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Novel oncogenes and tumor suppressor genes in hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is a very deadly disease. HCC initiation and progression involve multiple genetic events, including the activation of proto-oncogenes and disruption of the function of specific tumor suppressor genes. Activation of oncogenes stimulates cell growth and survival, while l...

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Detalles Bibliográficos
Autores principales: Wang, Fang, Breslin S J, Peter, Qiu, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8664074/
https://www.ncbi.nlm.nih.gov/pubmed/34900376
http://dx.doi.org/10.1016/j.livres.2021.06.001
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author Wang, Fang
Breslin S J, Peter
Qiu, Wei
author_facet Wang, Fang
Breslin S J, Peter
Qiu, Wei
author_sort Wang, Fang
collection PubMed
description Hepatocellular carcinoma (HCC) is a very deadly disease. HCC initiation and progression involve multiple genetic events, including the activation of proto-oncogenes and disruption of the function of specific tumor suppressor genes. Activation of oncogenes stimulates cell growth and survival, while loss-of-function mutations of tumor suppressor genes result in unrestrained cell growth. In this review, we summarize the new findings that identified novel proto-oncogenes and tumor suppressors in HCC over the past five years. These findings may inspire the development of novel therapeutic strategies to improve the outcome of HCC patients.
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spelling pubmed-86640742021-12-10 Novel oncogenes and tumor suppressor genes in hepatocellular carcinoma Wang, Fang Breslin S J, Peter Qiu, Wei Liver Res Article Hepatocellular carcinoma (HCC) is a very deadly disease. HCC initiation and progression involve multiple genetic events, including the activation of proto-oncogenes and disruption of the function of specific tumor suppressor genes. Activation of oncogenes stimulates cell growth and survival, while loss-of-function mutations of tumor suppressor genes result in unrestrained cell growth. In this review, we summarize the new findings that identified novel proto-oncogenes and tumor suppressors in HCC over the past five years. These findings may inspire the development of novel therapeutic strategies to improve the outcome of HCC patients. 2021-06-23 2021-12 /pmc/articles/PMC8664074/ /pubmed/34900376 http://dx.doi.org/10.1016/j.livres.2021.06.001 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ).
spellingShingle Article
Wang, Fang
Breslin S J, Peter
Qiu, Wei
Novel oncogenes and tumor suppressor genes in hepatocellular carcinoma
title Novel oncogenes and tumor suppressor genes in hepatocellular carcinoma
title_full Novel oncogenes and tumor suppressor genes in hepatocellular carcinoma
title_fullStr Novel oncogenes and tumor suppressor genes in hepatocellular carcinoma
title_full_unstemmed Novel oncogenes and tumor suppressor genes in hepatocellular carcinoma
title_short Novel oncogenes and tumor suppressor genes in hepatocellular carcinoma
title_sort novel oncogenes and tumor suppressor genes in hepatocellular carcinoma
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8664074/
https://www.ncbi.nlm.nih.gov/pubmed/34900376
http://dx.doi.org/10.1016/j.livres.2021.06.001
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