Cargando…

Tomatidine reduces Chikungunya virus progeny release by controlling viral protein expression

Tomatidine, a natural steroidal alkaloid from unripe green tomatoes has been shown to exhibit many health benefits. We recently provided in vitro evidence that tomatidine reduces the infectivity of Dengue virus (DENV) and Chikungunya virus (CHIKV), two medically important arthropod-borne human infec...

Descripción completa

Detalles Bibliográficos
Autores principales:	Troost-Kind, Berit, van Hemert, Martijn J., van de Pol, Denise, van der Ende-Metselaar, Heidi, Merits, Andres, Borggrewe, Malte, Rodenhuis-Zybert, Izabela A., Smit, Jolanda M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8664216/ https://www.ncbi.nlm.nih.gov/pubmed/34762680 http://dx.doi.org/10.1371/journal.pntd.0009916

Ejemplares similares

Tomatidine, a natural steroidal alkaloid shows antiviral activity towards chikungunya virus in vitro
por: Troost, Berit, et al.
Publicado: (2020)

Mechanism and role of MCP-1 upregulation upon chikungunya virus infection in human peripheral blood mononuclear cells
por: Ruiz Silva, Mariana, et al.
Publicado: (2016)

Suppression of chikungunya virus replication and differential innate responses of human peripheral blood mononuclear cells during co-infection with dengue virus
por: Ruiz Silva, Mariana, et al.
Publicado: (2017)

Chikungunya virus requires an intact microtubule network for efficient viral genome delivery
por: Hoornweg, Tabitha E., et al.
Publicado: (2020)

Early Events in Chikungunya Virus Infection—From Virus Cell Binding to Membrane Fusion
por: van Duijl-Richter, Mareike K. S., et al.
Publicado: (2015)

Moxidectin and Ivermectin Inhibit SARS-CoV-2 Replication in Vero E6 Cells but Not in Human Primary Bronchial Epithelial Cells
por: Dinesh Kumar, Nilima, et al.
Publicado: (2022)

Resveratrol and Pterostilbene Inhibit SARS-CoV-2 Replication in Air–Liquid Interface Cultured Human Primary Bronchial Epithelial Cells
por: ter Ellen, Bram M., et al.
Publicado: (2021)

Immature Dengue Virus: A Veiled Pathogen?
por: Rodenhuis-Zybert, Izabela A., et al.
Publicado: (2010)

Antibodies against Immature Virions Are Not a Discriminating Factor for Dengue Disease Severity
por: Rodenhuis-Zybert, Izabela A., et al.
Publicado: (2015)

Antibodies against the Envelope Glycoprotein Promote Infectivity of Immature Dengue Virus Serotype 2
por: da Silva Voorham, Júlia M., et al.
Publicado: (2012)

Flavivirus Cell Entry and Membrane Fusion
por: Smit, Jolanda M., et al.
Publicado: (2011)

Applying NV center-based quantum sensing to study intracellular free radical response upon viral infections
por: Wu, Kaiqi, et al.
Publicado: (2022)

Immature Dengue Virus Is Infectious in Human Immature Dendritic Cells via Interaction with the Receptor Molecule DC-SIGN
por: Richter, Mareike K. S., et al.
Publicado: (2014)

Small-Molecule Inhibitors of Chikungunya Virus: Mechanisms of Action and Antiviral Drug Resistance
por: Kovacikova, Kristina, et al.
Publicado: (2020)

Human macrophages differentiated in the presence of vitamin D(3) restrict dengue virus infection and innate responses by downregulating mannose receptor expression
por: Arboleda Alzate, John F., et al.
Publicado: (2017)

Suramin Inhibits Chikungunya Virus Replication by Interacting with Virions and Blocking the Early Steps of Infection
por: Albulescu, Irina C., et al.
Publicado: (2020)

Tomatidine Alleviates Osteoporosis by Downregulation of p53
por: Yu, Tao, et al.
Publicado: (2020)

Bactericidal Activity of the Bacterial ATP Synthase Inhibitor Tomatidine and the Combination of Tomatidine and Aminoglycoside Against Persistent and Virulent Forms of Staphylococcus aureus
por: Langlois, Jean-Philippe, et al.
Publicado: (2020)

