | 1784613777819303936 |
---|---|
author | Wang, Fang Breslin S J, Peter Qiu, Wei |
author_facet | Wang, Fang Breslin S J, Peter Qiu, Wei |
author_sort | Wang, Fang |
collection | PubMed |
description | Hepatocellular carcinoma (HCC) is a very deadly disease. HCC initiation and progression involve multiple genetic events, including the activation of proto-oncogenes and disruption of the function of specific tumor suppressor genes. Activation of oncogenes stimulates cell growth and survival, while loss-of-function mutations of tumor suppressor genes result in unrestrained cell growth. In this review, we summarize the new findings that identified novel proto-oncogenes and tumor suppressors in HCC over the past five years. These findings may inspire the development of novel therapeutic strategies to improve the outcome of HCC patients. |
format | Online Article Text |
id | pubmed-8664074 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
record_format | MEDLINE/PubMed |
spelling | pubmed-86640742021-12-10 Novel oncogenes and tumor suppressor genes in hepatocellular carcinoma Wang, Fang Breslin S J, Peter Qiu, Wei Liver Res Article Hepatocellular carcinoma (HCC) is a very deadly disease. HCC initiation and progression involve multiple genetic events, including the activation of proto-oncogenes and disruption of the function of specific tumor suppressor genes. Activation of oncogenes stimulates cell growth and survival, while loss-of-function mutations of tumor suppressor genes result in unrestrained cell growth. In this review, we summarize the new findings that identified novel proto-oncogenes and tumor suppressors in HCC over the past five years. These findings may inspire the development of novel therapeutic strategies to improve the outcome of HCC patients. 2021-06-23 2021-12 /pmc/articles/PMC8664074/ /pubmed/34900376 http://dx.doi.org/10.1016/j.livres.2021.06.001 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ). |
spellingShingle | Article Wang, Fang Breslin S J, Peter Qiu, Wei Novel oncogenes and tumor suppressor genes in hepatocellular carcinoma |
title | Novel oncogenes and tumor suppressor genes in hepatocellular carcinoma |
title_full | Novel oncogenes and tumor suppressor genes in hepatocellular carcinoma |
title_fullStr | Novel oncogenes and tumor suppressor genes in hepatocellular carcinoma |
title_full_unstemmed | Novel oncogenes and tumor suppressor genes in hepatocellular carcinoma |
title_short | Novel oncogenes and tumor suppressor genes in hepatocellular carcinoma |
title_sort | novel oncogenes and tumor suppressor genes in hepatocellular carcinoma |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8664074/ https://www.ncbi.nlm.nih.gov/pubmed/34900376 http://dx.doi.org/10.1016/j.livres.2021.06.001 |
work_keys_str_mv | AT wangfang noveloncogenesandtumorsuppressorgenesinhepatocellularcarcinoma AT breslinsjpeter noveloncogenesandtumorsuppressorgenesinhepatocellularcarcinoma AT qiuwei noveloncogenesandtumorsuppressorgenesinhepatocellularcarcinoma |