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Platelet-Rich Plasma in Androgenetic Alopecia

The goal of these recommendations is to provide a framework to practitioners for implementing useful, evidence-based recommendations for the preparation of platelet-rich plasma (PRP) and its use in androgenetic alopecia (AGA). The Indian Association of Dermatologists, Venereologists and Leprologists...

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Autores principales: Sharma, Aseem, Chouhan, Kavish, Bhatia, Satish, Dashore, Shuken
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8664169/
https://www.ncbi.nlm.nih.gov/pubmed/34976879
http://dx.doi.org/10.4103/idoj.idoj_328_21
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author Sharma, Aseem
Chouhan, Kavish
Bhatia, Satish
Dashore, Shuken
author_facet Sharma, Aseem
Chouhan, Kavish
Bhatia, Satish
Dashore, Shuken
author_sort Sharma, Aseem
collection PubMed
description The goal of these recommendations is to provide a framework to practitioners for implementing useful, evidence-based recommendations for the preparation of platelet-rich plasma (PRP) and its use in androgenetic alopecia (AGA). The Indian Association of Dermatologists, Venereologists and Leprologists (IADVL) assigned the task of preparing these recommendations to its taskforce on PRP. A comprehensive literature search was done in the English language on the PRP across multiple databases. The grade of evidence and strength of recommendation were evaluated on the GRADE (Grading of Recommendation, Assessment, Development, and Evaluation) framework. A draft of clinical recommendations was developed on the best available evidence, which was also scrutinized and critically evaluated by the IADVL Academy of Dermatology. Based on the inputs received, the final consensus statement was prepared. A total of 30 articles (meta-analyses, prospective and retrospective studies, reviews [including chapters in books], and case series) were critically evaluated, and the evidence thus gathered was used in the preparation of these recommendations. This expert group recommends use of manual double-spin method for the preparation of PRP for AGA. Minimum three to five sessions of PRP are recommended for AGA with a gap of 1 month between the two sessions. Patients with Grade II to V Norwood Hamilton classification of AGA are the ideal subset for PRP. A total of 5 to 7 mL of PRP and 0.05 to 0.1 mL/cm(2) is the recommended dose of PRP for AGA. Activation of PRP is not required when it is used for AGA. About 1 to 1.5 million platelets/μL of platelets in PRP is the recommended platelet concentration in PRP for the treatment of AGA. I-PRF (injectable platelet-rich fibrin) has also been found to be useful in AGA, although further studies are required to establish its role. PRP can also have an adjunctive role in hair transplantation procedures.
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spelling pubmed-86641692021-12-30 Platelet-Rich Plasma in Androgenetic Alopecia Sharma, Aseem Chouhan, Kavish Bhatia, Satish Dashore, Shuken Indian Dermatol Online J Symposium Article: IADVL PRP Taskforce (IADVL Academy) The goal of these recommendations is to provide a framework to practitioners for implementing useful, evidence-based recommendations for the preparation of platelet-rich plasma (PRP) and its use in androgenetic alopecia (AGA). The Indian Association of Dermatologists, Venereologists and Leprologists (IADVL) assigned the task of preparing these recommendations to its taskforce on PRP. A comprehensive literature search was done in the English language on the PRP across multiple databases. The grade of evidence and strength of recommendation were evaluated on the GRADE (Grading of Recommendation, Assessment, Development, and Evaluation) framework. A draft of clinical recommendations was developed on the best available evidence, which was also scrutinized and critically evaluated by the IADVL Academy of Dermatology. Based on the inputs received, the final consensus statement was prepared. A total of 30 articles (meta-analyses, prospective and retrospective studies, reviews [including chapters in books], and case series) were critically evaluated, and the evidence thus gathered was used in the preparation of these recommendations. This expert group recommends use of manual double-spin method for the preparation of PRP for AGA. Minimum three to five sessions of PRP are recommended for AGA with a gap of 1 month between the two sessions. Patients with Grade II to V Norwood Hamilton classification of AGA are the ideal subset for PRP. A total of 5 to 7 mL of PRP and 0.05 to 0.1 mL/cm(2) is the recommended dose of PRP for AGA. Activation of PRP is not required when it is used for AGA. About 1 to 1.5 million platelets/μL of platelets in PRP is the recommended platelet concentration in PRP for the treatment of AGA. I-PRF (injectable platelet-rich fibrin) has also been found to be useful in AGA, although further studies are required to establish its role. PRP can also have an adjunctive role in hair transplantation procedures. Wolters Kluwer - Medknow 2021-11-25 /pmc/articles/PMC8664169/ /pubmed/34976879 http://dx.doi.org/10.4103/idoj.idoj_328_21 Text en Copyright: © 2021 Indian Dermatology Online Journal https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Symposium Article: IADVL PRP Taskforce (IADVL Academy)
Sharma, Aseem
Chouhan, Kavish
Bhatia, Satish
Dashore, Shuken
Platelet-Rich Plasma in Androgenetic Alopecia
title Platelet-Rich Plasma in Androgenetic Alopecia
title_full Platelet-Rich Plasma in Androgenetic Alopecia
title_fullStr Platelet-Rich Plasma in Androgenetic Alopecia
title_full_unstemmed Platelet-Rich Plasma in Androgenetic Alopecia
title_short Platelet-Rich Plasma in Androgenetic Alopecia
title_sort platelet-rich plasma in androgenetic alopecia
topic Symposium Article: IADVL PRP Taskforce (IADVL Academy)
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8664169/
https://www.ncbi.nlm.nih.gov/pubmed/34976879
http://dx.doi.org/10.4103/idoj.idoj_328_21
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AT chouhankavish plateletrichplasmainandrogeneticalopecia
AT bhatiasatish plateletrichplasmainandrogeneticalopecia
AT dashoreshuken plateletrichplasmainandrogeneticalopecia