Regulation of innate immune responses in macrophages differentiated in the presence of vitamin D and infected with dengue virus 2
por: Castillo, Jorge Andrés, et al.
Publicado: (2021)

Antibody-independent functions of B cells during viral infections
por: Upasani, Vinit, et al.
Publicado: (2021)

Mechanisms of growth inhibition of Phytomonas serpens by the alkaloids tomatine and tomatidine
por: Medina, Jorge Mansur, et al.
Publicado: (2015)

Combination With Tomatidine Improves the Potency of Posaconazole Against Trypanosoma cruzi
por: Rocha-Hasler, Marianne, et al.
Publicado: (2021)

Tomatidine Improves Pulmonary Inflammation in Mice with Acute Lung Injury
por: Huang, Wen-Chung, et al.
Publicado: (2021)

Tomatidine provides mitophagy‐independent neuroprotection after ischemic injury
por: Wang, Yu‐ting, et al.
Publicado: (2021)

Dissecting the Cell Entry Pathway of Dengue Virus by Single-Particle Tracking in Living Cells
por: van der Schaar, Hilde M., et al.
Publicado: (2008)

Functions of Chikungunya Virus Nonstructural Proteins
por: Ahola, Tero, et al.
Publicado: (2016)

Mediators of Obesity Do Not Influence SARS-CoV-2 Infection or Activation of Primary Human Lung Microvascular Endothelial Cells In Vitro
por: ter Ellen, Bram M., et al.
Publicado: (2022)

The Steroidal Alkaloid Tomatidine and Tomatidine-Rich Tomato Leaf Extract Suppress the Human Gastric Cancer-Derived 85As2 Cells In Vitro and In Vivo via Modulation of Interferon-Stimulated Genes
por: Fujimaki, Junya, et al.
Publicado: (2022)

Concise Large-Scale Synthesis of Tomatidine, A Potent Antibiotic Natural Product
por: Normandin, Chad, et al.
Publicado: (2021)

Cooperative Chikungunya Virus Membrane Fusion and Its Substoichiometric Inhibition by CHK-152 Antibody
por: Blijleven, Jelle S., et al.
Publicado: (2022)

TLR2 axis on peripheral blood mononuclear cells regulates inflammatory responses to non-infectious immature dengue virus particles
por: Aguilar Briseño, José Alberto, et al.
Publicado: (2022)

Tomatidine suppresses inflammation in primary articular chondrocytes and attenuates cartilage degradation in osteoarthritic rats
por: Chu, Xiangyu, et al.
Publicado: (2020)

Tomatidine inhibits porcine epidemic diarrhea virus replication by targeting 3CL protease
por: Wang, Pengcheng, et al.
Publicado: (2020)

Characterization of soluble TLR2 and CD14 levels during acute dengue virus infection
por: Upasani, Vinit, et al.
Publicado: (2023)

Systems-based Discovery of Tomatidine as a Natural Small Molecule Inhibitor of Skeletal Muscle Atrophy
por: Dyle, Michael C., et al.
Publicado: (2014)

Total Phenolic, Flavonoid, Tomatine, and Tomatidine Contents and Antioxidant and Antimicrobial Activities of Extracts of Tomato Plant
por: Silva-Beltrán, Norma Patricia, et al.
Publicado: (2015)

Correction for: Tomatidine suppresses inflammation in primary articular chondrocytes and attenuates cartilage degradation in osteoarthritic rats
por: Chu, Xiangyu, et al.
Publicado: (2022)

Tomatidine-stimulated maturation of human embryonic stem cell-derived cardiomyocytes for modeling mitochondrial dysfunction
por: Kim, Ye Seul, et al.
Publicado: (2022)

Tomatidine targets ATF4-dependent signaling and induces ferroptosis to limit pancreatic cancer progression
por: Mukherjee, Debasmita, et al.
Publicado: (2023)

Characterization of Synthetic Chikungunya Viruses Based on the Consensus Sequence of Recent E1-226V Isolates
por: Scholte, Florine E. M., et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_2las35p0131er6flmg11ulp04i